Articles tagged "Warm ischemia"

2022 American Transplant Congress
Early Outcomes for Liver Transplant with Thoracoabdominal Normothermic Regional Perfusion for Donation After Circulatory Death: A Multi-Center Experience
A. L. Brubaker¹, A. Lee¹, B. Jackson¹, J. Berumen¹, J. R. Parekh¹, K. L. Mekeel¹, A. R. Gupta², J. M. Gardner², T. Chaly³, A. K. Mathur⁴, C. Jadlowiec⁴, K. Reddy⁴, R. Nunez⁴, J. Bellingham⁵, E. Thomas⁶, J. R. Wellen⁷, M. Kearns¹, V. Pretorius¹, G. T. Schnickel¹
¹UC San Diego, San Diego, CA, ²UC San Francisco, San Francisco, CA, ³Arizona Transplant Associates, Phoenix, AZ, ⁴Mayo Clinic Arizona, Phoenix, AZ, ⁵California Pacific Medical Center, Orinda, CA, ⁶University of Texas, San Antonio, TX, ⁷Washington University, Saint Louis, MO
*Purpose: We evaluated early outcomes of liver transplant after thoracoabdominal normothermic regional perfusion (TA-NRP) for controlled donation after circulatory death (cDCD) donors.*Methods: We identified liver…
2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
J. Kang, J. Liggett, K. Oza, Y. Cui, K. Loh, D. Kwon, B. Kallakury, T. Fishbein, W. Cui, K. Kahn, A. Kroemer
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…
2022 American Transplant Congress
Complex Donor Transfer and Organ Procurement Organization Collaboration to Reduce Ischemia Time in Combined Face and Bilateral Hand Transplant
J. Trilles¹, D. Boczar¹, B. F. Chaya¹, Z. P. Berman¹, G. K. Diep¹, R. Rodriguez Colon¹, D. J. Ceradini¹, E. D. Rodriguez¹, B. E. Gelb²
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: We present a complex donor transfer protocol that places the donor at the recipient hospital prior to allograft procurement in order to reduce ischemia…
2022 American Transplant Congress
Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia
V. Boominathan¹, M. Willman¹, N. Battula², A. Zarrinpar¹, S. Duarte¹
¹University of Florida, Gainesville, FL, ²University of Oklahoma, Oklahoma City, OK
*Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…
2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery¹, H. Kojima¹, K. Kadono², H. Hirao¹, J. Kupiec-Weglinski³
¹UCLA, Los Angeles, CA, ²Liver Transplant Surgery, UCLA, Los Angeles, CA, ³UCLA Medical Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
2021 American Transplant Congress
Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model
C. S. O'Brien¹, P. Hernandez¹, Z. Wang¹, G. Ge¹, A. Kozikowski², W. Hancock¹, M. H. Levine¹
¹University of Pennsylvania, Philadelphia, PA, ²University of Illinois at Chicago, Chicago, IL
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2021 American Transplant Congress
Donation After Cardiac Death (DCD) Agonal Phase Physiology is Associated with Post-transplant Kidney Graft Outcomes
A. Kayastha¹, K. C. Eddinger², E. M. Sonnenberg², N. Mahmud², D. E. Schaubel¹, P. L. Abt²
¹Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Kidneys procured from DCD donors play a key role in addressing the kidney shortage in the United States, and donor hemodynamics during obligatory warm…
2021 American Transplant Congress
Hypoperfusion Warm Ischaemia Time in Renal Transplants from Donors After Circulatory Death
I. D. Kostakis¹, T. Kassimatis¹, C. Flach², N. Karydis¹, N. Kessaris¹, I. Loukopoulos¹
¹Department of Transplantation, Guy’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom, ²School of Population Health and Environmental Studies, King’s College London, London, United Kingdom
*Purpose: Donor hypoperfusion before asystole in renal transplants from donors after circulatory death (DCD) has been considered responsible for worse outcomes than those from donors…
2021 American Transplant Congress
The Impact of Combined Warm and Cold Ischemia Times on Post Transplant Outcomes
M. E. Foley¹, A. J. Vinson², K. K. Tennankore²
¹Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, ²Division of Nephrology, Medicine, Dalhousie University/ Nova Scotia Health, Halifax, NS, Canada
*Purpose: Both prolonged warm ischemia time (WIT) and cold ischemia time (CIT) have been associated with an increased risk of graft failure following kidney transplantation,…