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2022 American Transplant Congress

TOPIC: Basic Science » Basic Science » 02 - Acute Rejection

  • Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes

    J. Callemeyn1, B. Lamarthée1, P. Koshy2, T. Debyser3, E. Van Loon1, A. Franken4, T. Van Brussel4, I. Arijs4, D. Lambrechts4, M. Rabant5, A. Senev1, T. Vaulet6, C. Tinel1, M. Naesens1

  • LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody

    A. Boshart1, S. Farkona1, S. Clotet-Freixas1, C. McEvoy1, J. Murphy1, S. Crome2, A. Konvalinka3

  • M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod

    M. Zheng1, W. Zijie2, Z. Gui3, R. Tan1, M. Gu3

  • Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes

    A. Ahmed1, L. Allegretti2, C. Rebello3, B. Kinsella3, K. Guo3, S. Park4, J. Friedewald3

  • p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts

    H. Tsuda1, A. Valujskikh2, R. Fairchild3

  • Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection

    Y. Mitsui1, D. Ueda1, S. Miyairi1, N. Dvorina1, K. S. Keslar1, A. Valujskikh1, B. William1, R. Fairchild2

  • Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft

    D. Okada, S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. Baldwin, R. Fairchild

  • Renal Allograft Rejection: New Paradigms in the T Cell Landscape Revealed by Single Cell RNAseq Analysis

    T. Shi1, A. Burg1, K. Roskin2, J. Rush3, B. Haraldsson3, A. Shields4, R. Alloway4, E. Woodle5, D. Hildeman1

  • Single Cell RNAseq Analysis of Liver Transplant Rejection Reveals Highly Restricted TCR Clonal Expansion of Tissue-Resident Memory CD8+ T Cells That Persist Despite Corticosteroids and ATG Therapy

    A. L. Peters1, G. Begum1, K. Roskin2, E. Woodle3, D. Hildeman4

  • Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health

    M. Rao1, M. Amouzgar1, J. T. Harden1, M. Lapasaran1, A. Trickey1, B. Armstrong2, J. Odim3, T. Debnam3, C. Esquivel1, S. C. Bendall1, O. Martinez1, S. M. Krams1

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