Articles tagged "Warm ischemia"

2021 American Transplant Congress
Donation After Cardiac Death (DCD) Agonal Phase Physiology is Associated with Post-transplant Kidney Graft Outcomes
A. Kayastha¹, K. C. Eddinger², E. M. Sonnenberg², N. Mahmud², D. E. Schaubel¹, P. L. Abt²
¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Kidneys procured from DCD donors play a key role in addressing the kidney shortage in the United States, and donor hemodynamics during obligatory warm…
2021 American Transplant Congress
Hypoperfusion Warm Ischaemia Time in Renal Transplants from Donors After Circulatory Death
I. D. Kostakis¹, T. Kassimatis¹, C. Flach², N. Karydis¹, N. Kessaris¹, I. Loukopoulos¹
¹Department of Transplantation, Guy’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, ²School of Population Health and Environmental Studies, King’s College London, London, United Kingdom
*Purpose: Donor hypoperfusion before asystole in renal transplants from donors after circulatory death (DCD) has been considered responsible for worse outcomes than those from donors…
2020 American Transplant Congress
DCD vs DBD Liver Transplantation: Equivalent Charges and Similar Survival- An Effective Expansion of the Donor Pool
N. Singh, K. Helfrich, M. Alebrahim, C. Akateh, K. Mumtaz, A. Logan, A. Schenk, S. Black, E. Elkhammas, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: The shortage of allografts available for liver transplantation (LT) has prompted the need for expansion of donor pool to include donation after circulatory death…
2020 American Transplant Congress
Activation of YAP Attenuates Hepatic Damage and Fibrosis in Liver Ischemia-Reperfusion Injury: From Bench to Bedside
Y. Liu¹, T. Lu², C. Zhang¹, Z. Xue¹, R. Busuttil¹, J. Kupiec-Weglinski¹, H. Ji¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Shanghai Jiaotong University, Shanghai, China
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver resection and transplantation. YAP, the effector of Hippo pathway, is essential in…
2020 American Transplant Congress
Genome-Wide Transcriptome Analysis of Extreme Marginal Renal Grafts Indicates Earlier Repair and Less Damage Following Normothermic Ex-Vivo Kidney Perfusion Preservation
P. Urbanellis¹, L. Mazilescu¹, C. McEvoy¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson¹, M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) was shown to prevent delayed graft function of kidneys subjected to prolonged warm ischemia (WI) compared to static cold…
2020 American Transplant Congress
Potential to Regenerate Damaged Allografts
L. Brasile¹, B. Stubentisky²
¹Research and Development, Breonics Inc., Watervliet, NY, ²Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands
*Purpose: The chronic shortage of allografts has generated intense interest in the field of regenerative medicine. Given the limited regeneration that can be accomplished in…
2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
S. Cai¹, S. Wang², W. Zhang², A. Chandraker¹, C. Yang², T. Zhu²
¹Renal Division, Brigham and Women's Hospital, Boston, MA, ²Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
2020 American Transplant Congress
Short Recipient Warm Ischemia Time Improves Graft Survival in Liver Transplantation from Donation after Brain Death: 20-Year Experience of Liver Transplantation
A. Al-Kurd, T. Kitajima, K. Delvecchio, A. M. Elsabbagh, S. Yeddula, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, S. Nagai
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Although the correlation between warm ischemia time (WIT) and the outcomes of liver transplantation has been extensively studied, few investigations have focused on the…
2020 American Transplant Congress
Benefits of Normothermia Regional Perfusion (NRP), Hypothermic Machine Perfusion (HMP) and Short Cold Ischemia Time (CIT) for Kidney Transplants with Controlled Donation after Circulatory Death (cDCD)
E. Savoye¹, C. Legeai¹, J. Branchereau², S. Gay³, S. Drouin⁴, F. Gaudez⁵, B. Veber⁶, J. Venhard⁷, G. Cheisson⁸, T. Kerforne⁹, O. Bastien¹, C. Antoine¹
¹Agence de la Biomedecine, La Plaine Saint Denis, France, ²CHU Nantes, Nantes, France, ³CH Annecy, Annecy, France, ⁴CHU Pitié Salpetriere, Paris, France, ⁵CHU Saint Louis, Paris, France, ⁶CHU Rouen, Rouen, France, ⁷CHU Tours, Tours, France, ⁸CHU Kremlin-Bicetre, Kremlin-Bicetre, France, ⁹CHU Poitiers, Poitiers, France
*Purpose: cDCD are considered as extended criteria donors with poorer kidney transplant outcomes and high delayed graft function (DGF) rate. We built a French national…
2020 American Transplant Congress
Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
J. Kim, C. Lee, W. Chapman
Surgery, Washington University St. Louis, St. Louis, MO
*Purpose: Aged livers are far more susceptible to ischemia/reperfusion (I/R) injury than young livers. No therapeutic strategies are available to reduce I/R injury in elderly…