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Articles tagged "Xenotransplantation"

  • 2015 American Transplant Congress

    Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs

    A. Salama,1,2 S. Conchon,1 A. Perota,3 B. Martinet,1 J.-P. Judor,1 G. Evanno,1 S. Le-Bas Bernardet,1 L. Le Berre,1 J. Hervouet,1 D. Minault,1 J.-P. Concordet,4 E. Dugast,1 B. Vanhove,1 J. Abadie,5 N. Gaide,5 I. Lagutina,3 R. Duchi,3 G. Lazzari,3 D. Sachs,6 O. Gauthier,7 S. Brouard,1 E. Cozzi,8 G. Blancho,1 H. Perreault,9 J.-M. Bach,10 C. Galli,3,11 J.-P. Soulillou.1

    1INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; 3Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; 4INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; 5AMaROC, ONIRIS, Nantes, France; 6Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; 7Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; 8Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; 9Chemistry Department, University of Manitoba, Winnipeg, Canada; 10IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; 11Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

    Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
  • 2015 American Transplant Congress

    Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact

    E. Montanari,1 R. Mahou,1,2 S. Passemard,2 F. Noverraz,2 P. Morel,1 R. Meier,1 D. Bosco,1 J. Seebach,3 C. Wandrey,2 S. Gerber,2 C. Gonelle-Gispert,1 L. Buhler.1

    1Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; 2Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 3Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.

    Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
  • 2015 American Transplant Congress

    Infusion of Human Factor 7a Restores Circulating Platelets and Prevents TMA in Pig-to-Baboon Liver Xenotransplantation

    J. Shah, N. Navarro-Alvarez, H. Yeh, N. Elias, J. Ligocka, J. Markmann, M. Hertl, D. Sachs, P. Vagefi.

    Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA.

    Background We sought to determine the effects of exogenous administration of human coagulation factors in a pig-to-baboon model of liver xenotransplantation (LXT).Methods LXT was performed…
  • 2015 American Transplant Congress

    Cardiac Xenotransplantation: Reconstituted B Cells After Rituxan Treatment Maintain Their Repertoire But Have a Muted Response to Xenoantigens

    A. Singh,1 P. Corcoran,1 B. Lewis,2 M. Thomas,2 D. Ayers,3 K. Horvath,1 M. Mohiuddin.1

    1CSRP/NIH/NHLBI, NIH, Bethesda, MD; 2DVR/ORS, NIH, Bethesda, MD; 3Revivicor Inc, Blacksburg, VA.

    Background: Xentoranplantation (XTx) remains an option for end stage organ failure. Recently we have reported cardiac xenograft survival of over one year pig to baboon…
  • 2015 American Transplant Congress

    Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation

    M. Ketaki,1 P. Pradeep,1 N. Nikhil,1 G. Dellgren,3 H. Suchitra, M. Olausson.2

    1Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; 2Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; 3Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

    Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
  • 2015 American Transplant Congress

    Effects of Immunosuppressives On Porcine Renal Microvascular Endothelial Cell–Activated Human T Cell Proliferation: A Cellular Model of Kidney Xenotransplantation In Vitro

    Z.-Y. Wang, M. Tector, S. Nagai, J. Butler, R. Blankenship, S. Downey, J. Estrada, P. Li, A. Tector.

    Surgery, Indiana University School of Medicine, Indianapolis, IN.

    Background: The creation of genetically-modified pigs has brought us closer than ever to clinical xenotransplantation. However, the optimal immunosuppressive doses still need to be established…
  • 2015 American Transplant Congress

    Activation and Sequestration of Platelets During Xenogeneic GalTKO.hCD46 Pig Lung Perfusion Is Primarily Mediated By GPIb, GPIIb/IIIa, and VWF

    L. Burdorf,1 A. Riner,1 A. Shah,1 E. Schwartz,1 K. Quinn,1 E. Kang,1 E. Sievert,1 E. Rybak,1 D. Harris,1 T. Zhang,1 D. Parsell,1 X. Cheng,1 G. Braileanu,1 S. De Meyer,2 I. Salles,2 H. Deckmyn,2 C. Phelps,3 D. Ayares,3 R. Pierson III,1 A. Azimzadeh.1

    1Surgery, University of Maryland, Baltimore, MD; 2Laboratory for Thrombosis Research, IRF-Ls, Kulak KU Leuven, Leuven, Belgium; 3Revivicor, Inc., Blacksburg, VA.

    Background: Xenogeneic pig lung perfusion with human blood leads to the initiation of rejection mechanisms that are associated with the immediate sequestration of circulating platelets.…
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