2016 American Transplant Congress
The First Impressions: A Study in Pre and Post-Implantation Renal Grafts for Early Detection Markers of Delayed Graft Function and Recovery.
1UVA, Charlottesville; 2VCU, Charlottesville; 3Northwestern University, Chicago.
Background: Delayed graft function (DGF) is mainly a consequence of ischemia and reperfusion injury (IRI) resulting in acute tubular necrosis. The degree of IRI is…2016 American Transplant Congress
Non-Invasive Biomarkers for Graft Quality and Outcome Post-Liver Transplantation.
Surgery, UVA, Charlottesville, VA.
Background: Graft quality is a determinant of graft function after liver transplantation (LT). This study aimed to evaluate graft molecular markers that correlate to peripheral…2016 American Transplant Congress
DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.
Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…2015 American Transplant Congress
Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers
Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…2015 American Transplant Congress
APOL1 Risk Alleles in Live and Deceased Kidney Donors Are Associated With Shorter Renal Allograft Survival
Kidneys from African American (AA) donors with two Apolipoprotein L1 (APOL1) risk alleles may be at higher risk of allograft loss after transplant. We sought…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…2015 American Transplant Congress
Incorporating Markers of Donor Organ Intrinsic Biology Into Donor Quality Evaluation
UVA, Charlottesville, VA; Northwestern University, Chicago, IL; VCU, Richmond, VA.
Background. We aimed to identify a reliable composite scoring system (clinical / biological) to evalute organ quality and predict outcomes post-kidney transplantation (KT).Methods. 233 deceased…2015 American Transplant Congress
The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation
Over 570,000 solid organ transplants have been performed in the United States since 1988. Despite significant improvements in transplant outcomes, chronic organ rejection affects up…2015 American Transplant Congress
The Association Between Donor & Recipient Gene Variants and Tacrolimus Safety & Efficacy in a Diverse Cohort of Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC.
Previous studies have associated donor P-glycoprotein (PGP) gene variants (ABCB1) with risk of developing CNI-toxicity, while also establishing recipient CYP3A5*1 and ABCB1 gene variants are…
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