High Serum Resistin Levels Predict Future Acute Kidney Injury in Kidney Transplantation Patients
1Surgery, Tzu Chi General Hospital, Hualien, Taiwan
2Nephrology, Tzu Chi General Hospital, Hualien, Taiwan
3School of Medicine, Tzu Chi University, Hualien, Taiwan.
Meeting: 2018 American Transplant Congress
Abstract number: A211
Keywords: Graft function, Kidney transplantation, Metabolic complications
Session Information
Session Name: Poster Session A: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Introduction:Resistin has a pathogenic role in the development and progression of atherosclerosis. This study was evaluated the association between serum resistin levels and future acute kidney injury events in patients with kidney transplantation (KT).
Materials and Methods: A total of 68 KT patients were enrolled in this study. The primary end point was the acute kidney injury according to KDIGO criteria.
Results: During a median 65-month follow-up, 30 acute kidney injury events occurred. Serum resistin level was positively associated with BUN, creatinine, while negatively associated with GFR. KT patients with acute kidney injury events have higher BUN, creatinine, and higher serum resistin levels, but lower GFR compared to subjects without acute kidney injury events. The Kaplan–Meier analysis showed that the cumulative incidence of the acute kidney injury events in the high resistin group (median resistin concentration of ≥ 12.72 ng/mL) was greater than that in the low resistin group
. By multivariate Cox analysis after adjusted age, gender, diabetes, hypertension showed that GFR and serum resistin levels was independently associated with acute kidney injury events in KT patients.
| Univariate | Multivariate | ||||
| Hazard Ratio (95% CI) | P value | Hazard Ratio (95% CI) | P value | ||
| Resistin, 1 ng/mL | 1.043 (1.019-1.068) | < 0.001* | 1.030 (1.001-1.060) | 0.046* | |
| Glomerular filtration rate, 1 mL/min | 0.969 (0.951-0.986) | 0.001* | 0.973 (0.954-0.991) | 0.005* | |
| Age, 1 year | 1.009 (0.972-1.048) | 0.624 | 1.008 (0.966-1.053) | 0.704 | |
| Male gender | 1.028 (0.718-1.471) | 0.881 | 1.191 (0.800-1.771) | 0.389 | |
| Diabetes mellitus | 1.181 (0.562-2.483) | 0.660 | 1.188 (0.511-2.762) | 0.689 | |
| Hypertension | 1.772 (0.860-3.650) | 0.121 | 1.319 (0.570-3.048) | 0.518 | |
Conclusion:Serum resistin level is a biomarker for future acute kidney injury events in KT patients.
CITATION INFORMATION: Lee M-.C., Hsu B-.G. High Serum Resistin Levels Predict Future Acute Kidney Injury in Kidney Transplantation Patients Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Lee M-C, Hsu B-G. High Serum Resistin Levels Predict Future Acute Kidney Injury in Kidney Transplantation Patients [abstract]. https://atcmeetingabstracts.com/abstract/high-serum-resistin-levels-predict-future-acute-kidney-injury-in-kidney-transplantation-patients/. Accessed November 26, 2024.« Back to 2018 American Transplant Congress