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American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2015 American Transplant Congress

    Six Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Mismatched Living Donor Renal Transplant Recipients

    J. Leventhal, M. Abecassis, L. Gallon, J. Galvin, J. Mehta, K. Ravindra, D. Tollerud, M. Elliott, S. Ildstad.

    Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; Duke University, Durham, NC; Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; Regenerex, LLC, Louisville, KY.

    27 subjects have been transplanted in a phase 2 protocol (IDE 13947) based upon tolerogenic CD8+/TCR- facilitating cells (FCRx) and 200 cGy TBI-based nonmyeloablative conditioning…
  • 2015 American Transplant Congress

    Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice

    N. Nayakawde, P. Patil, K. Methe, M. Olausson.

    Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
  • 2015 American Transplant Congress

    A Novel Humanized Mouse Model for the Study of Induced Pluripotent Stem Cell-Derived Tissue Transplantation Tolerance and Function

    M. Brown, I. Norman, Y. Zhou, J. Sullivan, W. Burlingham.

    Surgery/Transplant Division, University of Wisconsin-Madison, Madison, WI.

    Patient-specific induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine therapies, theoretically allowing for the creation of autologous replacement tissues devoid of many…
  • 2015 American Transplant Congress

    Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function

    M. Lawrence,1 F. Kunnathodi,1 N. Borenstein-Auerbach,1 G. Yoshimatsu,1 M. Kanak,2 R. Shahbazov,1 M. Takita,1 M. Levy,3 B. Naziruddin.3

    1Baylor Research Institute, Dallas, TX; 2Baylor University, Waco, TX; 3Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.

    PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…
  • 2015 American Transplant Congress

    Ex Vivo Stem Cell-Mediated Regeneration of Ischemically Damaged Renal Allografts

    L. Brasile, N. Henry, A. Meyer, B. Stubenitsky.

    BREONICS, Inc., Watervliet, NY.

    This project attempted to accelerate repair of ischemically damaged human kidney allografts using Exsanguinous Metabolic Support (EMS) technology that is warm (32C) and acellular. While…
  • 2015 American Transplant Congress

    Pre-Trasplant Perfusion With Mesenchymal Stromal Cells of Renal Graft Prevents Ischemia Injury Upregulating Gene Involved in Energy Saving

    V. Corradetti,1 S. Milanesi,1 E. Pattonieri,1 C. Rocca,1 T. Valsania,1 M. Gregorini,1 L. De Cecco,2 I. Benzoni,3 C. Bianco,3 M. Avanzini,4 M. Maestri,3 P. Esposito,1 T. Rampino,1 A. Dal Canton.

    1Unit of Nephrology, Dialysis and Transplantation, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; 2Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy; 3Unit of General Surgery, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; 4Cell Factory Pediatric Oncohaematology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.

    Background. Kidney ischemia from Donation after Circulatory Death shifts cells to anaerobic metabolism. Mesenchymal Stromal Cells (MSC) have immunomodulatory properties that are mediated by soluble…
  • 2015 American Transplant Congress

    Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival

    N. Kenyon,1 M. Willman,1 H. Dongmei,1 H. Ana,1 A. Rabassa,1 W. Diaz,1 J. Geary,1 N. Kenyon,1 A. Bartholomew,2 K. McHenry,3 D. Salomon,4 D. Berman.1

    1Surgery, University of Miami School of Medicine, Miami, FL; 2Surgery, University of Illinois at Chicago, Chicago, IL; 3National Center for Supercomputing and Analysis, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL; 4Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.

    The purpose of this study was 1) to assess the effect of mesenchymal stem cells (MSC) on intrahepatic, allogeneic islet survival in a cynomolgus monkey…
  • 2015 American Transplant Congress

    Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft

    X. Zhang,1 Y. Gong,2 K. Jiang,2 C. Wang,2 T. Xia,2 J. Li,2 J. Wang,2 J. Nie.2

    1Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China; 2Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.

    Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…
  • 2015 American Transplant Congress

    Stem Cell and Novel Biologic Therapies to Enhance Functional Recovery in Limb Transplantation

    K. Kniery, M. DeHart, T. Brown, S. Salgar.

    Surgery/Clinical Investigation, Madigan Army Medical Center, Tacoma, WA.

    Introduction: Unlike visceral organ transplants, vascular composite allotransplantation such as limb and face require successful nerve regeneration and reinnervation of graft motor and sensory targets…
  • 2015 American Transplant Congress

    MDSC Derived from iPS Cells Regulate the CD8 T Cell Response In Vivo

    D. Joyce,1 M. Morita,2 X.-K. Li,3 J. Fung,1 S. Qian,1,2 L. Lu.1,2

    1General Surgery, Digestive Disease Institute; 2Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 3Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.

    Myeloid derived suppressor cells (MDSC) may represent a therapeutic tool for inducing tolerance in transplantation and autoimmune disorders. MDSC propagated from bone marrow (BM) can…
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