Articles tagged "Xenotransplantation"

2015 American Transplant Congress
Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments
L. Burdorf,¹ E. Rybak,¹ T. Zhang,¹ D. Harris,¹ S. Dahi,¹ N. Kubicki,¹ D. Parsell,¹ E. Sievert,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III.¹
¹University of Maryland, Baltimore; ²Revivicor, Blacksburg.
Purpose: Prolonged life-supporting (LS) xenolung function has proven difficult to accomplish. Here we report results from 21 xLTXs in a rigorous, LS pig-to-baboon model, asking…
2015 American Transplant Congress
Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice
N. Nayakawde, P. Patil, K. Methe, M. Olausson.
Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.
Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
K. Samy,¹ B. Martin,² P. Thompson,² A. Farris,² M. Song,² V. Leopardi,¹ B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory Transplant Center, Emory University, Atlanta, GA.
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…
2015 American Transplant Congress
Detergent-Sonication Method for the Whole Laryngeal Decellularization
N. Nayakawde,¹ K. Methe,¹ M. Berg,² G. Premaratne,¹ H. Ejnell,² M. Olausson.¹
¹Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden; ²Departments of 1Otolaryngology, Head and Neck Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.
Background: Each year, about 136,000 individuals worldwide are diagnosed with larynx carcinoma. Tissue engineered organs shows promising alternative to a conventional transplantation in both preclinical…
2015 American Transplant Congress
Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs
A. Salama,^1,2 S. Conchon,¹ A. Perota,³ B. Martinet,¹ J.-P. Judor,¹ G. Evanno,¹ S. Le-Bas Bernardet,¹ L. Le Berre,¹ J. Hervouet,¹ D. Minault,¹ J.-P. Concordet,⁴ E. Dugast,¹ B. Vanhove,¹ J. Abadie,⁵ N. Gaide,⁵ I. Lagutina,³ R. Duchi,³ G. Lazzari,³ D. Sachs,⁶ O. Gauthier,⁷ S. Brouard,¹ E. Cozzi,⁸ G. Blancho,¹ H. Perreault,⁹ J.-M. Bach,¹⁰ C. Galli,^3,11 J.-P. Soulillou.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; ⁴INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; ⁵AMaROC, ONIRIS, Nantes, France; ⁶Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; ⁷Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; ⁸Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; ⁹Chemistry Department, University of Manitoba, Winnipeg, Canada; ¹⁰IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ¹¹Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
E. Montanari,¹ R. Mahou,^1,2 S. Passemard,² F. Noverraz,² P. Morel,¹ R. Meier,¹ D. Bosco,¹ J. Seebach,³ C. Wandrey,² S. Gerber,² C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; ²Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
2015 American Transplant Congress
Infusion of Human Factor 7a Restores Circulating Platelets and Prevents TMA in Pig-to-Baboon Liver Xenotransplantation
J. Shah, N. Navarro-Alvarez, H. Yeh, N. Elias, J. Ligocka, J. Markmann, M. Hertl, D. Sachs, P. Vagefi.
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA.
Background We sought to determine the effects of exogenous administration of human coagulation factors in a pig-to-baboon model of liver xenotransplantation (LXT).Methods LXT was performed…