Articles tagged "Stem cells"

2015 American Transplant Congress
Ex Vivo Stem Cell-Mediated Regeneration of Ischemically Damaged Renal Allografts
L. Brasile, N. Henry, A. Meyer, B. Stubenitsky.
BREONICS, Inc., Watervliet, NY.
This project attempted to accelerate repair of ischemically damaged human kidney allografts using Exsanguinous Metabolic Support (EMS) technology that is warm (32C) and acellular. While…
2015 American Transplant Congress
Pre-Trasplant Perfusion With Mesenchymal Stromal Cells of Renal Graft Prevents Ischemia Injury Upregulating Gene Involved in Energy Saving
V. Corradetti,¹ S. Milanesi,¹ E. Pattonieri,¹ C. Rocca,¹ T. Valsania,¹ M. Gregorini,¹ L. De Cecco,² I. Benzoni,³ C. Bianco,³ M. Avanzini,⁴ M. Maestri,³ P. Esposito,¹ T. Rampino,¹ A. Dal Canton.
¹Unit of Nephrology, Dialysis and Transplantation, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; ²Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy; ³Unit of General Surgery, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; ⁴Cell Factory Pediatric Oncohaematology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
Background. Kidney ischemia from Donation after Circulatory Death shifts cells to anaerobic metabolism. Mesenchymal Stromal Cells (MSC) have immunomodulatory properties that are mediated by soluble…
2015 American Transplant Congress
Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival
N. Kenyon,¹ M. Willman,¹ H. Dongmei,¹ H. Ana,¹ A. Rabassa,¹ W. Diaz,¹ J. Geary,¹ N. Kenyon,¹ A. Bartholomew,² K. McHenry,³ D. Salomon,⁴ D. Berman.¹
¹Surgery, University of Miami School of Medicine, Miami, FL; ²Surgery, University of Illinois at Chicago, Chicago, IL; ³National Center for Supercomputing and Analysis, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL; ⁴Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
The purpose of this study was 1) to assess the effect of mesenchymal stem cells (MSC) on intrahepatic, allogeneic islet survival in a cynomolgus monkey…
2015 American Transplant Congress
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft
X. Zhang,¹ Y. Gong,² K. Jiang,² C. Wang,² T. Xia,² J. Li,² J. Wang,² J. Nie.²
¹Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; ²Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
2015 American Transplant Congress
Stem Cell and Novel Biologic Therapies to Enhance Functional Recovery in Limb Transplantation
K. Kniery, M. DeHart, T. Brown, S. Salgar.
Surgery/Clinical Investigation, Madigan Army Medical Center, Tacoma, WA.
Introduction: Unlike visceral organ transplants, vascular composite allotransplantation such as limb and face require successful nerve regeneration and reinnervation of graft motor and sensory targets…
2015 American Transplant Congress
MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo
D. Joyce,¹ M. Morita,² X.-K. Li,³ J. Fung,¹ S. Qian,^1,2 L. Lu.^1,2
¹General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; ³Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
2015 American Transplant Congress
Tissue Distribution, Preparation and Phenotype Characteristics of Stem Cells Originated from the Organs of Deceased Human Individuals
A. Klimczak,¹ T. Jurek,² M. Czuba,² U. Kozlowska,¹ M. Rorat,² K. Wrzeszcz.¹
¹Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland; ²Department of Forensic Medicine, Medical University, Wroclaw, Poland.
Objective: Multipotent stem cells are unique cells present in several human organs that have self-renewing properties and are able to differentiate into diverse specialized cell…
2015 American Transplant Congress
Human iPS Cell-Derived Pancreatic β-Cells Correct Hyperglycemia in Diabetic Mice
G. Manzar,^1,2,3 E.-M. Kim,^1,2 P. Rotti,³ N. Zavazava.^1,2,3
¹Internal Medicine, University of Iowa, Iowa City, IA; ²VA Medical Center, Iowa City, IA; ³Biomedical Engineering, University of Iowa, Iowa City, IA.
Type I diabetes (T1D) is an autoimmune disorder that leads to the destruction of pancreatic β-cells. The consequences of T1D are dysregulation of metabolism leading…
2015 American Transplant Congress
Induction of iNOS Expressed Macrophages from Mouse iPS cells That Contribute to Prolong Same iPS Cells-Derived Graft Survival in Allogeneic Recipients
H. Sasaki,¹ H. Wada,² K. Morita,¹ K.-I. Seino,² N. Shinohara.¹
¹Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
BACKGROUND: Induced pluripotent stem cells (iPSCs)-technology provides new opportunities in regenerative medicine to generate grafts from donors for transplantation. However, particularly when allogeneic iPSCs are…