2016 American Transplant Congress
The Effect of Donor Age on Acute Rejection Age – The Clinical Impact of Donor Immuno-Senescence in the Modern Immunosuppressive Era.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Experimental work has shown that donor age may alter the immune response of the recipient so that older donor grafts elicit a stronger response in…2016 American Transplant Congress
Dendritic Cells and Damage-Associated Molecular Patterns in Aging.
Recently, it has been shown that Dendritic Cells (DCs) of old organs accelerate graft rejection by orchestrating IL-17A-mediated T cell responses. Moreover, cell-free DNA has…2016 American Transplant Congress
Acute Rejection Profoundly Impacts Graft Survival in Young but Not in Old Kidney Transplant Recipients.
Background: The proportion of marginal grafts and elderly recipients awaiting kidney transplantation is ever increasing. The correlation of age with DGF and acute rejection determines…2016 American Transplant Congress
Clinical Prediction Tool to Guide Referral of Elderly Dialysis Patients for Kidney Transplant Evaluation.
Background: Adults over 70 years old are the fastest growing segment of the end stage renal disease (ESRD) population. Due to substantial variation in co-morbidities…2016 American Transplant Congress
End Stage Renal Disease Patients Have a Skewed T Cell Receptor Vbeta Repertoire.
IntroductionEnd stage renal disease (ESRD) is associated with a defective T-cell mediated immunity, resembling premature T-cell ageing. A diverse T-cell receptor Vbeta (TCR Vβ) repertoire…2016 American Transplant Congress
Ageing as a Barrier to Transplant Tolerance.
Surgery/Transplant, Massachusetts General Hospital, Harvard Medical, Boston, MA.
We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 12…2016 American Transplant Congress
Impact of Social Support on Feelings of Powerlessness and Attitudes Towards the Kidney Transplant in Long-Term Inner City Recipients.
Medicine, SUNY Downstate Medical Center, Brooklyn, NY.
Psychosocial factors play an important role in the post-transplant period, affecting adherence and quality of life. We investigated the relationships between social support, attitude towards…2016 American Transplant Congress
Profiling Immunologic Risk for Acute Rejection in Liver Transplantation: Recipient Age Is a Robust Risk Factor.
Profiling the immunologic risk for acute rejection in liver transplantation (OLT) may allow for selection immunosuppression (IS) target ranges appropriate to risk levels, all with…2016 American Transplant Congress
Watch Out for the Guy with the Low EPTS Score: Nonadherence and Kidney Allograft Failure.
Medicine, University Hospitals Case Medical School, Cleveland, OH.
Background: Nonadherence is a known cause of rejection and kidney allograft failure. Our aim was to define risk factors for allograft loss related to nonadherence.…2016 American Transplant Congress
Survival After Second Kidney Transplant: Are We Being Good Stewards?
University of Texas Health Science Center, San Antonio.
BACKGROUND: Primary kidney transplant is associated with increased life years compared with dialysis. Comparable patient survival between primary (1KT) and second kidney transplants (2KT) has…
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