ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2021 American Transplant Congress

    CD47-Mediated Gli1/Notch1 Signaling is a Key Regulator of Mesenchymal Stem Cell Immunomodulation in Liver Inflammatory Injury

    D. Xu, M. Sheng, Y. Lin, Y. Tian, Y. Zhan, C. Li, A. J. Coito, R. W. Busuttil, D. G. Farmer, J. W. Kupiec-Weglinski, B. Ke

    Surgery, Dumont - UCLA Transplant Center, Los Angeles, CA

    *Purpose: The CD47-signal regulatory protein alpha (SIRPα) signaling pathway plays important roles in immune homeostasis and tissue inflammatory response. Gli1, the downstream effector of the…
  • 2021 American Transplant Congress

    Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation

    R. Lathan, P. Mark, M. Clancy, R. Touyz

    Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

    *Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
  • 2021 American Transplant Congress

    First Full Reversal of Diabetes in Non-human Primates (nhp) with Stem Cell Derived Islet-like-clusters (sc-ilcs)

    J. Lei1, S. Collins2, H. Deng1, Z. Yang1, A. Zhang1, C. Peters1, J. Zhang2, K. Boulanger2, M. Yu3, M. Rickels3, C. Liu3, R. Pop2, A. Naji3, D. Melton2, J. Markmann1

    1Surgery, Mass General, Boston, MA, 2Harvard Stem Cell Institute, Harvard University, Boston, MA, 3Surgery, Upenn, Philadelphia, PA

    *Purpose: Deceased donor allo-islet transplants (Tx) have demonstrated the ability of cell-based therapy to fully reverse T1D, however, an inadequate donor supply and frequent need…
  • 2021 American Transplant Congress

    Human Liver-derived Mesenchymal Stromal Cells (MSC) are Superior Inhibitors of Natural Killer Cells Compared to Bone Marrow or Adipose Tissue-derived MSC

    F. Yigitbilek, M. J. Hansen, W. D. Park, M. D. Stegall, T. Taner

    Mayo Clinic, Rochester, MN

    *Purpose: Guided by the liver allografts’ unique tolerogenic microenvironment and the immunoprotective impact on simultaneously transplanted organs, we recently isolated liver mesenchymal stromal cells (L-MSC)…
  • 2021 American Transplant Congress

    Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients

    J. Leventhal1, J. Galvin2, J. Mathew1, L. Gallon1, D. Belshe1, M. Gibson1, K. Ravindra3, M. Horwitz3, S. Ildstad4

    1Northwestern University, Comprehensive Transplant Center, Chicago, IL, 2Northwestern University, Chicago, IL, 3Duke Medical Center, Durham, NC, 4University of Louisville, Llouisville, KY

    *Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor renal…
  • 2021 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar1, J. Weiss2, C. Phillips2, E. Malin2, V. Gorantla3, J. Harding4

    1Clinical Investigation, United States Army, Tacoma, WA, 2Clinical Investigation, Madigan Army Medical Center, Tacoma, WA, 3Surgery, Wake Forest University, Winston-Salem, NC, 4Neuroscience, Washington State Universisty, Pullman, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
  • 2021 American Transplant Congress

    Segmental Susceptibility of Intestinal Stem Cells to Cold Storage Preservation Injury in a Porcine Model

    E. K. Ludwig1, N. Abraham2, D. Sudan2, A. Barbas2, C. Schaaf1, J. Freund1, A. S. Stewart1, B. Veerasammy1, L. M. Gonzalez1

    1North Carolina State University, Raleigh, NC, 2Duke University, Durham, NC

    *Purpose: Cold storage (CS) is the current gold standard preservation method for small bowel (SB) prior to transplantation. However, CS can cause epithelial detachment, sloughing,…
  • 2021 American Transplant Congress

    MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update

    D. Kaufman1, S. Akkina2, M. Stegall3, J. Piper4, A. O. Gaber5, E. Marin6, S. Busque7, D. Alonso8, M. De Vera9, A. Shah10, A. Patel11, K. Chavin12, M. Laftavi13, S. Collette14, E. Stites15, M. Mai16, M. Cooper17, D. Brennan18

    1Surgery, UW, Madison, WI, 2Surgery, Loyola, Chicago, IL, 3Surgery, Mayo, Rochester, MN, 4Surgery, Inova, Fairfax, VA, 5Surgery, Houston Methodist, Houston, TX, 6Nephrology, Yale, New Haven, CT, 7Surgery, Stanford, San Francisco, CA, 8Surgery, Intermountain, Murray, UT, 9Surgery, Loma Linda, Loma Linda, CA, 10Surgery, TJU, Philadelphia, PA, 11Nephrology, St. Barnabas, Livingston, NJ, 12Surgery, UHH, Cincinnati, OH, 13Surgery, Upstate, Syracuse, NY, 14Surgery, CIUSSS, Montreal, ON, Canada, 15Nephrology, UC Denver, Denver, CO, 16Nephrology, Mayo - FL, Jacksonville, FL, 17Surgery, Georgetown, Washington, DC, 18Medeor, San Francisco, CA

    *Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…
  • 2020 American Transplant Congress

    Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis

    Y. Jia, M. Xu, T. Zhu

    Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
  • 2020 American Transplant Congress

    Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation

    K. Rozenberg1, S. Lohmann2, M. Pool3, M. Eijken4, U. Møldrup5, B. Møller6, J. Sierra-Parraga7, M. Hoogduijn7, L. Lo Faro1, C. Moers3, J. Hunter1, A. Keller2, H. Leuvenink3, C. Baan7, R. Ploeg1, B. Jespersen2

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, 4Department of Renal Medicine, Aarhus University, Aarhus, Denmark, 5Department of Urology, Aarhus University, Aarhus, Denmark, 6Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, 7Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands

    *Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
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