ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tumor recurrence"

  • 2019 American Transplant Congress

    Sustained Biologic Response To Neoadjuvant Therapy Predicts Excellent Liver Transplant Outcomes For Locally Advanced Intrahepatic Cholangiocarcinoma

    K. E. Lunsford1, M. Javle2, K. Heyne3, R. A. Ali2, C. M. Mobley1, A. Saharia1, D. W. Victor1, M. J. Hobeika1, A. Kasab2, R. S. McFadden1, T. A. Aloia2, X. C. Li1, H. P. Monsour1, A. O. Gaber1, A. O. Gaber1, J. Vauthey2, R. M. Ghobrial1

    1J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX, 2The University of Texas MD Anderson Cancer Center, Houston, TX, 3Department of Oncology, Houston Methodist Hospital, Houston, TX

    *Purpose: Intrahepatic cholangiocarcinoma (iCCA) is a contraindication for liver transplant (LT), but prior studies limited evaluation to incidental iCCA. We recently reported significant improvement in…
  • 2019 American Transplant Congress

    Outcomes of Liver Transplantation for Mixed Hepatocellular-Cholangiocarcioma

    M. Najjar1, K. Bruestle1, P. Jiang1, S. Robbins-Juarez1, R. Hwang1, A. Mathur1, E. C. Verna1, A. Griesemer1, B. Samstein1, T. Kato1, Y. M. Saenger1, K. J. Halazun2, J. C. Emond1

    1Columbia University Medical Center, New York, NY, 2Weill Cornell Medicine, New York, NY

    *Purpose: Mixed hepatocholangiocarcinomas (HCC-CCA) are rare tumors with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) differentiations. They are usually associated with a worse prognosis than…
  • 2019 American Transplant Congress

    mTOR Inhibitors Enhance Antitumor Activity of Liver Resident NK Cells

    J. Saparbay, Y. Tanaka, A. Seidakhmetov, H. Ohdan

    Gastroenterology and transplant Surgery, Hiroshima University, Hiroshima, Japan

    *Purpose: The immunosuppressive regimen currently used after organ transplantation reduces adaptive components. Therefore, the innate immune cells play pivotal roles in immune surveillance and defense…
  • 2019 American Transplant Congress

    Tumor Necrosis as a Result to Pre-Transplant Bridging Treatment for Hepatocellular Carcinoma and Its Effect on Post-Transplant Outcome

    S. Radunz1, A. Kirschner1, J. M. Theysohn2, C. Schotten3, T. Benkö1

    1General, Visceral and Transplant Surgery, University Hospital Essen, Essen, Germany, 2Diagnostic and Interventional Radiology and Neurradiology, University Hospital Essen, Essen, Germany, 3Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany

    *Purpose: As a bridge to liver transplantation, locoregional treatments are commonly employed in hepatocellular carcinoma (HCC) patients to prevent tumor progression during waiting time. Objective…
  • 2019 American Transplant Congress

    Early Everolimus Conversion For Renal Protection In Liver Transplantation: The Sooner The Better?

    M. Tomeczkowicz, N. Sulejmani, A. Jantz, B. Summers, T. Larson, R. Salgia

    Henry Ford Health System, Detroit, MI

    *Purpose: Calcineurin inhibitors (CNI) are the mainstay of immunosuppressive therapy in transplantation; however, a major side effect limiting CNI use is nephrotoxicity. Mammalian target of…
  • 2019 American Transplant Congress

    Renal Cell Carcinoma in Dialysis Patients: Criteria for Transplant Wait List Inclusion

    D. B. Laskar1, J. Zeng1, S. Sharma2, M. T. Smith Jr3, A. D. Nicastri1, D. Levitan4, R. Maglantay1, D. John3, S. R. Gottesman1

    1Pathology, SUNY Downstate Medical Center, Brooklyn, NY, 2Transplant Surgery, NYP/Columbia University Medical Center, New York, NY, 3Surgery, SUNY Downstate Medical Center, Brooklyn, NY, 4Pathology & Laboratory Medicine, NYP/Weill Cornell Medical Center, New York, NY

    *Purpose: End-stage renal disease (ESRD) patients on long-term hemodialysis have a higher incidence of renal cell carcinoma (RCC) in their native kidneys than the general…
  • 2018 American Transplant Congress

    Predictive Value of mRECIST in HCC Response to the Neoadjuvant Locoregional Therapies and Prognosis Affected by the Peak AFP Level before Liver Transplantation

    M. Xu,1 T. Fraum,2 S. Garcia-Aroz,1 N. Vachharajani,1 N. Saad,3 K. Fowler,2 Y. Lin,1 W. Chapman.1

    1Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; 2Department of Radiology, Washington University School of Medicine, St. Louis, MO; 3Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY.

    PURPOSE: The modified response evaluation criteria in solid tumors (mRECIST) has been used to assess the response of hepatocellular carcinoma (HCC) to locoregional therapy (LRT)…
  • 2018 American Transplant Congress

    Malignancies in Kidney Transplant Recipients: A Long-Term Observational Study

    D. Khadzhynov, F. Halleck, F. Froehlich, L. Lehner, E. Schrezenmeyer, K. Budde, O. Staeck.

    Nephrology and Internal Intensive Care, Charite Universitaetsmedizin Berlin, Berlin, Germany.

    Background: Previous studies have shown increased incidence of malignancies in patients after kidney transplantation. However, most of the existing data on post-transplant malignancies is limited…
  • 2018 American Transplant Congress

    A Novel Nomogram-Based Approach for Defining the Effect of Transplantation on Cancer Recurrence Risk

    N. Ejaz,1 R. Alloway,1 F. Paterno,1 A. Singhal,1 X. Ji,2 M. Kattan,2 E. Woodle.1

    1U of Cincinnati, Cincinnati; 2Cleveland Clinic, Cleveland.

    The effect of transplantation on renal cell cancer (RCC) recurrence risk has not yet been precisely defined. Validated nomograms for predicting RCC recurrence risk (viz,…
  • 2018 American Transplant Congress

    Liver Transplantation for Patients with Hepatocellular Carcinoma Presenting beyond Milan Criteria: Analysis of 789 Patients from the US Multicenter HCC Transplant Consortium

    V. Agopian, United States Multicenter HCC Transplant Consortium.

    UCLA, LA.

    Objective: OPTN has recently approved MELD prioritization for HCC patients beyond Milan Criteria (MC) who are downstaged (DS) with locoregional therapy (LRT) prior to liver…
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