2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…2019 American Transplant Congress
Effect of Chronic Kidney Disease on Allo-Immune Response in Mice
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). However, mouse models…2019 American Transplant Congress
Increasing Expression of B-cell Maturation Antigen during the Development of Recall Antibody Responses: A Prospective Pharmaceutical Target for B-cell Suppression?
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Our previous study found that B cell maturation antigen (BCMA) is increasingly expressed by B/plasma cells during the development of de novo alloantibody responses.…2019 American Transplant Congress
Facial Composite Tissue Allotransplantation: First Canadian Experience
1Hopital Maisonneuve-Rosemont, Montreal, QC, Canada, 2University of Montreal, Montreal, QC, Canada
*Purpose: Facial vascularized composite allotransplantation (VCA) has emerged as a groundbreaking reconstructive solution for patients with severely disfiguring facial injuries. It allows simultaneous “like with…2018 American Transplant Congress
Glycolytic Bias in mTORC2-Deficient Dendritic Cells Potentiates Antigen-Specific Immunity and Accelerates Graft Rejection
The mechanistic target of rapamycin (mTOR) is known to function in two complexes: mTOR complex 1 (mTORC1) and mTORC2. While the function of mTORC1 in…2018 American Transplant Congress
Origin and Traffic of Donor-Derived Extracellular Vesicles during Allo-Sensitization
The idea that donor dendritic cells (DCs) transplanted with the grafts and mobilized to draining lymphoid tissues (dLTs) present donor MHC molecules to allo-reactive naïve…2018 American Transplant Congress
Donor Bone Marrow CXCR4+ Foxp3+ Treg Cells Are Essential for Costimulation Blockade-Induced Long-Term Survival of Murine Limb Transplants
1CHOP, Philadelphia; 2UPenn, Philadelphia.
Vascularized composite allotransplantation (VCA) would likely be more widely performed if maintenance immunosuppression was not essential for graft acceptance. Accordingly, we used murine models of…2018 American Transplant Congress
Achieving Allograft Tolerance through Antigen-Specific Regulatory B Cells
IntroductionA complete understanding of the role of antigen-specificity in the development of B cell mediated allograft tolerance has remained elusive. Previous work in our lab…2018 American Transplant Congress
LAG-3 Deletion Upregulates Memory in a Dendritic Cell-Dependent Process
Introduction. Cardiac transplantation is critical for management of severe heart failure, but cardiac allografts frequently undergo chronic T-cell-mediated allograft rejection. Our research demonstrates that Lymphocyte…2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…
American Transplant Congress abstracts