Circulating Soluble-Klotho Levels Modestly Increase After Renal Transplantation.

S.-J. Tan,¹ A. Crosthwaite,² D. Langsford,³ V. Obeysekere,⁴ F. Ierino,^2,5 M. Roberts,^5,6 S. Holt,¹ T. Hewitson,¹ K. Dwyer,^3,5,7 N. Toussaint.¹

¹Dept of Nephrology, The Royal Melbourne Hospital, Melbourne, Australia
²Dept of Nephrology, Austin Hospital, Heidelberg, Victoria, Australia
³Dept of Nephrology, St Vincent's Hospital, Melbourne, Australia
⁴Dept of Endocrinology, St Vincent's Hospital, Melbourne, Australia
⁵Victorian Kidney Transplantation Collaborative, Melbourne, Australia
⁶Dept of Renal Medicine, Eastern Health, Box Hill, Australia
⁷School of Medicine, Deakin University, Geelong, Australia.

Meeting: 2016 American Transplant Congress

Abstract number: B238

Keywords: Kidney transplantation

Session Information

Session Name: Poster Session B: Kidney: Cardiovascular and Metabolic

Session Type: Poster Session

Date: Sunday, June 12, 2016

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Background: Klotho, a co-receptor for FGF23, is predominantly expressed in kidney and reported to have anti-oxidant and anti-fibrotic properties. Soluble-Klotho (sKl), the cleaved circulating protein, declines dramatically with kidney disease and is inversely associated with mortality. Aim: To evaluate change in sKl over 12 months following kidney transplantation. Methods: Incident kidney transplant recipients (KTRs) were recruited with blood sampled at 4 time-points; pre-transplantation (baseline), 1-week, 12-weeks and 52-weeks post transplantation. Samples were assayed for basic biochemistry and sKl (IBL, Japan). Within-subject comparisons were evaluated using repeat-measure ANOVA/Friedman's test. Results: Samples from 29 KTRs were available for final analysis. Median KTR age was 49 (35-55) years. Seventeen (59%) were male, 26(90%) were living kidney allografts and 10 (34%) were pre-emptive. Table 1 summarises the change across the relevant measured parameters. Compared with baseline, sKl exhibited an increase at 52w following initial decline at 1w (p<0.005 and p<0.01 respectively). Conclusions: This prospective study demonstrated modest sKl increase post kidney transplantation despite excellent graft function achieved, suggesting factors beyond renal capacity influencing circulating sKl. Longer-term evaluation and investigation specifically addressing effects of immunosuppression on sKl are required.

Parameter	Baseline	1-week	12-weeks	52-weeks
sKlotho, pg/mL	307 (279-460)	273 (246-343)^b	352 (286-417)^c	460 (311-525)^a,c
Serum phosphate (sPi), mmol/L	1.78 ± 0.5	0.81 ± 0.29^a	0.88 ± 0.19^a	0.92 ± 0.17^a
Serum creatinine (sCr), umol/L	638 (537-722)	113 (92-142)^a	112 (99-130)^a	111 (97-131)^a
eGFR,ml/min/1.73m²	7.4 (6.5-8.7)	63.2 (46.5-87.4)^a	61.2 (51.7-71.9)^a	60.4 (50.5-71.6)^a
Data presented as Median (IQR) or Mean ± SD. Friedman test or repeat measures ANOVA performed. ^a p<0.005 c/w baseline. ^b p≤0.01 c/w baseline. ^cp<0.005 c/w 7-day.

CITATION INFORMATION: Tan S.-J, Crosthwaite A, Langsford D, Obeysekere V, Ierino F, Roberts M, Holt S, Hewitson T, Dwyer K, Toussaint N. Circulating Soluble-Klotho Levels Modestly Increase After Renal Transplantation. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Tan S-J, Crosthwaite A, Langsford D, Obeysekere V, Ierino F, Roberts M, Holt S, Hewitson T, Dwyer K, Toussaint N. Circulating Soluble-Klotho Levels Modestly Increase After Renal Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/circulating-soluble-klotho-levels-modestly-increase-after-renal-transplantation/. Accessed November 22, 2024.

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