Articles tagged "Stem cells"

2015 American Transplant Congress
Third Party Mesenchymal Stromal Cell Infusion in Kidney Transplant Recipient: 6-Month Safety Interim Analysis
L. Weekers,¹ P. Erpicum,¹ O. Detry,³ C. Lechanteur,² E. Baudoux,² F. Jouret,¹ Y. Beguin.²
¹Nephrology, University Hospital of Liege, Liege, Belgium; ²Hematology, University Hospital of Liege, Liege, Belgium; ³Abdominal Surgery, University Hospital of Liege, Liege, Belgium.
Back-groundMesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents.We report the 6-month safety results for the 5 first patients treated…
2015 American Transplant Congress
Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)
A. Scheinok, R. Elahimehr, A. Shigeoka, S. Kasimsetty, D. McKay.
Medicine, University of California San Diego, San Diego, CA.
HSCs are activated by pattern recognition receptors (PRRs), which might provide novel targets for improved engraftment. How PRRs affect HSC engraftment after BM transplantation is…
2015 American Transplant Congress
Bioengineering Liver Allografts through Organ Scaffold Recellularization
J. Woodall, J. Langford, C. Klassen, J. Harrison, D. Parsell, U. Dhru, R. Barth, J. LaMattina.
University of Maryland School of Medicine, Baltimore.
Bioengineering livers using organ scaffolds offers an approach to increasing allograft availability for end stage liver disease. Recellularized liver scaffolds will require multiple differentiated cell…
2015 American Transplant Congress
Interleukin-17A Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Grey,⁵ C. Hope,^1,2 R. Carroll,^1,4 S. Gronthos,^3,6 P. Coates.^1,2,3,4
¹Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ²School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia; ⁴Central Northern Adelaide Renal Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ⁵Transplantation Immunology Group, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; ⁶Mesenchymal Stem Cell Laboratory, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Interferon-gamma preactivated mesenchymal stem cells (MSC-γ) are highly immunosuppressive but immunogenic in vivo due to their inherent expression of major histocompatibility (MHC) molecules. We modified…
2015 American Transplant Congress
Mesenchymal Stromal Cells (MSCs) Given Post-Transplant Together With C3a and C5a Receptor Antagonists Prevent Engraftment Syndrome and Induce a Mild Not-Significant Prolongation of Graft Survival
F. Casiraghi,¹ M. Todeschini,¹ N. Azzollini,¹ P. Cravedi,² P. Heeger,² P. Cassis,¹ S. Solini,¹ N. Perico,¹ M. Noris,¹ G. Remuzzi.¹
¹IRCSS Mario Negri Institute, Bergamo, Italy; ²Icahn School of Medicine at Mount Sinai, New York, NY.
Bone marrow (BM)-derived MSC given the day before kidney allografts localize into lymphoid organs and induce significant prolongation of graft survival in mice. By contrast,…
2015 American Transplant Congress
CD8⁺TCR^– Bone Marrow Facilitating Cells Prime Migration and Enhance Homing of Hematopoietic Stem and Progenitor Cells
Y. Wen,¹ Y. Huang,¹ T. Miller,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
We recently reported the induction of chimerism and tolerance to renal allografts without GVHD or engraftment syndrome in HLA-mismatched living donor renal transplant recipients through…
2015 American Transplant Congress
Detergent-Sonication Method for the Whole Laryngeal Decellularization
N. Nayakawde,¹ K. Methe,¹ M. Berg,² G. Premaratne,¹ H. Ejnell,² M. Olausson.¹
¹Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden; ²Departments of 1Otolaryngology, Head and Neck Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.
Background: Each year, about 136,000 individuals worldwide are diagnosed with larynx carcinoma. Tissue engineered organs shows promising alternative to a conventional transplantation in both preclinical…
2015 American Transplant Congress
A Preliminary Study of Using Small Intestinal Submucosa Scaffolds Coated Islets and Mesenchymal Stem Cells to Built Artificial Pancreas
D. Wang, X. Ding, W. Xue, J. Zheng, X. Feng, X. Tian, Y. Li.
Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Background: Although islet transplantation successful applied, shortage of donors, poor islet survival and toxicity of immunosuppressants often reduce the graft functional lifetime. Tissue engineered scaffold…
2015 American Transplant Congress
Mesenchymal Stem Cell Therapy to Improve Functional Outcome in Vascular Composite Allotransplantation (VCA)
S. Salgar, J. Bingham, M. DeHart, J. Tercero, T. Brown.
Madigan Army Medical Center, Tacoma.
Introduction: Although over 200 VCA including hand and face transplants have been performed worldwide with encouraging graft survival outcomes, long-term success with motor and sensory…