Articles tagged "Stem cells"

2016 American Transplant Congress
Improved Regeneration of the Remnant Liver After Extended Hepatectomy or Partial Liver Transplantation by Pharmacologic Mobilization of Endogenous Stem Cells in Rats.
M. Chen, R. Zhai, L. Qi, A. Cameron, B. Philosophe, Z. Sun.
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
BackgroundRapid regeneration of the remnant liver after extended partial hepatectomy or reduced size liver transplantation is essential to prevent small-for-size syndrome (SFSS). We hypothesize that…
2015 American Transplant Congress
Immune Reconstitution in Recipients of Living Donor Kidney/Hematopoietic Stem + Facilitating Cell Transplants
J. Leventhal,¹ M. Elliott,² E. Yolcu,² L. Bozulic,³ D. Tollerud,³ J. Mathew,¹ I. Konieczna,¹ M. Ison,¹ M. Badder,³ M. Abecassis,¹ J. Miller,¹ L. Gallon,¹ S. Ildstad.³
¹Comprehensive Transplant Center, Northwestern Memorial Hospital, Chicago, IL; ²University of Louisville, Institute for Cellular Therapeutics, Louisville, KY; ³Regenerex, LLC, Louisville, KY.
We report the long-term results from a reduced-intensity nonmyeloablative conditioning approach to establish high levels of donor chimerism without graft-versus-host disease (GVHD) in mismatched related…
2015 American Transplant Congress
Living and Dead Mesenchymal Stem Cells Induce an Immunosuppressive Response in an Experimental Sepsis Model
F. Luk,¹ M. Roemeling-van Rhijn,¹ S. de Witte,¹ S. Korevaar,¹ R. de Bruin,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹
¹Nephrology and Transplantation, Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; ²Transplant Surgery, Dept. of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
There is evolving interest in the use of mesenchymal stem cells (MSC) as a cell therapeutic agent after solid organ transplantation. The nature of the…
2015 American Transplant Congress
Inside Out Autologous Neo-Liver Fabrication
P. Than, C. Davis, M. Findlay, W. Liu, T. Le, S. Khong, M. Melcher, G. Gurtner.
Surgery, Stanford University School of Medicine, Stanford, CA.
Background: Creation of patient-specific replacement organs promises to address major shortcomings in transplantation. We previously described an approach to fabricate autologous, vascularized neo-organs by using…
2015 American Transplant Congress
Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers
J. Leventhal,¹ J. Mathew,¹ D. Salomon,² S. Kurian,² J. Friedewald,¹ L. Gallon,¹ I. Konieczna,¹ A. Tambur,¹ J. Levitsky,¹ Y. Kanwar,¹ C. Jie,¹ M. Abecassis,¹ J. Miller.¹
¹CTC, Northwestern University, Chicago, IL; ²Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA.
Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…
2015 American Transplant Congress
Cardiosphere-Derived Cells from Cadaver Can Improve Heart Function in a Model of Non-Ischaemic Dilated Cardiomyopathy
J. Wu,^1,2 Y. Sun,^1,2 M. Tan,³ D. Chi,^1,2 M. Zhang,^1,2 K. Kang,⁴ X. Jin,⁵ B. Yu.^1,2
¹Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China; ²Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiology, The First Hospital of Fangshan District, Beijing, China; ⁴Cardiovascular Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Objectives: Cardiosphere-derived cells (CDCs) are mainly obtained through myocardial biopsy, and could improve cardiac function and attenuate remodeling in myocardial infarction. In this study, we…
2015 American Transplant Congress
Mesenchymal Stem Cells (MSCs) Transfusion for Desensitization of Positive Lymphocyte Cross Match (LCM) or Panel Reactive Antibodies (PRA) Before Kidney Transplantation – Outcome of 16 Cases
G. Saadi,¹ K. Eweda,² M. Hassaballa,¹ F. Fadel,³ E. Aziz,² M. Roshdi,¹ M. El Ansary,⁴ I. Aziz,⁴ W. Ismail,⁵ A. Atef,¹ S. Hamid.⁴
¹Internal Medicine and Nephrology, Cairo University, Cairo, Egypt; ²Nephrology, Army Hospital, Cairo, Egypt; ³Pediatric Nephrology, Cairo University, Cairo, Egypt; ⁴Clinical Pathology, Cairo University, Cairo, Egypt; ⁵Pathology, Beni Sweif University, Beni Sweif City, Egypt.
Immunomodulatory function of MSCs may correct positive PRA or LCM in highly-sensitized patients. We evaluate donor specific or 3rd party MSCs transfusion in 16 patients…
2015 American Transplant Congress
Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants
T. Pham,¹ S. Busque,¹ J. Scandling,² J. Shizuru,² S. Asha,¹ S. Strober.²
¹Surgery, Stanford University, Palo Alto, CA; ²Medicine, Stanford University, Palo Alto, CA.
Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…
2015 American Transplant Congress
Mesenchymal Stem Cells Prevent Cold Ischemia-Reperfusion Injury in Lung Transplants
H. Wang,^1,2 W. Tian,¹ Y. Liu,³ X. Dai,¹ G. Li,³ T. Liu,^1,2 Z. Zhang,^1,2 C. Du.⁴
¹Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China; ²Tianjin General Surgery Institute, Tianjin, China; ³Department of Biology, Tianjin Medical University, Tianjin, China; ⁴Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada.
Background: Cold ischemia-reperfusion injury (IRI) is a major cause of graft failure in lung transplantation. Despite therapeutic benefits of mesenchymal stem cells (MSCs) in attenuating…
2015 American Transplant Congress
Vaccine Responses in Combined Hematopoeitic Stem Cell-Kidney Transplant Recipients
C. Feng,¹ M. Ison,¹ J. Galvin,¹ S. Ildstad,^2,3 D. Stare,¹ J. Leventhal.¹
¹Northwestern University, Chicago, IL; ²University of Louisville, Louisville, KY; ³Regenerex, LLC, Louisville, KY.
Background: Vaccines remain one of the most effective methods of preventing infections following transplantation. Data suggests that vaccine responses are reduced in recipients of hematopoeitic…