ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2022 American Transplant Congress

    Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury

    J. Kang, J. Liggett, K. Oza, Y. Cui, K. Loh, D. Kwon, B. Kallakury, T. Fishbein, W. Cui, K. Kahn, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…
  • 2022 American Transplant Congress

    Complex Donor Transfer and Organ Procurement Organization Collaboration to Reduce Ischemia Time in Combined Face and Bilateral Hand Transplant

    J. Trilles1, D. Boczar1, B. F. Chaya1, Z. P. Berman1, G. K. Diep1, R. Rodriguez Colon1, D. J. Ceradini1, E. D. Rodriguez1, B. E. Gelb2

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: We present a complex donor transfer protocol that places the donor at the recipient hospital prior to allograft procurement in order to reduce ischemia…
  • 2022 American Transplant Congress

    Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia

    V. Boominathan1, M. Willman1, N. Battula2, A. Zarrinpar1, S. Duarte1

    1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK

    *Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…
  • 2022 American Transplant Congress

    CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation

    K. J. Dery1, H. Kojima1, K. Kadono2, H. Hirao1, J. Kupiec-Weglinski3

    1UCLA, Los Angeles, CA, 2Liver Transplant Surgery, UCLA, Los Angeles, CA, 3UCLA Medical Center, Los Angeles, CA

    *Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
  • 2022 American Transplant Congress

    Impact of Recipient Warm Ischemic Time on Outcomes Associated with High KDPI and DCD Donor Kidneys: Cold Ischemic Time Remains Paramount

    M. L. Jacobs, R. Stratta, M. Garner, B. Sharda, A. Farney, G. Orlando, A. Reeves-Daniel, C. Jay

    Department of Surgery, Atrium Health Wake Forest Baptist, Winston Salem, NC

    *Purpose: Previously we demonstrated that cold ischemic time (CIT) beyond 24 hours was an important risk predictor of early graft loss (EGL) and primary non-function…
  • 2022 American Transplant Congress

    Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device

    K. S. Hansen1, R. Meier2, J. Gardner1

    1University of California San Francisco, San Francisco, CA, 2Division of Transplant Surgery, University of Maryland, San Francisco, CA

    *Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
  • 2022 American Transplant Congress

    Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients

    K. Dery1, H. Kojima2, H. Hirao2, K. Kadono3, T. Dong2, J. Kupiec-Weglinski4

    1Surgery, UCLA, Los Angeles, CA, 2UCLA, Los Angeles, CA, 3Liver Transplant Surgery, UCLA, Los Angeles, CA, 4UCLA Medical Center, Los Angeles, CA

    *Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
  • 2022 American Transplant Congress

    A Randomised Trial Of Normothermic Machine Perfusion Versus Static Cold Storage In Donation After Circulatory Death Renal Transplantation

    S. Hosgood1, C. Callaghan2, C. Wilson3, G. Oniscu4, B. Phillips5, L. Bates3, L. Smith6, M. L. Nicholson7

    1Surgery, University of Cambridge, Cambridge, United Kingdom, 2Transplant, Guys & St Thomas's, London, United Kingdom, 3Transplant, Freeman Hospital, Newcastle, United Kingdom, 4Edinburgh Royal Infirmary, Edinburgh, United Kingdom, 5Transplant, Guy's & St Thomas's, London, United Kingdom, 6NHSBT, NHSBT, Bristol, United Kingdom, 7University of Cambridge, Cambridge, United Kingdom

    *Purpose: Kidneys from donation after circulatory death (DCD) donors are more susceptible to cold storage injury and have a high risk of delayed graft function…
  • 2022 American Transplant Congress

    Lucas Device Assisted Uncontrolled Dcd Kidney Transplantation – A Feasible but Underutilized Option in the United States

    S. Nagaraju, S. Vaishnav, R. Savilla, M. Moore, J. B. Africa

    Renal Transplant, Charleston Area Medical Center, Charleston, WV

    *Purpose: Uncontrolled DCD (uDCD) procurement involves either normo-thermic or hypothermic regional perfusion to reduce ischemic injury. We report a series of successful kidney transplant utilizing…
  • 2022 American Transplant Congress

    Axl and MerTK Regulate the Activation of Liver Ischemia Reperfusion Injury by Upregulating Il-13 in Kupffer Cells

    J. Zhang1, M. Ni1, H. Zhang1, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, J. Jin3, Y. Zhai1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 3Guilin Medical University, Guilin, China

    *Purpose: Ischemia reperfusion injury (IRI) remains an unresolved clinical problem. A sterile inflammatory response drives the disease pathogenesis. Although mechanisms of liver innate immune activation…
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