Outcomes of Organ Transplantation from Donors with Cancer History

Z. Guo,¹ X. He,¹ S. Huang.¹

¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
²Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology, Sun Yat-sen University, Guangzhou, China
³Guangdong Provincial International Cooperation Base of Science and Technology, Sun Yat-sen University, Guangzhou, China.

Meeting: 2018 American Transplant Congress

Abstract number: 267

Keywords: Allocation, Graft survival, High-risk, Post-transplant malignancy

Session Information

Session Name: Concurrent Session: PTLD/Malignancies: All Topics

Session Type: Concurrent Session

Date: Monday, June 4, 2018

Session Time: 2:30pm-4:00pm

Presentation Time: 2:30pm-2:42pm

Location: Room 4C-4

Purpose: The inherent challenges of selecting an acceptable donor for each of the increasing numbers and acuity of recipients has led programs to take increased risks. The outcomes of organ transplantation using organs from DWCH remained to be clarified. We aimed to make an assessment of transplant outcomes of recipients using organs from DWCH.

Methods: Retrospective analysis of the Scientific Registry of Transplant Recipients data from January 1st, 2000 to December 31th, 2014, identified 8385 cases of transplants from DWCH. Survival analysis with risk variables adjustment were compared in recipients from donors with versus without cancer history. A Cox-proportional hazard regression model and the log-rank test were used to compare the survival, hazard level of various types of cancer.

Results: The number of DWCH was growing. Results showed that DWCH was an independent risk factor of 5-year patient survival (HR=1.089, 95% CI: 1.009-1.176, P=0.03) and graft survival (HR=1.129, 95% CI: 1.056-1.208, P<0.01) in liver transplantation and heart transplantation (patient survival: HR=1.112, 95% CI: 1.057-1.170, P<0.01; graft survival: HR=1.244, 95% CI: 1.052-1.472, P=0.01). There was no remarkable difference between two groups in kidney and lung transplantation. The adjusted cumulative probability of malignancy showed no difference in kidney, liver, heart and lung transplantation. Donors with genitourinary and gastrointestinal cancers were related to inferior outcomes in kidney transplantation. Donors with central nervous system cancer resulted in poorer survival in liver transplant recipients. Recipients from donors with hematologic malignancy and otorhinolaryngologic cancer had a poorer survival in heart transplantation.

Conclusion: Under the current donor selection criteria, recipients from DWCH had inferior outcomes in liver and heart transplantation. Specific cancer types should be evaluated before applying to distinct organ transplantation.

CITATION INFORMATION: Guo Z., He X., Huang S. Outcomes of Organ Transplantation from Donors with Cancer History Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Guo Z, He X, Huang S. Outcomes of Organ Transplantation from Donors with Cancer History [abstract]. https://atcmeetingabstracts.com/abstract/outcomes-of-organ-transplantation-from-donors-with-cancer-history/. Accessed November 23, 2024.

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