Articles tagged "Vascular disease"

2021 American Transplant Congress
Impact of Statin Intensity on the Incidence of Vascular Events and Graft Survival in Heart Transplant Recipients
E. Kim¹, I. Booth², R. Madathil³, B. Ravichandran¹, M. Demehin², M. Plazak²
¹University of Maryland School of Pharmacy, Baltimore, MD, ²Pharmacy, University of Maryland Medical Center, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD
*Purpose: Cardiac allograft vasculopathy (CAV) limits long-term graft survival of heart transplant (HT) recipients. In addition to decreased synthesis of cholesterol, statins also demonstrate immunomodulatory…
2021 American Transplant Congress
Angiotensin II Type-1 Receptor Antibodies are Associated with Inferior Renal Allograft Survival
P. Martin, E. Santos, N. Gunby, M. Willicombe
Renal Department, Imperial College Healthcare NHS Trust, London, United Kingdom
*Purpose: AT1R-antibodies have been implicated in antibody-mediated vascular rejection in the absence of detectable HLA donor specific antibody (DSA), in addition to cardiovascular diseases. Transplant…
2021 American Transplant Congress
Coronary Computed Tomography Angiography for Pre-Liver Transplant Cardiovascular Risk Assessment: A Single Center Experience
J. Rice¹, T. Genders², D. Groves², J. R. Burton¹, J. Moloo², R. Quaife², D. Vargas³, M. Kriss¹
¹Division of Gastroenterology and Hepatology, University of Colorado, Aurora, CO, ²Division of Cardiology, University of Colorado, Aurora, CO, ³Division of Radiology, University of Colorado, Aurora, CO
*Purpose: Coronary computed tomography angiography (CCTA) is an established non-invasive imaging modality for diagnosing coronary artery disease (CAD), though its use for cardiovascular disease (CVD)…
2021 American Transplant Congress
Belatacept Conversion in Proteinuric Renal Transplant Recipients: An Interventional Multi-Center Trial
O. Efe¹, A. Al Jurdi¹, D. Wojciechowski², K. Safa¹, H. Gilligan¹, A. Chandraker³, J. Azzi³, A. Weins³, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²UT Southwestern Medical Center, Dallas, TX, ³Brigham and Women’s Hospital, Boston, MA
*Purpose: Proteinuria develops in about 30% of kidney transplant recipients and is a strong predictor of graft loss. ACEis/ARBs can reduce proteinuria but are frequently…
2020 American Transplant Congress
Age-Enhanced Transplant Vasculopathy Associates with Impaired Vascular Mitophagy
M. Blin¹, D. Tyrrell¹, S. Wood¹, D. Farris¹, S. G. Tullius², D. R. Goldstein¹
¹Micro and Immunology/Internal Medicine, University of Michigan, Ann Arbor, MI, ²Transplant Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor aging leads to increased chronic allograft vasculopathy (CAV) for unclear reasons. Here, we investigated whether impaired alterations in mitophagy, a mechanism to remove…
2020 American Transplant Congress
Glomerular Filtration Rate Based on Cystatin C Provides the Best Prediction of Cardiovascular Events and Mortality Compared to Measured GFR and Creatinine Based GFR in Kidney Transplant Recipients
L. Galapia¹, J. Lieske², A. Rule², H. Amer², N. Zhang¹, D. Butterfield¹, M. Keddis¹
¹Mayo Clinic, Scottsdale, AZ, ²Mayo Clinic, Rochester, MN
*Purpose: GFR estimated by cystatin C (CysC) is a better predictor of cardiovascular (CV) events and mortality compared to eGFR by creatinine (Cr) in native…
2020 American Transplant Congress
Retinal Vein Occlusion Incidence in Kidney Transplant Recipients in South Korea: A Long-Term Population-Based Study
J. Lee¹, S. Park¹, J. Kim¹, M. Yu², S. Baek³, K. Han⁴, D. Kim¹, K. Joo¹, Y. Kim¹, H. Lee¹, Y. Kim¹
¹Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ³Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea, Republic of, ⁴Medical Statistics, College of Medicine, Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: The risk of retinal vein occlusion(RVO) is known to increase in patients with chronic kidney disease, especially end-stage renal disease (ESRD). However, little is…
2020 American Transplant Congress
Determinants of Cardiovascular Benefit Observed in a Population with a Functioning Renal Transplant versus Patients Undergoing Chronic Dialysis
J. Sleiman, C. Castellaro, G. Laham, M. Schiavone, M. Biain, L. Brukman, G. Soler Pujol, C. Diaz
Nephrology, CEMIC, Caba, Argentina
*Purpose: Patients (pts) with end stage renal disease have a high morbidity and mortality rate, mostly due to cardiovascular events (CV). Transplantation (Tx) improves survival…
2020 American Transplant Congress
Standardization of Pre-Transplant Cardiac Testing in Kidney Transplant Recipients is Associated with Lower Post-Transplant Cardiac Events
I. Genev¹, A. Desai², R. Garcia-Roca³, S. Shah⁴, J. Lopez⁴, V. Mathew⁴, J. Yoo¹, S. Akkina¹
¹Department of Medicine, Loyola University Medical Center, Maywood, IL, ²Department of Medicine, Division of Transplant Nephrology, Loyola University Medical Center, Maywood, IL, ³Department of Surgery, Loyola University Medical Center, Maywood, IL, ⁴Department of Medicine, Division of Cardiology, Loyola University Medical Center, Maywood, IL
*Purpose: Cardiovascular disease is the leading cause of mortality after kidney transplantation and optimal approaches to pre-transplant cardiac testing are not well defined. We applied…
2020 American Transplant Congress
Assessment of Coronary Allograft Vasculopathy by Intravascular Ultrasound 6 Weeks and One Year after Heart Transplantation: A Single Center Study
A. Alam, E. Dib, H. Zafar, J. Felius, S. Hall, S. Joseph
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: Coronary allograft vasculopathy (CAV) continues to be a common cause of morbidity and mortality in heart transplant recipients. Little is known about the timing…