2017 American Transplant Congress
Serva NB1 versus Vitacyte Collagenase: Comparable Human Islet Isolation Outcomes Using DCD Donor Pancreas in China.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective This study was designed to retrospectively compare the effect of Serva NB1 collagenase between Vitacyte collagenase on islet isolation of DCD pancreas in China.…2017 American Transplant Congress
Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.
BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…2017 American Transplant Congress
Total Pancreatectomy and Islet Autotransplantation into the Liver of a Patient with Previous Hepatitis C Infection.
Hepatic parenchymal disease such as hepatitis has been considered a relative contraindication to islet transplantation as the islets are infused into the liver. Islet transplantation…2017 American Transplant Congress
Maintenance of the Phenotype and Abundance of Islet-Resident Macrophages Promotes Islet Graft Survival and Appears to Prevent Type 1 Diabetes.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Immunoregulatory tissue resident macrophage subsets have been reported in skin, heart, lung and adipose tissue.We now demonstrate the existence of a functionally immunoregulatory population of…2017 American Transplant Congress
Hypoxia Induces Tissue Factor Upregulation in Isolated Human Islets.
1Imperial College, London, United Kingdom; 2King's College, London, United Kingdom
Purpose: Early islet loss post-infusion remains a significant problem in islet transplantation, despite the use of heparinised media to abrogate the effects of Tissue Factor…2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…2017 American Transplant Congress
Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.
Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
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