2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…2020 American Transplant Congress
Generation of Insulin-Producing Cells via Multiplex Epigenetic Engineering of Human Somatic Cells in 2 Weeks
*Purpose: Stem cell-derived β-cells not only promise a renewable supply of insulin-producing cells with negligible immunosuppression but may also provide a substrate for the identification…2019 American Transplant Congress
Donor Insulin Therapy Predicts Better Graft Survival in Pancreas Transplantation
University of Manchester, Manchester, United Kingdom
*Purpose: Organ donors frequently develop hyperglycaemia in intensive care, which is managed with insulin. In islet and solid pancreas transplantation (PT) we reported that Donor…2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…2019 American Transplant Congress
Assessment of Culture/Preservation Conditions on Survival and Function of Islets
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: Culture or preservation of human islets prior to transplantation has been adopted by various centers because it may reduce immunogenicity, suppress exocrine contamination and…2019 American Transplant Congress
Microfluidic Study Analyzing the Effect of Immediate-Release and Extended-Release Tacrolimus on Islet Function
*Purpose: The purpose of this analysis was to quantify the impact of 2 tacrolimus pharmacokinetic profiles on functional changes within human islet cells using a…2019 American Transplant Congress
Insulin Treatment in Pancreas Donors on the Intensive Care is a Marker of Beta Cell Death as Evidenced by microRNA Data
University of Manchester, Manchester, United Kingdom
*Purpose: We showed in prior studies that donor insulin use on intensive care predicts early beta cell dysfunction in islet and solid pancreas transplantation. We…2019 American Transplant Congress
Kidney Transplantation after Sleeve Gastrectomy in the Morbidly Obese Candidate: Results of a Five-Year Experience
Department of Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Morbid obesity serves as a barrier to kidney transplantation (KT) due to potential suboptimal post-transplant outcomes. Laparoscopic sleeve gastrectomy (LSG) has previously been shown…2019 American Transplant Congress
Outcomes of Total Pancreatectomyand Islet Autotransplantation, a Single Center Experience
*Purpose: Patients with chronic pancreatitis (CP) suffer from severe pain that greatly reduces their quality of life and often leads to long-term narcotic therapy to…2019 American Transplant Congress
Comparison of Functional β-cell Function and Insulin Sensitivity of Functioning Pancreas Transplant According to Pre-Transplant Matsuda’s Index
*Purpose: This study was performed to verify post-transplant improvement of functioning β-cell mass and insulin sensitivity of functioning pancreas transplants according to the degree of…