2017 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2017 American Transplant Congress
Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism.
Massachusetts General Hospital, Boston, MA
PURPOSE: Donor bone marrow transplantation (DBMT) has been investigated in experimental and clinical vascularized composite allotransplantation (VCA). With longer-term follow-up, reports of chronic VCA rejection…2017 American Transplant Congress
Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.
1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston
BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…2017 American Transplant Congress
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity.
Emory Transplant Center, Atlanta, GA
Current thinking holds that costimulation-blockade resistant graft rejection may be mediated by CD28null T cells. To further investigate this possibility, we performed a retrospective immunophenotypic…2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…2017 American Transplant Congress
Donor Batf3-Dependent Dendritic Cells Initiate Acute Rejection in a Skin Transplantation Model.
Donor skin dendritic cells (DCs) play a crucial role in providing allospecific signal to host T cells either by direct interaction of donor MHC with…2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…2017 American Transplant Congress
Short-Term Combination Treatment of FK506 and Anti-CD40 Ligand Remarkably Prolong Allograft Survival Time in Mouse Skin Transplantation.
Background: It is well established that skin are more prone than kidney to rejection after transplantation and is difficult to archive allograft acceptance following normal…2017 American Transplant Congress
A Novel Microsurgical Penis Transplant Model to Study Distinct Immunologic Features of Urogenital Tissues.
Johns Hopkins University, Baltimore, MD
Background: Penis transplantation has been successfully employed in the recent past and represents an exciting avenue for restoration of male urogenitalia and function by using…2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
American Transplant Congress abstracts