2018 American Transplant Congress
Myeloid Derived Suppressor Cells Are Induced after Transplantation and Home to the Transplanted Kidney
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a naturally occurring, heterogeneous population of highly immunosuppressive cells which expand in response to inflammatory conditions such as cancer.…2018 American Transplant Congress
Anti-Thymocyte Globulin Directly Binds and Functionally Inhibits Allo-Regulatory Myeloid Derived Suppressor Cells
Surgery and Immunology, University of Maryland, Baltimore, MD.
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of naturally occurring, immunosuppressive cells that may be exploitable in transplantation.There are only a few incomplete…2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…2018 American Transplant Congress
Immune Profiling in Highly Sensitized Kidney Transplant Recipients
Surgery, McGill University, Montreal, Canada.
Introduction: Highly sensitized patients (HSP) express foreign HLA antibodies and have poor graft survival due to higher incidences of graft rejection as compared to non-sensitized…2017 American Transplant Congress
Extracellular Mitochondria Cause B7 Costimulation Blockade Resistant Allograft Rejection in Mice.
1Surgery, Duke University, Durham, NC; 2Immunology, Duke University, Durham, NC
Introduction: Mitochondria released in the setting of tissue injury and cell death are a source of damage-associated molecular patterns that activate innate immune responses. We…2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…2017 American Transplant Congress
FcγRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+ T Cell Responses.
Emory Transplant Center, Emory University, Atlanta, GA
Memory T cells can be a formidable barrier to long-term, rejection-free allograft survival, particularly in the setting of costimulation blockade. Ongoing work in the field…2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…2017 American Transplant Congress
Nephrectomy of the Failed First Kidney Allograft Predisposes Kidney Transplant Recipients to Presensitization with Alloreactive T-Cells and Inferior Allograft Survival After Retransplantation.
During the last two decades the number of recipients (KTRs) of a previous kidney transplantation being evaluated and waitlisted for a subsequent kidney transplantation has…2017 American Transplant Congress
Donor SIRPa Polymorphism Modulates the Innate Immune Response to Allogeneic Grafts.
Mice devoid of T, B, NK, and innate lymphoid cells distinguish between self and allogeneic non-self despite the absence of an adaptive immune system. When…
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