2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…2017 American Transplant Congress
Short-Term Combination Treatment of FK506 and Anti-CD40 Ligand Remarkably Prolong Allograft Survival Time in Mouse Skin Transplantation.
Background: It is well established that skin are more prone than kidney to rejection after transplantation and is difficult to archive allograft acceptance following normal…2016 American Transplant Congress
The Role and Mechanism of CD40/CD40L Expression on Different T-Cell Subsets.
Background: Several T-cell costimulatory pathways (i.e. CD28:B7 and CD40:CD40L) play a critical role in modulating alloreactivity, but their function on distinct T cell subsets remains…2016 American Transplant Congress
Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?
Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Solution for Ex Vivo Preservation in Vascularized Composite Allotransplantation (VCA).
University of Pittsburgh, Pittsburgh.
Background: Improved preservation techniques could reduce ischemia-reperfusion injuries (IRI) and allow better matching and allocation of VCA grafts across wider distances. A novel SNMP system…2016 American Transplant Congress
Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.
Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…2016 American Transplant Congress
Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.
Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…2016 American Transplant Congress
Aging Is Critically Impacting the Efficacy of Immunosuppressants.
Immunosenescence is broadly affecting alloimmunity with major implications on immunosuppression. Older recipients have thus far been mostly excluded from clinical trials. Here, we dissected the…2016 American Transplant Congress
An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.
Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…2016 American Transplant Congress
Systematic Pathological Component Scores for Skin-Containing Vascularized Composite Allografts.
Successful application of skin-containing vascularized composite allografts (VCA) depends on accurate assessment of the graft status typically based on skin biopsies. A working classification (Banff…
- « Previous Page
- 1
- …
- 3
- 4
- 5
- 6
- Next Page »