ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Toxocity"

  • 2019 American Transplant Congress

    Combination of Extended-Release Tacrolimus Plus Everolimus Once Daily in De Novo Kidney Transplant Recipients: ER-Tac vs LCPT

    G. Spagnoletti, M. P. Salerno, F. De Gennaro, J. Romagnoli, F. Citterio

    Surgery, Renal Transplant Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    *Purpose: Combination of Everolimus (EVR) with Tacrolimus (Tac) permits reduced calcineurin inhibitors exposure and, recently, has been demonstrated safe and effective. Two different once-daily Tacrolimus…
  • 2019 American Transplant Congress

    Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition

    H. ZHOU, Q. Wang, R. Liu, S. Zhou, F. Cheng, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…
  • 2019 American Transplant Congress

    CHOP Deficiency Attenuated Acute Liver Injury by Promoting Macrophage M2 Polarization via ATG5-Mediated Autophagy Activation

    H. Zhou, R. Liu, Q. Wang, C. Shi, F. Cheng, X. Wang, L. Lu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Critical roles of CCAAT-Enhancer-Binding Protein Homologous Protein (CHOP) have been found in mediating acute liver injury. The aim of this study is to determine…
  • 2019 American Transplant Congress

    Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation

    S. Tajima1, R. Fu2, M. Fukuda2, K. Suetsugu2, Y. Okabe3, S. Masuda1

    1Pharmacy, Kyushu University Hospital, Fukuoka, Japan, 2Clinical Pharmacology and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, 3Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    *Purpose: Biopsy proven acute rejection without clinical symptoms such as subclinical rejection (SCR) is supposed to associate graft loss in the long term post kidney…
  • 2019 American Transplant Congress

    The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury

    J. Zheng, F. Xue

    Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China

    *Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…
  • 2019 American Transplant Congress

    Utilization of LCP-Tacrolimus (ENVARSUS XR) in Simultaneous Pancreas and Kidney (SPK) Transplant Recipients

    J. Torabi, A. Campbell, E. Akalin, M. Ajaimy, Y. Azzi, C. Pynadath, L. Liriano-Ward, J. P. Rocca, J. A. Graham

    Montefiore Medical Center, Bronx, NY

    *Purpose: The use of extended release tacrolimus (LCPT) allows for slow release of drug and once-daily dosing in transplant recipients. The improved bioavailability and decreased…
  • 2018 American Transplant Congress

    Gut Microbiota, Mycophenolate Mofetil, and Post-Transplant Diarrhea in Kidney Transplant Recipients

    J. Lee,1 M. Magruder,1 L. Zhang,1 D. Dadhania,1 M. Satlin,1 L. Westblade,1 A. Robertson,1 Y. Taur,2 L. Ling,2 E. Pamer,2 M. Suthanthiran.1

    1Weill Cornell Medicine, New York, NY; 2Memorial Sloan Kettering, New York, NY.

    INTRODUCTION. The etiology of post-transplant diarrhea is often unknown and attributed to mycophenolate mofetil dosage.METHODS. We recruited 71 kidney transplant recipients for serial collection of…
  • 2018 American Transplant Congress

    Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1

    N. Knops,1 Y. Ramazani,2 B. Van den Heuvel,2 R. Goldschmeding,3 T. Nguyen,3 E. Levtchenko,1 D. Kuypers.4

    1Paediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Laboratory of Paediatrics, KU Leuven, Leuven, Belgium; 3Pathology, University Medical Center Utrecht, Utrecht, Netherlands; 4Nephrology, University Hospitals Leuven, Leuven, Belgium.

    AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…
  • 2017 American Transplant Congress

    Adjuvant Chemotherapy with Gemcitabine Plus Cisplatin for Kidney Transplant Patients with Transitional Cell Carcinoma.

    Z. Wang, J. Lin, Y. Zhu, J. Zhang, J. Xiao, Y. Guo, Y. Tian.

    Urology, Beijing Friendship Hospital, Beijing, China

    Background: The purpose of this study was to evaluate the effects and safety of adjuvant chemotherapy with gemcitabine plus cisplatin in kidney transplant patients with…
  • 2017 American Transplant Congress

    Belatacept Conversion for Calcineurin Inhibitor (CNI) Toxicity: Our First 100 Patients.

    R. Crew, S. Patel, A. Pai, I. Batal, H. Fernandez.

    Columbia University, New York

    Intro: CNIs improve kidney transplant (KT) survival, but have significant toxicities, including graft dysfunction (GD), neurotoxicity (NT), or thrombotic microangiopathy (TMA). Belatacept is an alternative…
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