2020 American Transplant Congress
Life-Supporting Pig Thymus Plus Kidney Transplantation Leads to Generation of New Baboon T-Cells and Swine-Specific Hyporesponsiveness
*Purpose: We have achieved greater than 6-month survivals in baboons that received vascularized thymus plus kidney xenotransplants (VT+K XTx). We assessed the thymic function and…2019 American Transplant Congress
Generation of Thymic Epithelial Cells from Induced Pluripotent Stem Cells to Prolong Allograft Survival
Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
*Purpose: Pluripotent stem cell (PSC) is a potential source of generating functional therapeutic cells for transplantation. Embryonic stem cells are of absolutely allogeneic origin. Induced…2019 American Transplant Congress
Generation of Human/Pig Hybrid Thymus to Achieve Immune Tolerance to Pig Antigens with Optimal Immune Function
Columbia University, New York, NY
*Purpose: Thymus transplantation is a promising approach to induce T-cell tolerance for xenotransplantation. We have previously shown that humanized mice generated with human hematopoietic stem…2019 American Transplant Congress
TCR Transgenes to Understand Human Xenotolerance Induction
Columbia Center for Translational Immunology, New York, NY
*Purpose: Swine thymus transplantation is a promising approach to clinical tolerance for pig-to-human xenotransplantation. In humanized mice, a swine thymus graft supports de novo selection…2018 American Transplant Congress
Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation
Background: Allogeneic thymus has been investigated to achieve donor-specific tolerance in organ transplantation. Often thymus co-transplantation induces long-term graft survival in immunodeficient and total lymphoid…2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…2015 American Transplant Congress
Chimeric Thymus Versus Antigen Presenting Thymus for the Induction of Tolerance: Donor DCs in Vascularized Thymus Grafts Play an Essential Role in the Induction of Tolerance
We have demonstrated that thymus plays an important role in transplantation tolerance in MHC inbred large animals. We have established a technique of isolated vascularized…2015 American Transplant Congress
Heart En Bloc Thymus Transplantation Permits Long-Term, Acute Rejection-Free Cardiac Allograft Survival in Nonhuman Primates (NHPs)
BACKGROUNDThe role of vascularized thymus on tolerance induction has been well studied in swine recipients of kidney allografts, but not in NHP recipients of heart…2015 American Transplant Congress
Thymic Transplantation to Determine Mechanisms of Thymic Involution: Insulin-Like Growth Factor 1 Receptor and Forkhead Box Protein N1 in the Thymus Play a Role in Maintaining the Juvenile Thymus
Thymic involution has long been associated with age-related changes of the immune system, although the cause remains unclear. We have extensively studied the role of…
American Transplant Congress abstracts