Donor Age > 50 Years and CIT Longer Than 18 Hour Are Independent Risk Factors for One Year Graft Survival in Renal Transplant Form Uncontrolled Donors After Circulatory Death (uDCD).
Nephrology Department, Hospital Universitario 12 de Octubre, Madrid, Spain
Nephrology Department, Hospital Evangelico y Hospital Militar, Montevideo, Uruguay
Meeting: 2017 American Transplant Congress
Abstract number: C29
Keywords: Donors, Kidney transplantation, non-heart-beating
Session Information
Session Name: Poster Session C: Deceased Donor Issues II: DCD, DGF, AKI, En-Bloc
Session Type: Poster Session
Date: Monday, May 1, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Introduction: Kidneys transplantations (KT) from uDCD have higher ischemia injury. It develops in higher primary non-function and delayed graft function, lower graft survival and worst renal function than ideal donors. However a optimal use of kidney from uDCD help us to reduce the otherwise, large renal transplant waiting list.
Aim: To identify donor and procurement factors of uDCD and their influence with one-year graft survival.
Material and Methods: We included all patients that received a KT form uDCD with at least one year of follow-up. We reviewed variables of uDCD and their influence in one-year death censored graft survival .
Results: We included 264 KT from uDCD. Donor characteristics were: age 44±9.7 years old, 87% (231) males, weight 80.5±11.5 kilograms, body mass index 26.8±3.2 kg/m2 and serum creatinine 1.3±0,4 mg/dl. 79.2% (209) of KT had delayed graft function. One-year graft survival was 90%. 27 grafts were lost in the first year, 67% of them (18) were non-primary function. Multivariable study is shown in the table.
| Variable | Univariate | Multivariate |
| Donor > 50 years old | 2.3 (1.1-5) P=0.02 | 2.4 (1.1-5.3) p=0.03 |
| Body mass index > 30 kg/m2 | 2.2 (0.6-8.3) p=0.22 | – |
| Cold ischemia time > 18 hours | 2.7 (1.1-6.5) p=0.02 | 2.8 (1.2-6.7) p=0.02 |
Conclusion: Kidney transplantations from uDCD have a good 1-year survival. A good choice of the donor avoiding older donors and a reduction of cold isquemia time to prevent additional ischemic damage could improve the one year graft survival in this KT from DCDD programs.
CITATION INFORMATION: Molina M, Gutierrez E, Gonzalez E, Morales E, Cabrera J, Andres A. Donor Age > 50 Years and CIT Longer Than 18 Hour Are Independent Risk Factors for One Year Graft Survival in Renal Transplant Form Uncontrolled Donors After Circulatory Death (uDCD). Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Molina M, Gutierrez E, Gonzalez E, Morales E, Cabrera J, Andres A. Donor Age > 50 Years and CIT Longer Than 18 Hour Are Independent Risk Factors for One Year Graft Survival in Renal Transplant Form Uncontrolled Donors After Circulatory Death (uDCD). [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/donor-age-50-years-and-cit-longer-than-18-hour-are-independent-risk-factors-for-one-year-graft-survival-in-renal-transplant-form-uncontrolled-donors-after-circulatory-death-udcd/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress