Articles tagged "Stem cells"

2020 American Transplant Congress
Novel Mechanism of Immune Evasion by Human Neonatal Cardiac Progenitor Cells Recovers Ailing Myocardium in Rat Myocardial Infarct Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, L. Davidson, X. Fu, A. Shah, M. Abdullah, D. Li, S. Kaushal
Surgery, University of Maryland, Baltimore, MD
*Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal cardiac progenitor cells…
2020 American Transplant Congress
Immune Response Following Cardiac Progenitor Cells Transplantation in Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Wang, M. Yasir Arfat, X. Fu, S. Kaushal
Surgery, University of Maryland, Baltimore, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo…
2020 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model
S. Lee¹, J. Lee², H. Park², Y. Kim², S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
2020 American Transplant Congress
What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?
K. Rozenberg¹, L. Knijff¹, J. Sierra-Parraga², L. Lo Faro¹, M. Hoogduijn², C. Baan², J. Hunter¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
2020 American Transplant Congress
Potential to Regenerate Damaged Allografts
L. Brasile¹, B. Stubentisky²
¹Research and Development, Breonics Inc., Watervliet, NY, ²Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands
*Purpose: The chronic shortage of allografts has generated intense interest in the field of regenerative medicine. Given the limited regeneration that can be accomplished in…
2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Y. Zhang, M. Chen, W. Ju, T. Wang, Z. Chen, C. Huang, R. Xie, Q. Zhao, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…
2020 American Transplant Congress
Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique
S. Takaichi¹, T. Akagi², Y. Tomimaru¹, S. Kobayashi¹, Y. Iwagami¹, H. Akita¹, T. Noda¹, K. Gotoh¹, Y. Doki¹, M. Akashi², H. Eguchi¹
¹Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan, ²Building Block Science Joint Research Chair, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan
*Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…
2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
2020 American Transplant Congress
Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes
C. M. Darden¹, S. Vasu², K. Kumano¹, Y. Liu², P. Saravanan³, B. Naziruddin², M. Lawrence²
¹Institute of Biomedical Studies, Waco, TX, ²Baylor University Medical Ctr, Dallas, TX, ³Transplant Surgery Department, VCU, Richmond, VA
*Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…