ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2020 American Transplant Congress

    Construction of Three-Dimensional Vascularized Functional Beta-Cells Tissues Using a Layer-by-Layer Cell Coating Technique

    S. Takaichi1, T. Akagi2, Y. Tomimaru1, S. Kobayashi1, Y. Iwagami1, H. Akita1, T. Noda1, K. Gotoh1, Y. Doki1, M. Akashi2, H. Eguchi1

    1Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan, 2Building Block Science Joint Research Chair, Graduate School of Frontier Biosciences, Osaka University, Suita, Japan

    *Purpose: Regenerative therapy for type I Diabetes Mellitus has been expected to be a promising treatment. A subcutaneous site is an ideal candidate for stem…
  • 2020 American Transplant Congress

    Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression

    M. C. Poznansky1, D. Alagpulinsa1, J. Lei2, R. Pop3, D. Sobell4, M. Chapin1, S. Collins3, A. Veres3, H. Deng2, D. Melton3, J. Markmann2

    1Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, 2Transplant Surgery, Massachusetts General Hospital, Boston, MA, 3Harvard Stem Cell Institute, Harvard University, Cambridge, MA, 4Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA

    *Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
  • 2020 American Transplant Congress

    Building Kidneys from Stem Cells for Transplantation

    I. M. Rogers1, J. Whiteley2, T. Chow2, T. Bongolan2, L. Mazilescu3, P. Urbanellis3, S. Ganesh3, M. Selzner3

    1Physiology, University of Toronto, Toronto, ON, Canada, 2LTRI-Sinai Health System, Toronto, ON, Canada, 3MOTU, University Health Network, Toronto, ON, Canada

    *Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
  • 2020 American Transplant Congress

    Pancreatic Mesenchymal Stromal Cells (MSC) Contain a Subset of Islet Progenitor Cells Capable of Regenerating Islets and Reversing Diabetes

    C. M. Darden1, S. Vasu2, K. Kumano1, Y. Liu2, P. Saravanan3, B. Naziruddin2, M. Lawrence2

    1Institute of Biomedical Studies, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX, 3Transplant Surgery Department, VCU, Richmond, VA

    *Purpose: To identity islet precursor cells residing in pancreatic MSC culture preparations that contribute to islet regeneration and restoration of islet cell function in both…
  • 2020 American Transplant Congress

    Donor Mesenchymal Stem Cells in Combination with Co-Stimulation Blockade Prolong Allograft Survival

    A. J. Matar, B. P. Lovasik, S. C. Kim, C. A. Breeden, D. A. Faber, D. V. Mathews, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams

    Surgery and Transplantation, Emory University, Atlanta, GA

    *Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy and potential alternative to calcineurin inhibitors in solid organ transplantation. Despite recent advancements, CoB…
  • 2020 American Transplant Congress

    CD47/SIRPα Signaling Controls TLR4-Driven Inflammatory Response via Regulating the Akt-β-Catenin Axis in Mesenchymal Stem Cell (MSC)-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury

    M. Sheng, Y. Lin, C. Li, Y. Tian, D. Xu, Y. Zhan, A. J. Coito, D. G. Farmer, R. W. Busuttil, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA

    *Purpose: Innate immune-driven local inflammation induced by ischemia/reperfusion injury (IRI) causes hepatic dysfunction and failure following liver transplantation. Although mesenchymal stem cell (MSC)-based therapy has…
  • 2020 American Transplant Congress

    Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis

    Y. Jia, M. Xu, T. Zhu

    Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
  • 2020 American Transplant Congress

    Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation

    K. Rozenberg1, S. Lohmann2, M. Pool3, M. Eijken4, U. Møldrup5, B. Møller6, J. Sierra-Parraga7, M. Hoogduijn7, L. Lo Faro1, C. Moers3, J. Hunter1, A. Keller2, H. Leuvenink3, C. Baan7, R. Ploeg1, B. Jespersen2

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, 4Department of Renal Medicine, Aarhus University, Aarhus, Denmark, 5Department of Urology, Aarhus University, Aarhus, Denmark, 6Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, 7Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
  • 2020 American Transplant Congress

    microRNA-223 in MSCS-Derived Exosomes Protects Against Renal Ischemia/Reperfusion Injury Through Inhibiting Pyroptosis Pathway via Directly Targeting NLRP3

    C. Ding, W. Xue

    Department of Renal Transplantation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

    *Purpose: miR-223 is a well-studied miRNA that has been tested for abnormal expression in many diseases, and it has been found to play a regulatory…
  • 2020 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding

    Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
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