ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Toxocity"

  • 2022 American Transplant Congress

    Poor Tolerability of CFTR Modulator Therapy in Lung Transplant Recipients

    C. Doligalski, C. McKinzie, A. Yang, R. Coakley

    UNC Health, Chapel Hill, NC

    *Purpose: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations, however…
  • 2022 American Transplant Congress

    Early Tacrolimus Exposure is Associated with BK-Viremia in Kidney Transplant Recipients

    S. Meziyerh, A. L. van Rijn, D. van der Helm, P. J. van der Boog, T. van Gelder, A. C. Kroes, J. W. de Fijter, D. J. Moes, J. I. Rotmans, M. C. Feltkamp, A. P. de Vries

    LUMC, Leiden, Netherlands

    *Purpose: There is scant evidence to what extent maintenance immunosuppression is quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood…
  • 2022 American Transplant Congress

    Transplant Graft TMA Injury Post COVID-19 Vaccination

    O. Sogbein, A. Rizvi, M. Mujtaba, S. Hussain

    Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Vaccination against SARS-CoV-2 is essential. Complicating this effort are reports of a suboptimal response to the SARS-CoV-2 spike protein in patients on immunosuppressive medications…
  • 2021 American Transplant Congress

    Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques

    S. Perrin1, A. Gill2, C. Gill2, F. Vieira2, K. Thompson2

    1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA

    *Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…
  • 2021 American Transplant Congress

    A Case-Match Cohort Comparison of the Safety and Efficacy of Basiliximab for Immunosuppression Holiday in Lung Transplant Patients

    M. M. Eiting1, J. E. Clark1, T. L. Astor2, J. Palafox2, C. Rogers Marks1, G. Waldman1

    1Pharmacy, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: Post-transplant complications related to calcineurin inhibitors (CNI) maintenance immunosuppression (MI) may require interim alternative therapies. The goal of this study is to evaluate the…
  • 2020 American Transplant Congress

    Quantifiable Loss of Insulin Secretory Granules in Delayed Endocrine Pancreas Graft Function in Comparison to Controls

    C. B. Drachenberg1, J. C. Papadimitriou1, J. R. Scalea2, A. Haririan3, R. Ugarte3, S. Niederhaus2, J. Bromberg2

    1Pathology, University of Maryland, Baltimore, MD, 2Surgery, University of Maryland, Baltimore, MD, 3Medicine, University of Maryland, Baltimore, MD

    *Purpose: Approximately 1/3 of pancreas transplant fail to gain glycemic control in the first days/weeks posttransplantation, requiring exogenous insulin administration. Delayed endocrine pancreas graft function…
  • 2020 American Transplant Congress

    Largest Experience of Safety, and Efficacy of Patiromer in Solid Organ Transplants (SOT)

    P. Singh1, H. Winters2, T. E. Pesavento1, K. Schnelle2

    1Transplant Nephrology, Ohio State University, Columbus, OH, 2Transplant Pharmacy, Ohio State University, Columbus, OH

    *Purpose: Hyperkalemia, a potentially life‐threatening electrolyte abnormality, is commonly seen SOT. The predisposing factors are renal-dysfunction, and medications (CNI, TMP-SMX, ACEI, and ARBs). Patiromer, a…
  • 2020 American Transplant Congress

    Efficacy and Safety of Cytomegalovirus Antiviral Preventive Strategies in Kidney Transplant: A Systematic Literature Review

    A. Raval1, K. Kistler2, Y. Tang1, Y. Murata1, D. Snydman3

    1Merck & Co., Inc., Kenilworth, NJ, 2Evidera, Inc., Waltham, MA, 3Tufts Medical Center, Boston, MA

    *Purpose: Cytomegalovirus (CMV) is associated with significant mortality and morbidity in kidney transplant recipients (KTRs). Various CMV anti-viral (AV) preventive strategies have been utilized in…
  • 2020 American Transplant Congress

    Characteristics and Outcomes of Acetaminophen Overdose Related Hospitalizations Requiring Liver Transplant

    A. Khan1, N. Saleem2, M. Bilal3, R. Tariq4, S. Singh5

    1West Virginia University-Charleston division, Charleston, WV, 2University of Tennessee Health Science Center, Memphis, TN, 3Beth Israel Deaconess Medical Center, Boston, MA, 4Rochester General Hospital, Rochester, NY, 5Charleston Area Medical Center, Charleston, WV

    *Purpose: Acetaminophen overdose (AO) may lead to severe liver damage requiring an urgent liver transplant (LT). The data on hospital-related outcomes in patients with AO…
  • 2019 American Transplant Congress

    Combination of Extended-Release Tacrolimus Plus Everolimus Once Daily in De Novo Kidney Transplant Recipients: ER-Tac vs LCPT

    G. Spagnoletti, M. P. Salerno, F. De Gennaro, J. Romagnoli, F. Citterio

    Surgery, Renal Transplant Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy

    *Purpose: Combination of Everolimus (EVR) with Tacrolimus (Tac) permits reduced calcineurin inhibitors exposure and, recently, has been demonstrated safe and effective. Two different once-daily Tacrolimus…
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