2022 American Transplant Congress
Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…2022 American Transplant Congress
A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation
*Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…2022 American Transplant Congress
Lucas Device Assisted Uncontrolled Dcd Kidney Transplantation – A Feasible but Underutilized Option in the United States
Renal Transplant, Charleston Area Medical Center, Charleston, WV
*Purpose: Uncontrolled DCD (uDCD) procurement involves either normo-thermic or hypothermic regional perfusion to reduce ischemic injury. We report a series of successful kidney transplant utilizing…2022 American Transplant Congress
Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells
*Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…2022 American Transplant Congress
Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK
*Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…2022 American Transplant Congress
A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury
1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA
*Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…2022 American Transplant Congress
Early Outcomes for Liver Transplant with Thoracoabdominal Normothermic Regional Perfusion for Donation After Circulatory Death: A Multi-Center Experience
*Purpose: We evaluated early outcomes of liver transplant after thoracoabdominal normothermic regional perfusion (TA-NRP) for controlled donation after circulatory death (cDCD) donors.*Methods: We identified liver…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…
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