Articles tagged "Stem cells"

2016 American Transplant Congress
IL-17A Preactivated Mesenchymal Stem Cells (MSC-17) Are Enriched for Genes Involved in T Cell Chemotaxis to Mediate Superior Immunosuppression.
K. Sivanathan,^1,2,3 D. Rojas-Canales,^1,2 S. Gronthos,⁴ S. Grey,⁵ P. Coates.^1,2,3
¹School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ²Centre for Clinical and Experimental Transplantation, Royal Adelaide Hospital, Adelaide, South Australia, Australia; ³Centre for Stem Cell Research and Robinson Institute, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁴Mesenchymal Stem Cell Laboratory, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia; ⁵Transplant Immunology Group, Garvin Institute of Medical Research, Sydney, New South Wales, Australia.
Human bone marrow derived MSC-17 are superior T cell immunomodulators for allotransplantation. Untreated-MSC (UT-MSC) or 5 days IFNγ (MSCγ) or IL-17A (MSC-17) treated MSC were…
2016 American Transplant Congress
Pathogenic Role of Anti-HLA Antibodies on Endothelial Progenitor Cell Dysfunction of Highly Sensitized Kidney Transplanted Patients.
V. Cantaluppi,¹ S. Dellepiane,² D. Medica,² G. Tognarelli,² M. Quaglia,¹ C. Musetti,¹ A. Airoldi,¹ L. Biancone.²
¹Nephrology, Dialysis and Kidney Transplantation Unit, University of Eastern Piedmont "A. Avogadro", Novara, Italy; ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Torino, Torino, Italy.
Anti-HLA antibodies (abs) bind to kidney graft endothelial cells inducing complement-mediated injury and humoral rejection. Endothelial Progenitor Cells (EPC) are bone marrow-derived precursors able to…
2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2016 American Transplant Congress
In Vitro Induction of T Regulatory Cells by Multipotent Adult Progenitor Cells.
S. Stubblefield, N. Williams, A. Ting.
Regenerative Medicine, Athersys, Inc, Cleveland, OH.
There is increasing evidence that transplanted adult stemcells remain undifferentiated and often are cleared after a short time.However, these short-lived stem cells still promote recovery…
2016 American Transplant Congress
The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.
C. Wang,¹ T. Xia,¹ X. Zhang,² K. Jiang,¹ J. Wang,¹ J. Nie.¹
¹Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China; ²Department of Integrative Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuahn, Hubei, China.
Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…
2016 American Transplant Congress
Dynamic Detection of Anti-HLA Antibodies Can Predict aGVHD and OS in HLA-12/12 Matched Unrelated-Donor Allo-HSCT for Hematological Malignancies.
J. He,¹ Z. Pan,¹ X. Yuan,¹ Y. Li,¹ X. Wu,² W. Zhu,² X. Bao,¹ Q. Zhao.²
¹Department of HLA Laboratory, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; ²Department of Hematology, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
The NMDP and CIBMTR provided guidelines for the use of anti-HLA antibodies in unrelated-donors hematopoietic stem cell transplantation (HSCT). However, a deeper understanding of other…
2016 American Transplant Congress
Ischemia-Reperfusion Injury Following Transplantation: Implications for the Modulation of CXCL8 Chemokine Function.
B. Martinez Burgo,¹ S. Ali,¹ J. Kirby,¹ N. Sheerin,¹ S. Cobb,² D. Kashanin.³
¹Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ²Chemistry Department, Durham University, Durham, United Kingdom; ³Cellix Ltd., Dublin, Ireland.
Ischemia-Reperfusion Injury (IRI) is a major contributor to subsequent graft dysfunction. Chemokines play a key role in leukocyte recruitment towards to the injured tissue. CXCL8…
2016 American Transplant Congress
Anti-HLA Antibodies in Allogeneic and Autologous Hematopoietic Stem Cell Transplantation.
A. Bertocchi, L. Requiao-Moura, M. Torres, E. Tonato, M. Durao Junior, A. de Matos, N. Hamershclak, A. Pacheco-Silva.
Kidney Transplantation, Hematology, Histocompatibility Laboratory, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Introduction: Anti-HLA antibodies have been associated with graft rejection in solid organ and hematopoietic stem cell transplantation (HSCT). The aim of this study was describe…
2016 American Transplant Congress
Seven Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
J. Leventhal,¹ J. Galvin,¹ D. Stare,¹ L. Gallon,¹ J. Miller,¹ J. Mathew,¹ M. Abecassis,¹ S. Ildstad.²
¹Northwestern University, Chicago; ²University of Louisville, Louisville.
36 subjects have been enrolled and 31 transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts…
2016 American Transplant Congress
Mesenchymal Stem Cells Reprogram Macrophage Polarization and Attenuate Liver Ischemia and Reperfusion Injury by Regulating Notch/Cox2/PGE2 Signaling Pathway.
C. Li,¹ S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ B. Ke.¹
¹The Dumont-UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Background and aims: Mesenchymal stem cells (MSCs) have been shown an immune modulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown…