Vascular calcification is associated with significant morbidity and mortality in chronic kidney diseases and kidney transplantation improves mineral metabolism. However, it is not known whether vascular calcification may impact in clinical outcomes in transplanted patients. The aim of this study was to compare the clinical outcomes between transplant patients with and without vascular calcifications. In this observational, prospective study, 126 kidney transplant patients were included. Fifty-eight patients presented vascular calcifications (VC) on plain radiographic films of pelvis, hands and lumbar, assessed before and at one year after the transplantation. We observed that patients with VC presented higher plasma concentration of calcium and iPTH, at one year and two years post-transplantation, respectively. There were no differences between both groups of patients in plasma levels of alkaline phosphatase, phosphate and 25-hydroxyvitamin D. Remarkably, we observed that patients with VC showed higher levels of plasma creatinine and proteinuria at one year post-transplant. However, these differences were not statistically significant at longer time period. Patients survival at four years' post-transplant, was higher within the group of patients without VC (91.2 %) than VC group (77.6 %). However, there was no differences in graft functions between both group of patients.

Overall these results suggest that patients with VC had an early impact on mineral metabolism and kidney function that reflects with a lower patient survival at four years' post-transplant.

CITATION INFORMATION: León L., Uriona A., Hidalgo J., Condori L., Guardia O., Chuluyan E., Casadei D. Four Years Follow-Up in Kidney Transplant Patients with Vascular Calcifications Am J Transplant. 2017;17 (suppl 3).

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