ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Skin transplantation"

  • 2017 American Transplant Congress

    Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.

    T. Win,1 B. Dyring-Andersen,1 V. Barrera,2 S. Ho Sui,2 R. Lopdrup,1 H. Kiwanuka,1 N. Murakami,1 J. Teague,1 E. Lowry,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston

    BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…
  • 2017 American Transplant Congress

    2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.

    S. Laurie, D. Liu, M. Cortes, M. Wagener, M. Ford.

    Emory Transplant Center, Atlanta, GA

    Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…
  • 2016 American Transplant Congress

    The Role and Mechanism of CD40/CD40L Expression on Different T-Cell Subsets.

    N. Granofszky, K. Hock, B. Mahr, N. Pilat-Michalek, T. Wekerle.

    Department of Surgery, Section of Transplantation Immunology, Medical University of Vienna, Vienna, Austria.

    Background: Several T-cell costimulatory pathways (i.e. CD28:B7 and CD40:CD40L) play a critical role in modulating alloreactivity, but their function on distinct T cell subsets remains…
  • 2016 American Transplant Congress

    Skin as a Harbinger of Rejection of Underlying Structures in Vascularized Composite Allografts: Concordance or Discordance?

    L. Cendales,1 M. Levine,2 S. Bartlett,3 J. Cheeseman,1 C. Drachenberg,3 W. Hancock,4 M. Joshi,1 A. Kirk,1 F. Leoopardi,1 S. Levin,2 M. Uluer,3 A. Selim,5 M. Song,1 W. Twaddell,3 L. Wang,4 Z. Wang,2 R. Barth.3

    1Surgery, Duke University, Durham, NC; 2University of Pennsylvania, Philadelphia, PA; 3University of Maryland School of Medicine, Baltimore, MD; 4Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; 5Pathology, Duke University, Durham, NC.

    Vascularized composite allografts (VCA) are composed of multiple tissue types. It has not been determined as to whether there is an immune hierarchy or differential…
  • 2016 American Transplant Congress

    Subnormothermic Machine Perfusion (SNMP) with a Novel Hemoglobin-Based Oxygen Carrier (HBOC) Solution for Ex Vivo Preservation in Vascularized Composite Allotransplantation (VCA).

    S. Oksuz, R. Schweizer, M. Minervini, B. Banan, V. Gorantla, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Background: Improved preservation techniques could reduce ischemia-reperfusion injuries (IRI) and allow better matching and allocation of VCA grafts across wider distances. A novel SNMP system…
  • 2016 American Transplant Congress

    Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.

    L. Margoles, S. Laurie, C. Coopersmith, M. Ford.

    Emory Transplant Center, Department of Surgery, Emory University, Atlanta, GA.

    Concurrent infections have been shown to increase risk of transplant rejection via enhanced innate immune activation and increased T cell alloreactivity. In some cases, these…
  • 2016 American Transplant Congress

    Heat Shock Protein 90 Inhibitor 17DMAG Is a Potential New Therapeutic Agent Against Acute Allograft Rejection.

    T. Maehana,1 T. Tanaka,1 H. Kitamura,2 N. Masumori.1

    1Urology, Sapporo Medical University School of Medicine, Sapporo, Japan; 2Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.

    Purpose: We have previously demonstrated that Heat shock protein 90 (HSP90) plays a role in the development of acute rejection (AR) in organ transplantation. To…
  • 2016 American Transplant Congress

    Aging Is Critically Impacting the Efficacy of Immunosuppressants.

    J. Schuitenmaker, K. Edtinger, M. Seyda, H. Uehara, M. Quante, A. ElKhal, S. Tullius.

    Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Immunosenescence is broadly affecting alloimmunity with major implications on immunosuppression. Older recipients have thus far been mostly excluded from clinical trials. Here, we dissected the…
  • 2016 American Transplant Congress

    An In-Situ Treatment of Donor Skin Induces MARCH1 and Decreases MHC II Expression on Donor Dendritic Cells, Promoting Skin Allograft Acceptance.

    T. Borges,1,2 F. Machado,1 C. Bonorino,1 L. Riella.2

    1School of Biosciences and Biomedical Research Institute, PUCRS, Porto Alegre, RS, Brazil; 2Schuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

    Background: Skin transplants are the most immunogenic of all transplants and donor DCs play a crucial role in activating effector alloreactive T cells and initiating…
  • 2016 American Transplant Congress

    Systematic Pathological Component Scores for Skin-Containing Vascularized Composite Allografts.

    I. Rosales,1 M. DeFazio,2 R. Foreman,1 D. Sachs,2 C. Cetrulo,2 D. Leonard,2,3 R. Colvin.1

    1Pathology, Massachusetts General Hospital, Boston; 2Transplantation Biology Research Center, Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston; 3Plastic and Reconstructive Surgery, Countess of Chester Hospital, Chester, United Kingdom.

    Successful application of skin-containing vascularized composite allografts (VCA) depends on accurate assessment of the graft status typically based on skin biopsies. A working classification (Banff…
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