Articles tagged "Stem cells"

2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2015 American Transplant Congress
Conditioning of Mesenchymal Stromal Cells With mTOR Inhibitor Enhances Regenerative Properties of Secretome and Attenuates Vascular Calcification
B. Hegner,¹ C. Kurth,¹ T. Schaub,¹ C. Lange,² D. Dragun.¹
¹Clinic for Nephrology and Intensive Care Medicine, Charité University Hospital, Berlin, Germany; ²Department of Cell and Gene Therapy, University Medical Center Eppendorf, Hamburg, Germany.
Similar to patients with chronic kidney disease, recipients of kidney transplants are a high-risk population for cardiovascular events due to arterial media calcification in particular…
2015 American Transplant Congress
Immune Rejection of iPS Cells Is Triggered By Gamete-Associated Proteins (GAPs)
E.-M. Kim, G. Manzar, N. Zavazava.
Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA; Internal Medicine, University of Iowa, Iowa City, IA.
Induced pluripotent stem (iPS) cells have emerged as a new source for cell based therapies. However, the safety of iPS cells in autologous recipients has…
2015 American Transplant Congress
PI3Kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization
E. Kefalogianni,¹ M. Mounayar,² B. Smith,² J. Azzi,² L. Chabtini,² P. Fiorina,² M. Kraus,³ R. Briddell,⁴ W. Fodor,⁵ A. Herrlich,¹ R. Abdi.²
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA; ²Transplantation Research Center, Brigham and Women's and Children's Hospital, Harvard Medical School, Boston, MA; ³Viacord LLC, a PerkinElmer Company, Cambridge, MA; ⁴ViaCord Processing Lab, Viacord LLC, a PerkinElmer Company, Hebron, KY; ⁵The Cell Therapy Group, Madison, CT.
The immunomodulatory capacity of mesenchymal stem cells (MSC) is critical for their use in therapeutic applications. MSC response to specific inflammatory cues allows them to…
2015 American Transplant Congress
Phenotype Characterization, Migratory Pathways, Engraftment and Safety Evaluation of Human Cord Blood Derived Ex-Vivo Created Di- Chimeric Cells in NOD SCID Mouse Model: A Preliminary Study
J. Cwykiel,¹ A. Sklodowska,¹ W. Malewski,¹ M. Cyran,¹ H. Karagoz,¹ E. Bryndza Tfaily,¹ M. Askar,² M. Siemionow.¹
¹Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL; ²Transplant Center, Cleveland Clinic, Cleveland, OH.
PURPOSE: The aim of this study was to evaluate safety, survival, migration and engraftment of ex-vivo fused human cord blood derived di-chimeric cells (DCC) in…
2015 American Transplant Congress
Human CD8⁺TCR^– Facilitating Cells Enhance HSC Engraftment In Vivo and Promote HSC Survival In Vitro
Y. Huang,¹ M. Elliott,¹ E. Yolcu,¹ T. Miller,¹ L. Bozulic,² Y. Wen,¹ H. Xu,¹ S. Ildstad.^1,2
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Regenerex, LLC, Louisville, KY.
CD8+/TCR- facilitating cells (FC) in mouse BM significantly enhance engraftment of hematopoietic stem cells (HSC) in syngeneic and allogeneic recipients. Human FC phenotype and mechanism…
2015 American Transplant Congress
Human Hematopoietic Chimeric Cells as a Novel Approach for Tolerance Induction After Transplantation
E. Bryndza Tfaily,¹ J. Cwykiel,¹ K. Dastych,² A. Sklodowska,¹ M. Siemionow.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago, IL; ²Pathology, University of Illinois at Chicago, Chicago, IL.
Background: Cellular therapies represent a new promising approach for transplant tolerance induction. One of the methods for immune response modulation in solid organ and vascularized…
2015 American Transplant Congress
Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells
R. Bascom, K. Tao, S. Tollenaar, L. West.
University of Alberta, Edmonton, Canada.
Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…
2015 American Transplant Congress
Third Party Mesenchymal Stromal Cell Infusion in Kidney Transplant Recipient: 6-Month Safety Interim Analysis
L. Weekers,¹ P. Erpicum,¹ O. Detry,³ C. Lechanteur,² E. Baudoux,² F. Jouret,¹ Y. Beguin.²
¹Nephrology, University Hospital of Liege, Liege, Belgium; ²Hematology, University Hospital of Liege, Liege, Belgium; ³Abdominal Surgery, University Hospital of Liege, Liege, Belgium.
Back-groundMesenchymal stromal cell (MSC) have immunomodulating properties and could be used as immunosuppressive agents.We report the 6-month safety results for the 5 first patients treated…
2015 American Transplant Congress
Differential Expression and Function of ASC and Nlrp3 Inflammasome Adaptors in Hematopoietic Stem Cells (HSCs)
A. Scheinok, R. Elahimehr, A. Shigeoka, S. Kasimsetty, D. McKay.
Medicine, University of California San Diego, San Diego, CA.
HSCs are activated by pattern recognition receptors (PRRs), which might provide novel targets for improved engraftment. How PRRs affect HSC engraftment after BM transplantation is…