Articles tagged "Stem cells"

2015 American Transplant Congress
Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ I. Konieczna,¹ A. Tambur,¹ J. Levitsky,¹ Y. Kanwar,¹ C. Jie,¹ M. Abecassis,¹ J. Miller.¹
¹CTC, Northwestern University, Chicago, IL; ²Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA.
Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…
2015 American Transplant Congress
Cardiosphere-Derived Cells from Cadaver Can Improve Heart Function in a Model of Non-Ischaemic Dilated Cardiomyopathy
J. Wu,^1,2 Y. Sun,^1,2 M. Tan,³ D. Chi,^1,2 M. Zhang,^1,2 K. Kang,⁴ X. Jin,⁵ B. Yu.^1,2
¹Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiology, The First Hospital of Fangshan District, Beijing, China; ⁴Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Objectives: Cardiosphere-derived cells (CDCs) are mainly obtained through myocardial biopsy, and could improve cardiac function and attenuate remodeling in myocardial infarction. In this study, we…
2015 American Transplant Congress
Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases
G. Saadi,¹ K. Eweda,² M. Hassaballa,¹ F. Fadel,³ E. Aziz,² M. Roshdi,¹ M. El Ansary,⁴ I. Aziz,⁴ W. Ismail,⁵ A. Atef,¹ S. Hamid.⁴
¹Internal Medicine and Nephrology, Cairo University, Cairo, Egypt; ²Nephrology, Army Hospital, Cairo, Egypt; ³Pediatric Nephrology, Cairo University, Cairo, Egypt; ⁴Clinical Pathology, Cairo University, Cairo, Egypt; ⁵Pathology, Beni Sweif University, Beni Sweif City, Egypt.
Immunomodulatory function of MSCs may correct positive PRA or LCM in highly-sensitized patients. We evaluate donor specific or 3rd party MSCs transfusion in 16 patients…
2015 American Transplant Congress
Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants
T. Pham,¹ S. Busque,¹ J. Scandling,² J. Shizuru,² S. Asha,¹ S. Strober.²
¹Surgery, Stanford University, Palo Alto, CA; ²Medicine, Stanford University, Palo Alto, CA.
Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Vaccine Responses in Combined Hematopoeitic Stem Cell-Kidney Transplant Recipients
C. Feng,¹ M. Ison,¹ J. Galvin,¹ S. Ildstad,^2,3 D. Stare,¹ J. Leventhal.¹
¹Northwestern University, Chicago, IL; ²University of Louisville, Louisville, KY; ³Regenerex, LLC, Louisville, KY.
Background: Vaccines remain one of the most effective methods of preventing infections following transplantation. Data suggests that vaccine responses are reduced in recipients of hematopoeitic…
2015 American Transplant Congress
Six Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients
J. Leventhal, M. Abecassis, L. Gallon, J. Galvin, J. Mehta, K. Ravindra, D. Tollerud, M. Elliott, S. Ildstad.
Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; Duke University, Durham, NC; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY.
27 subjects have been transplanted in a phase 2 protocol (IDE 13947) based upon tolerogenic CD8+/TCR- facilitating cells (FCRx) and 200 cGy TBI-based nonmyeloablative conditioning…
2015 American Transplant Congress
Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice
N. Nayakawde, P. Patil, K. Methe, M. Olausson.
Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.
Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
2015 American Transplant Congress
A Novel Humanized Mouse Model for the Study of Induced Pluripotent Stem Cell-Derived Tissue Transplantation Tolerance and Function
M. Brown, I. Norman, Y. Zhou, J. Sullivan, W. Burlingham.
Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.
Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine therapies, theoretically allowing for the creation of autologous replacement tissues devoid of many…
2015 American Transplant Congress
Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function
M. Lawrence,¹ F. Kunnathodi,¹ N. Borenstein-Auerbach,¹ G. Yoshimatsu,¹ M. Kanak,² R. Shahbazov,¹ M. Takita,¹ M. Levy,³ B. Naziruddin.³
¹Baylor Research Institute, Dallas, TX; ²Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…