ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2015 American Transplant Congress

    Induction of iNOS Expressed Macrophages from Mouse iPS cells That Contribute to Prolong Same iPS Cells-Derived Graft Survival in Allogeneic Recipients

    H. Sasaki,1 H. Wada,2 K. Morita,1 K.-I. Seino,2 N. Shinohara.1

    1Genitourinary Surgery, Hokkaido University, Sapporo, Japan; 2Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.

    BACKGROUND: Induced pluripotent stem cells (iPSCs)-technology provides new opportunities in regenerative medicine to generate grafts from donors for transplantation. However, particularly when allogeneic iPSCs are…
  • 2015 American Transplant Congress

    Conditioning of Mesenchymal Stromal Cells With mTOR Inhibitor Enhances Regenerative Properties of Secretome and Attenuates Vascular Calcification

    B. Hegner,1 C. Kurth,1 T. Schaub,1 C. Lange,2 D. Dragun.1

    1Clinic for Nephrology and Intensive Care Medicine, Charité University Hospital, Berlin, Germany; 2Department of Cell and Gene Therapy, University Medical Center Eppendorf, Hamburg, Germany.

    Similar to patients with chronic kidney disease, recipients of kidney transplants are a high-risk population for cardiovascular events due to arterial media calcification in particular…
  • 2015 American Transplant Congress

    Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)

    E.-M. Kim, G. Manzar, N. Zavazava.

    Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA.

    Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…
  • 2015 American Transplant Congress

    PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization

    E. Kefalogianni,1 M. Mounayar,2 B. Smith,2 J. Azzi,2 L. Chabtini,2 P. Fiorina,2 M. Kraus,3 R. Briddell,4 W. Fodor,5 A. Herrlich,1 R. Abdi.2

    1Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Transplantation Research Center, Brigham and Women's and Children's Hospital, Harvard Medical School, Boston, MA; 3Viacord LLC, a PerkinElmer Company, Cambridge, MA; 4ViaCord Processing Lab, Viacord LLC, a PerkinElmer Company, Hebron, KY; 5The Cell Therapy Group, Madison, CT.

    The immunomodulatory capacity of mesenchymal stem cells (MSC) is critical for their use in therapeutic applications. MSC response to specific inflammatory cues allows them to…
  • 2015 American Transplant Congress

    Phenotype Characterization, Migratory Pathways, Engraftment and Safety Evaluation of Human Cord Blood Derived Ex-Vivo Created Di- Chimeric Cells in NOD SCID Mouse Model: A Preliminary Study

    J. Cwykiel,1 A. Sklodowska,1 W. Malewski,1 M. Cyran,1 H. Karagoz,1 E. Bryndza Tfaily,1 M. Askar,2 M. Siemionow.1

    1Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL; 2Transplant Center, Cleveland Clinic, Cleveland, OH.

    PURPOSE: The aim of this study was to evaluate safety, survival, migration and engraftment of ex-vivo fused human cord blood derived di-chimeric cells (DCC) in…
  • 2015 American Transplant Congress

    Human CD8+TCR– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro

    Y. Huang,1 M. Elliott,1 E. Yolcu,1 T. Miller,1 L. Bozulic,2 Y. Wen,1 H. Xu,1 S. Ildstad.1,2

    1Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; 2Regenerex, LLC, Louisville, KY.

    CD8+/TCR- facilitating cells (FC) in mouse BM significantly enhance engraftment of hematopoietic stem cells (HSC) in syngeneic and allogeneic recipients. Human FC phenotype and mechanism…
  • 2015 American Transplant Congress

    Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation

    E. Bryndza Tfaily,1 J. Cwykiel,1 K. Dastych,2 A. Sklodowska,1 M. Siemionow.1

    1Orthopaedics, University of Illinois at Chicago, Chicago, IL; 2Pathology, University of Illinois at Chicago, Chicago, IL.

    Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…
  • 2015 American Transplant Congress

    Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells

    R. Bascom, K. Tao, S. Tollenaar, L. West.

    University of Alberta, Edmonton, Canada.

    Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…
  • 2015 American Transplant Congress

    Third Party Mesenchymal Stromal Cell Infusion in Kidney Transplant Recipient: 6-Month Safety Interim Analysis

    L. Weekers,1 P. Erpicum,1 O. Detry,3 C. Lechanteur,2 E. Baudoux,2 F. Jouret,1 Y. Beguin.2

    1Nephrology, University Hospital of Liege, Liege, Belgium; 2Hematology, University Hospital of Liege, Liege, Belgium; 3Abdominal Surgery, University Hospital of Liege, Liege, Belgium.

    Back-groundMesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents.We report the 6-month safety results for the 5 first patients treated…
  • 2015 American Transplant Congress

    Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)

    A. Scheinok, R. Elahimehr, A. Shigeoka, S. Kasimsetty, D. McKay.

    Medicine, University of California San Diego, San Diego, CA.

    HSCs are activated by pattern recognition receptors (PRRs), which might provide novel targets for improved engraftment. How PRRs affect HSC engraftment after BM transplantation is…
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