Articles tagged "Renal function"

2020 American Transplant Congress
Envarsus XR Use Can Benefit Serum Creatinine Levels in Vascularized Composite Allotransplantation Patients
C. M. Cooney¹, V. Javia¹, J. Littleton¹, D. S. Cooney¹, R. J. Redett¹, J. T. Shores¹, D. C. Brennan², G. Brandacher¹
¹Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Vascularized composite allotransplantation (VCA) is a life-enhancing (as opposed to life-saving) procedure. Therefore, minimizing adverse outcomes associated with chronic immunosuppression is vital to determining…
2019 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification
M. Raynaud¹, O. Aubert¹, M. Naesens², I. Juric³, N. Basic³, N. Kamar⁴, E. Huang⁵, S. Jordan⁵, B. Orandi⁶, D. Segev⁶, M. Stegall⁷, E. Morelon⁸, M. Giral⁹, E. Bailly¹⁰, E. Akalin¹¹, G. Gupta¹², M. Ladrière¹³, M. Buchler¹⁰, P. Reese¹⁴, C. Lefaucheur¹, A. Loupy¹
¹Paris, ., France, ²Leuven, ., Belgium, ³Zagreb, ., Croatia, ⁴Toulouse, ., France, ⁵Los Angeles, ., CA, ⁶Baltimore, ., MD, ⁷Rochester, ., MN, ⁸Lyon, ., France, ⁹Nantes, ., France, ¹⁰Tours, ., France, ¹¹New York, ., NY, ¹²Richmond, ., VA, ¹³Nancy, ., France, ¹⁴Philadelphia, ., PA
*Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…
2019 American Transplant Congress
Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation
L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…
2019 American Transplant Congress
Usefulness of the Assessment of CT-Based Donor Kidney Function Compared with Radionuclide Scintigraphy
K. Park, J. Yoon, H. Kim, C. Baek, S. Park, H. Kim
Division of Nephrology, Department of Internal Medicine, Asan Medical Center, SEOUL, Korea, Republic of
*Purpose: Pretransplant graft volume and function has been demonstrated to be an important factor in subsequent allograft outcomes. Most transplant centers underwent renal split function…
2019 American Transplant Congress
Early Pancreas Loss in Simultaneous Pancreas Kidney Transplants: Does It Matter for the Kidney?
D. Das, J. Huskey, R. Heilman, K. S. Reddy, A. Moss, J. Harbell, C. Jadlowiec
Mayo Clinic AZ, Phoenix, AZ
*Purpose: Surgical and immunosuppressive refinements have led to improved outcomes in simultaneous pancreas-kidney (SPK) transplants. Despite these improvements, early pancreas allograft loss remains not insignificant.…
2019 American Transplant Congress
Efficacy and Safety Outcomes with De Novo Use of Everolimus-Based Regimen in Renal Transplant Recipients with Delayed Graft Function from the TRANSFORM Study
S. Chadban¹, F. Oppenheimer¹, F. Citterio¹, O. Witzke¹, V. D. Garcia¹, A. Gutierrez-Dalmau¹, P. Narvekar², M. P. Hernandez Gutierrez², P. Bernhardt², A. Wiseman¹
¹TRANSFORM Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To evaluate the effect of everolimus with reduced CNI (EVR+rCNI) vs mycophenolic acid with standard CNI (MPA+sCNI) on efficacy and safety outcomes in RTxR…
2019 American Transplant Congress
High Urinary Neutrophil Gelatinase Lipocalins (NGAL) Levels in Kidney Perfusates as Predictor of a Better Renal Function
A. Angeletti, C. Donadei, V. De Pace, I. Capelli, V. Corradetti, C. Zannini, F. Alviano, L. Bonsi, G. Comai, M. Ravaioli, G. La Manna
DIMES, S.Orsola-Malpighi Hospital, Bologna University, Bologna, Italy
*Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) has recently emerged as a biomarker of different conditions, but the biological role remains unclear. We hypnotized that NGAL has…
2019 American Transplant Congress
The Kidney Donor Profile Index (KDPI) Predicts the Risk of Graft Loss in Patients with a Kidney Transplant from Maastricht Type III Asystolic Donors
V. Lopez Jimenez, C. Casas, P. Ruiz-Esteban, M. Cabello, E. Sola, P. Hidalgo, J. Alonso, M. González-Molina, D. Hernandez
Nephrology, H.R.U Carlos Haya, Málaga, Spain
*Purpose: Recent years have seen an increase in the number of kidney transplants (KT) from Maastricht type III asystolic donors, resulting in the acceptance criteria…
2019 American Transplant Congress
The Influential Yet Highly Variable Role of Biopsy Findings on Kidney Offer Acceptance Decisions: An Organ Offer Simulation Study
D. Stewart¹, J. Rosendale¹, H. McGehee¹, I. Hall², G. Gupta³, K. Reddy⁴, B. Kasiske⁵, K. Andreoni⁶, D. Klassen¹
¹UNOS, Richmond, VA, ²Univ of Utah, Salt Lake City, UT, ³VCU, Richmond, VA, ⁴Mayo, Phoenix, AZ, ⁵HCMC, Minneapolis, MN, ⁶Univ of Florida, Gainesville, FL
*Purpose: The use of procurement biopsies (Bx) to assess kidney quality is controversial. ‘Biopsy findings’ is an often cited discard reason, yet the association between…
2019 American Transplant Congress
Effect of Everolimus with Reduced-Exposure Tacrolimus and Early Steroid Elimination in Pediatric Kidney Transplant Recipients: 36-Month Outcomes from the CRADLE Study
H. Tedesco Silva¹, R. Ettenger¹, A. Bjerre¹, M. Christian¹, L. Dello Strologo¹, S. D. Marks¹, L. Pape¹, P. Lopez², M. Cousin², P. Pandey², B. Rauer², M. Meier², B. Tönshoff¹
¹A2314 Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To compare 36-month (M) efficacy and safety outcomes of an everolimus+reduced-exposure tacrolimus (EVR+rTAC)+steroids (CS) withdrawal regimen vs mycophenolate mofetil+standard-exposure TAC (MMF+sTAC)+CS in pediatric kidney…

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