ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Stem cells"

  • 2022 American Transplant Congress

    Apheresis of Deceased Donors: A New Source of Mobilized Peripheral Blood Hematopoietic Stem Cells for Transplant Tolerance

    R. A. Sosa1, T. Mone2, B. V. Naini1, D. B. Kohn3, E. F. Reed1, K. Wheeler2, B. Campo-Fernandez3, A. Davila3, D. J. Chaffin4, J. DiNorcia5, F. M. Kaldas5, A. Cohen2, E. Lum6, J. L. Veale7, N. M. Kogut7

    1Pathology and Lab Medicine, UCLA, Los Angeles, CA, 2One Legacy, Los Angeles, CA, 3Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, CA, 4LifeStream Blood Bank, San Bernadino, CA, 5Surgery, UCLA, Los Angeles, CA, 6Medicine, UCLA, Los Angeles, CA, 7Urology, UCLA, Los Angeles, CA

    *Purpose: Solid organ transplantation is the therapy of choice for many patients with end-stage organ failure, but recipients must remain on lifelong immune suppression, leaving…
  • 2022 American Transplant Congress

    Allogenic Cardiac Progenitor Cells Transplantation with Immune Suppressant Cyclosporine a Recovers Myocardial Infarction in Rodent Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Pediatrics, Lurie Childrens Hospital, Chicago, IL

    *Purpose: Cardiac progenitor cells (CPCs) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, auto and allo immune…
  • 2022 American Transplant Congress

    Cd47 Expression on Transplanted Human Neonatal Mesenchymal Stem Cells Inhibits Phagocytosis in Rat Myocardial Infarction Model

    M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, L. Chen, S. Guru, A. Stefanowicz, A. Bilewska, S. Zarinebaf, G. Zhi-Dong, S. Kaushal

    Lurie Childrens Hospital, Chicago, IL

    *Purpose: Immune rejection of transplanted stem/progenitor cells is a major stumbling block in designing effective therapy for myocardial infarction (MI). Human neonatal mesenchymal stem cells…
  • 2022 American Transplant Congress

    Achievement of Persistent Mixed Chimerism in Recipients of Matched and Mismatched Living Donor Kidney Transplants in a Tolerance Induction Protocol

    J. D. Scandling, S. Busque, R. Lowsky, T. Pham, R. Hoppe, K. Jensen, A. Shori, H. Wu, R. Pawar, E. Engleman, E. Meyer, S. Strober

    Stanford University School of Medicine, Stanford, CA

    *Purpose: The induction of tolerance to kidney transplants after development of specific unresponsiveness of recipient immune cells to donor alloantigens allows elimination of maintenance immunosuppressive…
  • 2022 American Transplant Congress

    Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice

    C. Little1, W. J. Haynes1, L. Huang1, C. Daffada1, K. B. Wolfe2, E. Perrin2, J. A. Simpson1, J. A. Kropp Schmidt2, H. M. Hinkle2, L. T. Keding2, R. T. Behrens2, D. T. Evans2, D. Kaufman1, J. A. Thomson2, T. G. Golos2, M. Brown1

    1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI

    *Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…
  • 2022 American Transplant Congress

    Human PBMC-Transferred Murine MHC Class I/II-Deficient NOG Mice Enable Long-Term Evaluation of Human Immune Responses to Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets

    R. Matsumoto

    Center for Immune Therapeutics and Diagnosis, Juntendo University, Tokyo, Japan

    *Purpose: Transplantation of cardiomyocytes sheets derived from allogenic human induced pluripotent stem cells (hiPS-CMs) hold great promise in generating new functional myocardium in situ. However,…
  • 2022 American Transplant Congress

    Plasma from Patients with Primary Focal Segmental Glomerulosclerosis Induce Development of Sclerotic Glomeruli in Kidney Organoids

    A. Kumar Gupta1, E. Minocha1, J. A. Wertheim1, L. Gallon2

    1Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 2Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: Primary focal segmental glomerulosclerosis (FSGS) is a kidney disorder resulting in end-stage renal disease that is associated with an elevated rate of recurrence after…
  • 2022 American Transplant Congress

    Experience with Covid-19 Infection and Vaccination in Combined Kidney/HSCT Recipients

    M. Gibson1, D. Belshe1, G. Gregory1, S. Tanna1, M. Ison1, S. Ildstad2, J. R. Leventhal1

    1Northwestern University, Chicago, IL, 2University of Louisville, Louisville, KY

    *Purpose: Kidney transplant(KTx) recipients are at increased risk of COVID-19 related complications. KTx pts who have undergone therapy to induce tolerance are a unique cohort…
  • 2022 American Transplant Congress

    Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells

    R. Chawangwongsanukun1, R. Lathan1, R. Pearson2, M. Clancy2, P. Mark1

    1Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, 2Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom

    *Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
  • 2022 American Transplant Congress

    Adoptive Transfer OfMesenchymal Stem Cells Activates Hedgehog/SMO/Gli1 Signaling And Inhibits STING-mediated Innate Immune Response In Liver Transplant Inflammatory Injury

    D. Xu1, X. Qu1, Y. Tian1, M. Sheng1, Y. Lin1, Y. Zhan1, F. M. Kaldas1, R. W. Busuttil1, D. G. Farmer1, J. W. Kupiec-Weglinski1, Q. Xia2, B. Ke1

    1Surgery, Dumont - UCLA Transplant Ctr, Los Angeles, CA, 2Liver Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, China

    *Purpose: The stimulator of interferon genes (STING) pathway has been recognized as a crucial signaling cascade of the innate immune system. Activation of the Hedgehog…
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