2019 American Transplant Congress
Hyperglycemia Aggravates Acute Liver Injury by Promoting Macrophage NLRP3 Activation via AMPK/mTOR-Dependent Autophagy Inhibition
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The detrimental effects of diabetes mellitus/hyperglycemia include an increase in the oxidative stress response and an enhanced inflammatory response. Despite an increased understanding of…2019 American Transplant Congress
CHOP Deficiency Attenuated Acute Liver Injury by Promoting Macrophage M2 Polarization via ATG5-Mediated Autophagy Activation
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Critical roles of CCAAT-Enhancer-Binding Protein Homologous Protein (CHOP) have been found in mediating acute liver injury. The aim of this study is to determine…2019 American Transplant Congress
Urinary Microtubule-Associated Protein Light Chain3 and Neutrophil Gelatinase-Associated Lipocalin, as Potential Noninvasive Biomarkers for Subclinical Rejection at 3 Months after Kidney Transplantation
*Purpose: Biopsy proven acute rejection without clinical symptoms such as subclinical rejection (SCR) is supposed to associate graft loss in the long term post kidney…2019 American Transplant Congress
The lncRNA-mRNA Co-Expression Analysis in Acetaminophen-Induced Liver Injury
*Purpose: Acetaminophen (APAP) could cause liver injury, or even acute liver failure, accounting for approximately one-half of all cases in developed countries. Once acute liver…2019 American Transplant Congress
Utilization of LCP-Tacrolimus (ENVARSUS XR) in Simultaneous Pancreas and Kidney (SPK) Transplant Recipients
Montefiore Medical Center, Bronx, NY
*Purpose: The use of extended release tacrolimus (LCPT) allows for slow release of drug and once-daily dosing in transplant recipients. The improved bioavailability and decreased…2019 American Transplant Congress
Mitochondrial Dysfunction and Metabolic Reprogramming: Critical Features of Cyclosporine A Nephrotoxicity
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Calcineurin inhibitors (CNIs) are potent immunosuppressants but over time contribute to allograft fibrosis. Clinical efforts to minimize or avoid CNI have not been uniformly…2018 American Transplant Congress
Gut Microbiota, Mycophenolate Mofetil, and Post-Transplant Diarrhea in Kidney Transplant Recipients
1Weill Cornell Medicine, New York, NY; 2Memorial Sloan Kettering, New York, NY.
INTRODUCTION. The etiology of post-transplant diarrhea is often unknown and attributed to mycophenolate mofetil dosage.METHODS. We recruited 71 kidney transplant recipients for serial collection of…2018 American Transplant Congress
Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1
AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…2017 American Transplant Congress
Belatacept Conversion for Calcineurin Inhibitor (CNI) Toxicity: Our First 100 Patients.
Intro: CNIs improve kidney transplant (KT) survival, but have significant toxicities, including graft dysfunction (GD), neurotoxicity (NT), or thrombotic microangiopathy (TMA). Belatacept is an alternative…2017 American Transplant Congress
Adjuvant Chemotherapy with Gemcitabine Plus Cisplatin for Kidney Transplant Patients with Transitional Cell Carcinoma.
Urology, Beijing Friendship Hospital, Beijing, China
Background: The purpose of this study was to evaluate the effects and safety of adjuvant chemotherapy with gemcitabine plus cisplatin in kidney transplant patients with…
American Transplant Congress abstracts