2022 American Transplant Congress
A Model for Medical Device Innovation in Transplantation: Using the Biodesign Process to Address the Impact of Warm Ischemic Injury
1University of California San Francisco, San Francisco, CA, 2Stanford University, Palo Alto, CA
*Purpose: The impact of warming during second warm-ischemia (anastomosis) of kidney transplantation has been increasingly recognized in the literature. The outsized effect on delayed graft…2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…2022 American Transplant Congress
Deletion of AIF-1 Promotes Kidney Reparative Macrophages and Prevents Fibrosis
Duke University School of Medicine, Durham, NC
*Purpose: A major etiology contributing to poor allograft survival is the inevitable ischemic insult it incurs during transplantation. Macrophages are key players in ischemia-reperfusion injury,…2022 American Transplant Congress
Early Outcomes for Liver Transplant with Thoracoabdominal Normothermic Regional Perfusion for Donation After Circulatory Death: A Multi-Center Experience
*Purpose: We evaluated early outcomes of liver transplant after thoracoabdominal normothermic regional perfusion (TA-NRP) for controlled donation after circulatory death (cDCD) donors.*Methods: We identified liver…2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Are Critical Pro-Inflammatory Effector Cells in a Fatty Liver Mouse Model of Ischemia-Reperfusion Injury
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine…2022 American Transplant Congress
Complex Donor Transfer and Organ Procurement Organization Collaboration to Reduce Ischemia Time in Combined Face and Bilateral Hand Transplant
*Purpose: We present a complex donor transfer protocol that places the donor at the recipient hospital prior to allograft procurement in order to reduce ischemia…2022 American Transplant Congress
Perfusate Cell-Free DNA Content is a Potential Marker of Cellular Injury During Hypothermic Machine Perfusion of Porcine Kidneys Subject to Prolonged Warm Ischemia
1University of Florida, Gainesville, FL, 2University of Oklahoma, Oklahoma City, OK
*Purpose: Despite the potential benefits and expanding use of advanced dynamic perfusion systems in clinical practice, to date there is no robust and non-invasive method…2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…2022 American Transplant Congress
Impact of Recipient Warm Ischemic Time on Outcomes Associated with High KDPI and DCD Donor Kidneys: Cold Ischemic Time Remains Paramount
Department of Surgery, Atrium Health Wake Forest Baptist, Winston Salem, NC
*Purpose: Previously we demonstrated that cold ischemic time (CIT) beyond 24 hours was an important risk predictor of early graft loss (EGL) and primary non-function…2022 American Transplant Congress
Addressing the Organ Shortage, Improving Transplant Longevity, and Enabling Minimally Invasive Kidney Transplantation: Development of an Intraoperative Kidney Anastomosis Facilitation and Regelation Device
*Purpose: Second warm ischemia time (SWIT) of a renal allograft during anastomosis increases rates of delayed graft function and premature graft failure. In the setting…
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