Articles tagged "Thymic tolerance"

2019 American Transplant Congress
Generation of Human/Pig Hybrid Thymus to Achieve Immune Tolerance to Pig Antigens with Optimal Immune Function
M. Khosravi Maharlooei, H. Li, M. Holzl, A. Vecchione, A. Misra, A. Ruiz, R. Madley, G. Nauman, N. Danzl, G. Zhao, K. Yamada, M. Sykes
Columbia University, New York, NY
*Purpose: Thymus transplantation is a promising approach to induce T-cell tolerance for xenotransplantation. We have previously shown that humanized mice generated with human hematopoietic stem…
2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…
2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2016 American Transplant Congress
Engineering a “Hybrid Thymus” to Promote Transplant Tolerance.
S. AlFadil,¹ M.-J. Kim,² M. Iglesias Lozano,¹ B. Oh,¹ W. Lee,¹ G. Brandacher,¹ T. Serworld,² G. Raimondi.¹
¹Plastic & Recnstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD; ²Joslin Diabetes Center, Boston, MA.
Purpose: Targeting the process of central (thymic) selection of developing T lymphocytes is the key tolerogenic mechanism of bone marrow transplantation (BM-Tx)-based protocols for transplant…
2015 American Transplant Congress
Regulatory T Cells Expanded by Activated iNKT Cells Facilitate Migration of Donor Dendritic Cells Into the Recipient Thymus and Subsequent Establishment of Clonal Deletion
T. Hirai,¹ R. Shibahara,¹ S. Miyairi,¹ M. Ikemiyagi,¹ K. Omoto,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RINEK Center for IMS, Yokohama, Japan.
We previously reported that combination therapy using liposomal α-galactosylceramide (lipo-αGC) and anti-CD154 mAb could expand regulatory T cells (Tregs) in vivo through activation of the…
2015 American Transplant Congress
Chimeric Thymus Versus Antigen Presenting Thymus for the Induction of Tolerance: Donor DCs in Vascularized Thymus Grafts Play an Essential Role in the Induction of Tolerance
K. Yamada, M. Sekijima, A. Kawai, T. Tanabe, M. Tasaki, V. Villani, I. Hanekamp, A. Shimizu, D. Sachs.
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
We have demonstrated that thymus plays an important role in transplantation tolerance in MHC inbred large animals. We have established a technique of isolated vascularized…