ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2022 American Transplant Congress

    Impact of Recipient Warm Ischemic Time on Outcomes Associated with High KDPI and DCD Donor Kidneys: Cold Ischemic Time Remains Paramount

    M. L. Jacobs, R. Stratta, M. Garner, B. Sharda, A. Farney, G. Orlando, A. Reeves-Daniel, C. Jay

    Department of Surgery, Atrium Health Wake Forest Baptist, Winston Salem, NC

    *Purpose: Previously we demonstrated that cold ischemic time (CIT) beyond 24 hours was an important risk predictor of early graft loss (EGL) and primary non-function…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients

    K. Dery1, H. Kojima2, H. Hirao2, K. Kadono3, T. Dong2, J. Kupiec-Weglinski4

    1Surgery, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, CA, 3Liver Transplant Surgery, UCLA, Los Angeles, CA, 4UCLA Medical Center, Los Angeles, CA

    *Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
  • 2022 American Transplant Congress

    A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation

    S. Hosgood1, C. Callaghan2, C. Wilson3, G. Oniscu4, B. Phillips5, L. Bates3, L. Smith6, M. L. Nicholson7

    1Surgery, University of Cambridge, Cambridge, United Kingdom, 2Transplant, Guys & St Thomas's, London, United Kingdom, 3Transplant, Freeman Hospital, Newcastle, United Kingdom, 4Edinburgh Royal Infirmary, Edinburgh, United Kingdom, 5Transplant, Guy's & St Thomas's, London, United Kingdom, 6NHSBT, NHSBT, Bristol, United Kingdom, 7University of Cambridge, Cambridge, United Kingdom

    *Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…
  • 2022 American Transplant Congress

    Lucas Device Assisted Uncontrolled Dcd Kidney Transplantation – A Feasible but Underutilized Option in the United States

    S. Nagaraju, S. Vaishnav, R. Savilla, M. Moore, J. B. Africa

    Renal Transplant, Charleston Area Medical Center, Charleston, WV

    *Purpose: Uncontrolled DCD (uDCD) procurement involves either normo-thermic or hypothermic regional perfusion to reduce ischemic injury. We report a series of successful kidney transplant utilizing…
  • 2022 American Transplant Congress

    Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells

    J. Zhang1, M. Ni1, H. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, J. Jin3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Guilin Medical University, Guilin, China

    *Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…
  • 2022 American Transplant Congress

    Gsk3beta Regulates the Resolution of Liver Ischemia Reperfusion Injury via MerTK

    H. Zhang1, M. Ni2, J. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, W. Li3, X. Wang2, Y. E. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3China-Japan Union Hospital of Jilin University, JiLing, China

    *Purpose: We have shown previously that glycogen synthase kinase β (Gsk3β) regulates liver inflammatory activation against ischemia/reperfusion injury (IRI). The question of whether it also…
  • 2022 American Transplant Congress

    A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury

    K. Hansen1, J. Wall2

    1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA

    *Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…
  • 2022 American Transplant Congress

    Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping

    O. C. Rodriguez1, J. R. Liggett2, J. Kang2, K. Loh2, Y. Lee1, N. Sang1, B. He1, Y. Cui2, K. Oza2, D. Kwon3, B. Kallakury3, T. Fishbein2, W. Cui2, K. Khan2, C. Albanese1, A. Kroemer2

    1Lombardi Comprehensive Cancer Center and the Center for Translational Imaging, Georgetown University Medical Center, Washington, DC, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Pathology, MedStar Georgetown University Hospital, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…
  • 2022 American Transplant Congress

    Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis

    I. Husain, A. Dangi, X. Luo

    Duke University School of Medicine, Durham, NC

    *Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…
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