2022 American Transplant Congress
Poor Tolerability of CFTR Modulator Therapy in Lung Transplant Recipients
*Purpose: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a highly effective therapy for cystic fibrosis (CF) with potential benefits in lung transplant recipients (LTRs) for extrapulmonary CF manifestations, however…2022 American Transplant Congress
Early Tacrolimus Exposure is Associated with BK-Viremia in Kidney Transplant Recipients
*Purpose: There is scant evidence to what extent maintenance immunosuppression is quantitatively associated with BK viremia. We investigated the association between tacrolimus (tac) whole blood…2022 American Transplant Congress
Transplant Graft TMA Injury Post COVID-19 Vaccination
Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Vaccination against SARS-CoV-2 is essential. Complicating this effort are reports of a suboptimal response to the SARS-CoV-2 spike protein in patients on immunosuppressive medications…2021 American Transplant Congress
Pharmacokinetic and Toxicity Studies of an Anti CD40L Antibody, At-1501 in Rhesus Macaques
1Novus Therapeutics, Irvine, CA, 2ALS Therapy Development Institute, Cambridge, MA
*Purpose: CD40L is a costimulatory receptor for CD40 found on T helper cells. Binding of CD40L on T cells to CD40 on antigen presenting cells…2021 American Transplant Congress
A Case-Match Cohort Comparison of the Safety and Efficacy of Basiliximab for Immunosuppression Holiday in Lung Transplant Patients
1Pharmacy, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Post-transplant complications related to calcineurin inhibitors (CNI) maintenance immunosuppression (MI) may require interim alternative therapies. The goal of this study is to evaluate the…2020 American Transplant Congress
Efficacy and Safety of Cytomegalovirus Antiviral Preventive Strategies in Kidney Transplant: A Systematic Literature Review
1Merck & Co., Inc., Kenilworth, NJ, 2Evidera, Inc., Waltham, MA, 3Tufts Medical Center, Boston, MA
*Purpose: Cytomegalovirus (CMV) is associated with significant mortality and morbidity in kidney transplant recipients (KTRs). Various CMV anti-viral (AV) preventive strategies have been utilized in…2020 American Transplant Congress
Characteristics and Outcomes of Acetaminophen Overdose Related Hospitalizations Requiring Liver Transplant
*Purpose: Acetaminophen overdose (AO) may lead to severe liver damage requiring an urgent liver transplant (LT). The data on hospital-related outcomes in patients with AO…2020 American Transplant Congress
Quantifiable Loss of Insulin Secretory Granules in Delayed Endocrine Pancreas Graft Function in Comparison to Controls
*Purpose: Approximately 1/3 of pancreas transplant fail to gain glycemic control in the first days/weeks posttransplantation, requiring exogenous insulin administration. Delayed endocrine pancreas graft function…2020 American Transplant Congress
Largest Experience of Safety, and Efficacy of Patiromer in Solid Organ Transplants (SOT)
*Purpose: Hyperkalemia, a potentially life‐threatening electrolyte abnormality, is commonly seen SOT. The predisposing factors are renal-dysfunction, and medications (CNI, TMP-SMX, ACEI, and ARBs). Patiromer, a…2019 American Transplant Congress
Mitochondrial Dysfunction and Metabolic Reprogramming: Critical Features of Cyclosporine A Nephrotoxicity
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Calcineurin inhibitors (CNIs) are potent immunosuppressants but over time contribute to allograft fibrosis. Clinical efforts to minimize or avoid CNI have not been uniformly…
American Transplant Congress abstracts