Articles tagged "Stem cells"

2021 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
S. K. Salgar¹, J. Weiss², C. Phillips², E. Malin², V. Gorantla³, J. Harding⁴
¹Clinical Investigation, United States Army, Tacoma, WA, ²Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, ³Surgery, Wake Forest University, Winston-Salem, NC, ⁴Neuroscience, Washington State Universisty, Pullman, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
2021 American Transplant Congress
Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model
E. K. Ludwig¹, N. Abraham², D. Sudan², A. Barbas², C. Schaaf¹, J. Freund¹, A. S. Stewart¹, B. Veerasammy¹, L. M. Gonzalez¹
¹North Carolina State University, Raleigh, NC, ²Duke University, Durham, NC
*Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
2021 American Transplant Congress
MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update
D. Kaufman¹, S. Akkina², M. Stegall³, J. Piper⁴, A. O. Gaber⁵, E. Marin⁶, S. Busque⁷, D. Alonso⁸, M. De Vera⁹, A. Shah¹⁰, A. Patel¹¹, K. Chavin¹², M. Laftavi¹³, S. Collette¹⁴, E. Stites¹⁵, M. Mai¹⁶, M. Cooper¹⁷, D. Brennan¹⁸
¹Surgery, UW, Madison, WI, ²Surgery, Loyola, Chicago, IL, ³Surgery, Mayo, Rochester, MN, ⁴Surgery, Inova, Fairfax, VA, ⁵Surgery, Houston Methodist, Houston, TX, ⁶Nephrology, Yale, New Haven, CT, ⁷Surgery, Stanford, San Francisco, CA, ⁸Surgery, Intermountain, Murray, UT, ⁹Surgery, Loma Linda, Loma Linda, CA, ¹⁰Surgery, TJU, Philadelphia, PA, ¹¹Nephrology, St. Barnabas, Livingston, NJ, ¹²Surgery, UHH, Cincinnati, OH, ¹³Surgery, Upstate, Syracuse, NY, ¹⁴Surgery, CIUSSS, Montreal, ON, Canada, ¹⁵Nephrology, UC Denver, Denver, CO, ¹⁶Nephrology, Mayo - FL, Jacksonville, FL, ¹⁷Surgery, Georgetown, Washington, DC, ¹⁸Medeor, San Francisco, CA
*Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…
2021 American Transplant Congress
CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury
D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke
Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA
*Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
R. Lathan, P. Mark, M. Clancy, R. Touyz
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
2021 American Transplant Congress
First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)
J. Lei¹, S. Collins², H. Deng¹, Z. Yang¹, A. Zhang¹, C. Peters¹, J. Zhang², K. Boulanger², M. Yu³, M. Rickels³, C. Liu³, R. Pop², A. Naji³, D. Melton², J. Markmann¹
¹Surgery, Mass General, Boston, MA, ²Harvard Stem Cell Institute, Harvard University, Boston, MA, ³Surgery, Upenn, Philadelphia, PA
*Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
2021 American Transplant Congress
Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC
F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner
Mayo Clinic, Rochester, MN
*Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
2021 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal¹, J. Galvin², J. Mathew¹, L. Gallon¹, D. Belshe¹, M. Gibson¹, K. Ravindra³, M. Horwitz³, S. Ildstad⁴
¹Northwestern University, Comprehensive Transplant Center, Chicago, IL, ²Northwestern University, Chicago, IL, ³Duke Medical Center, Durham, NC, ⁴University of Louisville, Llouisville, KY
*Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor renal…
2020 American Transplant Congress
Long-term Functional Survival of Human Stem Cell-Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky¹, D. Alagpulinsa¹, J. Lei², R. Pop³, D. Sobell⁴, M. Chapin¹, S. Collins³, A. Veres³, H. Deng², D. Melton³, J. Markmann²
¹Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestown Navy Yard, MA, ²Transplant Surgery, Massachusetts General Hospital, Boston, MA, ³Harvard Stem Cell Institute, Harvard University, Cambridge, MA, ⁴Vaccine and Immunotherapy Center, Massachusetts General Hospital, Boston, MA
*Purpose: Human pluripotent stem cell-derived islet-like cells (SC-islets) represent a practical source for beta-cell replacement to achieve a functional cure for type 1 diabetes. Long-term…
2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…