ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2015 American Transplant Congress

    Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers

    J. Leventhal,1 J. Mathew,1 D. Salomon,2 S. Kurian,2 J. Friedewald,1 L. Gallon,1 I. Konieczna,1 A. Tambur,1 J. Levitsky,1 Y. Kanwar,1 C. Jie,1 M. Abecassis,1 J. Miller.1

    1CTC, Northwestern University, Chicago, IL; 2Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA.

    Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…
  • 2015 American Transplant Congress

    Cardiosphere-Derived Cells from Cadaver Can Improve Heart Function in a Model of Non-Ischaemic Dilated Cardiomyopathy

    J. Wu,1,2 Y. Sun,1,2 M. Tan,3 D. Chi,1,2 M. Zhang,1,2 K. Kang,4 X. Jin,5 B. Yu.1,2

    1Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; 2Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; 3Cardiology, The First Hospital of Fangshan District, Beijing, China; 4Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; 5Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.

    Objectives: Cardiosphere-derived cells (CDCs) are mainly obtained through myocardial biopsy, and could improve cardiac function and attenuate remodeling in myocardial infarction. In this study, we…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases

    G. Saadi,1 K. Eweda,2 M. Hassaballa,1 F. Fadel,3 E. Aziz,2 M. Roshdi,1 M. El Ansary,4 I. Aziz,4 W. Ismail,5 A. Atef,1 S. Hamid.4

    1Internal Medicine and Nephrology, Cairo University, Cairo, Egypt; 2Nephrology, Army Hospital, Cairo, Egypt; 3Pediatric Nephrology, Cairo University, Cairo, Egypt; 4Clinical Pathology, Cairo University, Cairo, Egypt; 5Pathology, Beni Sweif University, Beni Sweif City, Egypt.

    Immunomodulatory function of MSCs may correct positive PRA or LCM in highly-sensitized patients. We evaluate donor specific or 3rd party MSCs transfusion in 16 patients…
  • 2015 American Transplant Congress

    Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants

    T. Pham,1 S. Busque,1 J. Scandling,2 J. Shizuru,2 S. Asha,1 S. Strober.2

    1Surgery, Stanford University, Palo Alto, CA; 2Medicine, Stanford University, Palo Alto, CA.

    Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants

    H. Wang,1,2 W. Tian,1 Y. Liu,3 X. Dai,1 G. Li,3 T. Liu,1,2 Z. Zhang,1,2 C. Du.4

    1Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; 2Tianjin General Surgery Institute, Tianjin, China; 3Department of Biology, Tianjin Medical University, Tianjin, China; 4Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.

    Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
  • 2015 American Transplant Congress

    Vaccine Responses in Combined Hematopoeitic Stem Cell-Kidney Transplant Recipients

    C. Feng,1 M. Ison,1 J. Galvin,1 S. Ildstad,2,3 D. Stare,1 J. Leventhal.1

    1Northwestern University, Chicago, IL; 2University of Louisville, Louisville, KY; 3Regenerex, LLC, Louisville, KY.

    Background: Vaccines remain one of the most effective methods of preventing infections following transplantation. Data suggests that vaccine responses are reduced in recipients of hematopoeitic…
  • 2015 American Transplant Congress

    Six Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients

    J. Leventhal, M. Abecassis, L. Gallon, J. Galvin, J. Mehta, K. Ravindra, D. Tollerud, M. Elliott, S. Ildstad.

    Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; Duke University, Durham, NC; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY.

    27 subjects have been transplanted in a phase 2 protocol (IDE 13947) based upon tolerogenic CD8+/TCR- facilitating cells (FCRx) and 200 cGy TBI-based nonmyeloablative conditioning…
  • 2015 American Transplant Congress

    Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice

    N. Nayakawde, P. Patil, K. Methe, M. Olausson.

    Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
  • 2015 American Transplant Congress

    A Novel Humanized Mouse Model for the Study of Induced Pluripotent Stem Cell-Derived Tissue Transplantation Tolerance and Function

    M. Brown, I. Norman, Y. Zhou, J. Sullivan, W. Burlingham.

    Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.

    Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine therapies, theoretically allowing for the creation of autologous replacement tissues devoid of many…
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