Background: Antibody-mediated rejection (ABMR) is an important cause of allograft dysfunction in short-term and long-term period. The complement component 4 (C4) and component 5 (C5) is considered to be pivotal in the complement system of the innate immune response, and be associated with the alloreative antibodies and donor-specific antibodies (DSAs). However, the effect of C4 and C5 genetic polymorphisms on the development of ABMR is still unclear.

Methods: Blood samples of renal transplant recipients with ABMR or stable graft function were collected, and studied by next-generation sequencing with an established gene panel. High quality readout was obtained in 9 single nuclear polymorphisms (SNPs) in C4 gene and 22 SNPs in C5 gene.

Results: 200 subjects containing 137 stable patients and 63 recipients with ABMR were included in our study. After adjusting with age, sex and immunosuppressive protocols, all SNPs in C4 and C5 genes have no statistical association with the pathogenesis of ABMR.

Conclusions: Our study observed for the first time that all SNPs of C4 gene or C5 gene are not significantly correlated with ABMR in renal transplant recipients. This finding may have implication for the diagnosis and prevention of ABMR, contributing to the promotion of the renal transplant outcomes.

CITATION INFORMATION: Wang Z, Han Z, Tao J, Tan R, Gu M. Single Nuclear Polymorphisms of Complement Component 4 and Component 5 in Renal Transplant Recipients with Antibody-Mediated Rejection. Am J Transplant. 2017;17 (suppl 3).

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