ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2022 American Transplant Congress

    Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK

    H. Zhang1, M. Ni2, J. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, W. Li3, X. Wang2, Y. E. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3China-Japan Union Hospital of Jilin University, JiLing, China

    *Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…
  • 2022 American Transplant Congress

    A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury

    K. Hansen1, J. Wall2

    1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA

    *Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…
  • 2022 American Transplant Congress

    Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping

    O. C. Rodriguez1, J. R. Liggett2, J. Kang2, K. Loh2, Y. Lee1, N. Sang1, B. He1, Y. Cui2, K. Oza2, D. Kwon3, B. Kallakury3, T. Fishbein2, W. Cui2, K. Khan2, C. Albanese1, A. Kroemer2

    1Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Pathology, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
  • 2022 American Transplant Congress

    Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis

    I. Husain, A. Dangi, X. Luo

    Duke University School of Medicine, Durham, NC

    *Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
  • 2022 American Transplant Congress

    Early Outcomes for Liver Transplant with Thoracoabdominal Normothermic Regional Perfusion for Donation After Circulatory Death: A Multi-Center Experience

    A. L. Brubaker1, A. Lee1, B. Jackson1, J. Berumen1, J. R. Parekh1, K. L. Mekeel1, A. R. Gupta2, J. M. Gardner2, T. Chaly3, A. K. Mathur4, C. Jadlowiec4, K. Reddy4, R. Nunez4, J. Bellingham5, E. Thomas6, J. R. Wellen7, M. Kearns1, V. Pretorius1, G. T. Schnickel1

    1UC San Diego, San Diego, CA, 2UC San Francisco, San Francisco, CA, 3Arizona Transplant Associates, Phoenix, AZ, 4Mayo Clinic Arizona, Phoenix, AZ, 5California Pacific Medical Center, Orinda, CA, 6University of Texas, San Antonio, TX, 7Washington University, Saint Louis, MO

    *Purpose: We evaluated early outcomes of liver transplant after thoracoabdominal normothermic regional perfusion (TA-NRP) for controlled donation after circulatory death (cDCD) donors.*Methods: We identified liver…
  • 2021 American Transplant Congress

    The Impact of Combined Warm and Cold Ischemia Times on Post Transplant Outcomes

    M. E. Foley1, A. J. Vinson2, K. K. Tennankore2

    1Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, 2Division of Nephrology, Medicine, Dalhousie University/ Nova Scotia Health, Halifax, NS, Canada

    *Purpose: Both prolonged warm ischemia time (WIT) and cold ischemia time (CIT) have been associated with an increased risk of graft failure following kidney transplantation,…
  • 2021 American Transplant Congress

    Beneficial Effects of Argon Inhalation on Reducing Lung Ischemia-reperfusion Injury in Miniature Swine

    H. Sahara

    Div. Organ Replacement and Xeno Tx, Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    *Purpose: Noble gases, such as xenon and argon (Ar), are chemically inert but have shown to have cytoprotective effect. In contrast to xenon, Ar is…
  • 2021 American Transplant Congress

    Hypoxia Inducible Factor 1á (HIF-1á) Regulates Carcinoembryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) Splice Isoforms to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation

    K. J. Dery, H. Kojima, K. Kadono, H. Hirao, J. W. Kupiec-Weglinski

    The Dumont-UCLA Transplantation Center, Los Angeles, CA

    *Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
  • 2021 American Transplant Congress

    Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model

    C. S. O'Brien1, P. Hernandez1, Z. Wang1, G. Ge1, A. Kozikowski2, W. Hancock1, M. H. Levine1

    1University of Pennsylvania, Philadelphia, PA, 2University of Illinois at Chicago, Chicago, IL

    *Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
  • 2021 American Transplant Congress

    Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability

    S. Raigani1, S. Baptista1, A. Ohman2, J. Santiago2, I. Rosales1, M. Heaney2, J. Boylan2, T. Coe1, K. Uygun1, J. Sanders2, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Pediatric Endocrinology, Brown University, Providence, RI

    *Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
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