Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients.
Children's National, Washington DC
Meeting: 2017 American Transplant Congress
Abstract number: D160
Keywords: African-American, Echocardiography, Heart, Obesity
Session Information
Session Name: Poster Session D: Kidney: Pediatric
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
A prospective controlled longitudinal study was conducted to investigate determinants of carotid intima-media thickness (CIMT) and myocardial strain in children after kidney transplant (Tx).
Methods: 42 pediatric kidney Tx recipients had CIMT and strain measured pre-Tx, and 1,18, and 30 mo post-Tx. CV parameters were compared with healthy controls(n=24) by t-test. Determinants of CV function assessed by multivariate longitudinal regression.
Results: Strain of Tx was worse vs. controls (p<0.02#), with obese Tx worse than lean (p<0.05*@^). 
CIMT of AA Tx was higher vs.non-AA Tx(.49+0.007 vs .43+0.004) and AA controls (.47+0.009mm),p<0.05. Obesity and HTN were determinants of worse strain, while AA race was determinant of increased CIMT, Table 1.
| Table 1. | Mulitvariate Longitudinal GEE Regression Analysis | |||
| CIMT | Unadjusted Coefficient (95%CI) | p value | Adjusted Coefficient (95%CI) | p value |
| AA race | 0.04+0.0008 (0.03-0.06) | 0.0001 | 0.04+0.02 (0.03-0.06) | 0.0001 |
| Obesity | -0.01+0.008 (-.03-0.003) | 0.12 | -0.001+0.01 (-0.01-0.01) | 0.86 |
| HTN | 0.004+0.009 (-0.01-0.02) | 0.60 | 0.005+0.01 (-0.008-0.02) | 0.45 |
| Dyslipidemia | 0.0003+0.006 (-0.01-0.01) | 0.97 | 0.005+0.006 (-0.008-0.02) | 0.48 |
| Age | -0.001+0.001 (-.003-0.001) | 0.27 | -0.002+0.0008 (-0.004- -0.001) | 0.01 |
| Sex | 0.004+0.01 (-.01-0.03) | 0.70 | -0.001+0.008 (-0.02-0.02) | 0.97 |
| Myocardial Strain | ||||
| Obesity | 2.0+0.7 (0.6-3.3) | 0.005 | 1.7+0.7 (0.3-3.3) | 0.02 |
| HTN | 1.6+0.02 (0.2-2.9) | 0.02 | 1.3+0.6 (0.1-2.6) | 0.04 |
| Sex | 0.6+0.7 (-0.7-1.9) | 0.4 | 0.2+0.7 (-1.2-1.5) | 0.8 |
| Race | -0.3+0.6 (-1.5-0.9) | 0.6 | -0.2+0.6 (-1.5-1) | 0.7 |
| Age | 0.04+0.07(-.1-0.2) | 0.5 | 0.02+.07 (-0.1-0.2) | 0.7 |
Conclusions: AA Tx children have increased CIMT, with race as the key determinant of CIMT. All Tx children exhibit impaired myocardial strain, indicating ongoing subtle dysfunction which is negatively impacted by obesity and HTN.
CITATION INFORMATION: Sgambat K, Clauss S, Lasota M, Moudgil A. Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Sgambat K, Clauss S, Lasota M, Moudgil A. Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/carotid-intima-media-thickness-and-myocardial-strain-in-pediatric-kidney-transplant-recipients/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress