2017 American Transplant Congress
Effective Thrombolytic Therapy of Hepatic Artery Thrombosis After Liver Transplantation – A Single-Center Experience.
BACKGROUND: Hepatic artery thrombosis (HAT) is a common complication of liver transplantation which causes lots of graft loss. The anastomoses of hepatic artery requires delicate…2017 American Transplant Congress
Mesenchymal Stem Cells Suppress T Cell Proliferation and Improve Allograft Survival in a Nonhuman Primate Transplant Model.
Emory Transplant Center, Emory University, Atlanta, GA
Background: The clinical implementation of costimulation blockade (CoB) provides long-term benefit to transplant recipients, with the short-term drawback of increased acute rejection. Cellular therapies are…2017 American Transplant Congress
Inhibition of Memory T Cell Alloresponses by TIM-1+ B Cells.
Background:Alloreactive memory T cells mediate accelerated rejection of allografts and prevent tolerance induction. While regulatory B cells (Bregs) can promote tolerance induction through suppression of…2017 American Transplant Congress
IVIg+Rituximab Desensitization (DES) Combined with Alemtuzumab (ATZ) Induction Does Not Increase Risk for Viral Infections (VIs) and Associated Complications in HLA-Sensitized (HS) Kidney Transplant Patients (KTx Pts).
Background: VIs represent significant morbidity factors in KTx pts. DES followed by KTx with ATZ induction increased successful Tx rates in HS pts, but may…2017 American Transplant Congress
Heat Shock Protein 90 Inhibitor, 17DMAG Suppresses Acute Allograft Rejection and Prolongs Allograft Survival in Solid Organ Transplantation.
Urology, Sapporo Medical University School of Medicine, Sapporo, Japan
Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…2017 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Activation.
University of Maryland, Baltimore
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…2017 American Transplant Congress
Immunosuppressive Role of Pancreas Derived Mesenchymal Stem Cells.
BackgroundThe Edmonton protocol revived islet transplantation therapy for Type-1 Diabetic patients. However, Long-term islet function still remains a challenge. Immunosuppression used after islet transplantation contributes…2017 American Transplant Congress
T Cell Responses to Viral Peptide Stimulation Predict Influenza Vaccine-Induced Seroconversion in Pediatric Solid Organ Transplant Recipients.
Introduction: Biomarkers predictive of vaccine response are needed to determine the optimal timing of immunization post-transplantation. We previously found that low T-cell ELISPOT responses to…2017 American Transplant Congress
Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).
RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…2017 American Transplant Congress
Blockade of Tim-3 and PD-1 Reverses Dysfunctions of Tumor Infiltrating Lymphocytes in HBV Related Hepatocellular Carcinoma.
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The immunosuppression of tumor infiltrating lymphocytes (TILs) is associated with rapid progress of hepatitis B virus related hepatocellular carcinoma (HBV-HCC). The inhibition molecules of T…
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