2020 American Transplant Congress
Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver
*Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…2020 American Transplant Congress
Analysis of the Mechanism of Liver-Resident NK Cells Activity via the Aryl Hydrocarbon Receptor
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Tumor recurrence is the main limitation of liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). We previously reported an adoptive immunotherapy approach that…2020 American Transplant Congress
Modulating ITK Signaling Facilitate Allogeneic Skin Engraftment and Clear LCMV Viruses by Regulating IRF-4, JAK STAT and Eomes Expression
*Purpose:Solid organ transplantation is a life-saving procedure to treat end-stage organ failure. However, transplantation of organs between genetically distinct individuals results in acute graft rejection…2020 American Transplant Congress
A Single-Cell Transcriptome Atlas of 15 Adult Human Organs
*Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…2019 American Transplant Congress
Platelets Stimulate Liver Regeneration in a 30% Partial Liver Transplantation Model in Rat
University of Tsukuba, Tsukuba, Japan
*Purpose: Thirty years after the first living donor liver transplantation (LDLT), this technique has been widely recognized as the golden standard in treatment of end-stage…2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…2019 American Transplant Congress
How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…2019 American Transplant Congress
Obesity Induced IL-18 Production Impairs FOXP3+ Treg Function and Increases Risk of Primary Graft Dysfunction in Lung Transplant Recipients
*Purpose: Lung transplantation is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD)…2019 American Transplant Congress
Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
American Transplant Congress abstracts