2015 American Transplant Congress
The Use of Systems Biology to Identify Mitochondrial Dysfunction and Metabolic Dysregulation as Targets for Intervention in the Brain Dead Organ Donor
Oxford Transplant Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom.
Introduction: Due to the persistent donor shortage many centres accept older, higher risk organs which have inferior outcomes. Understanding how kidneys are injured during brain…2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…2015 American Transplant Congress
Decreased Expression of Mitochondrial Aldehyde Dehydrogenase 2 Induces Liver Injury Via Activation of the MAPK Pathway in Grafts from Brain-Dead Donors
Objective: To determine the role of ALDH2 in the injury of liver from brain-dead donors.Methods: Using brain-dead rabbit model, the expression of ALDH2 and apoptosis…2015 American Transplant Congress
The Impact of Duration of Brain Death on Outcomes in Abdominal Organ Transplantation: Rush and Retrieve or Rather Relax and Repair?
Background: Brain death (BD) induces a progressive systemic pro-inflammatory and coagulatory response affecting function of the grafts-to-be and survival. With longer BD duration more injury…2015 American Transplant Congress
Enhanced Production of Macrophage Chemoattractant Protein-1 (MCP-1) Within the Kidney in Brain Death Donors Predicts Recipient Allograft Function
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Brain death (BD) induces an intense pro-inflammatory state, which may impact recipient immunity and graft function after kidney transplantation. The identification of biomarkers predictive of…2015 American Transplant Congress
Remote Ischemic Preconditioning Increases Transplantation of Abdominal Organs in Standard Criteria Neurological Death Donors
Background: Remote ischemic preconditioning (RIPC) induces innate protective mechanisms in remote organs. We hypothesized RIPC soon after neurological death (ND) would improve donor organ function…2015 American Transplant Congress
Speed of Onset of Donor Brain Death Leads to Differences in Renal Function and Expression of Inflammatory and Oxidative Stress Markers in Rat Kidneys
IntroductionDonor brain death (BD) is an independent risk factor for primary and delayed renal graft function. Furthermore, the speed of onset of brain death, traumatic…2015 American Transplant Congress
Anti-Apoptotic But Not Mitotic Effects of 3,3',5-triiodo-l-thyronine in the Liver of Brain Dead Rats
Thyroid hormone treatment in brain dead organ donors has been extensively studied and applied in the clinical setting. However, its effectiveness remains controversial due to…
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