Articles tagged "Renal function"

2018 American Transplant Congress
Efficacy and Safety of Tocilizumab in Treatment of Acute Antibody Mediated Rejection
K. Venkatachalam, D. Reem, M. Andrew, R. Delos Santos, T. Alhamad.
Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Ohio State University, Columbus, OH; Transplant Nephrology, Washington University, Saint Louis, MO; Transplant Nephrology, Washington University, Saint Louis, MO.
Antibody mediated rejection continues to be one of the most detrimental complications of kidney transplant. Multiple therapeutic strategies focused on B cell and/or HLA antibody…
2018 American Transplant Congress
Side Effect Profile of Everolimus in Liver Transplant Patients
F. Kumssa, O. Sadiq, M. Alimirah, R. Kaur, A. Patel, S-.M. Jafri.
Henry Ford Hospital, Detroit.
IntroductionUse of calcineurin inhibitors has been the mainstay of antirejection medications after liver transplant (LT). However, renal toxicity from these drugs remains troublesome. By comparison,…
2018 American Transplant Congress
Kidney Transplantation in ESKD Patients with a History of Sickle Cell Disease/Trait
A. Lee, G. Malat, M. Harhay, L. Levin, G. Xiao, S. Guy, D. Reich, K. Ranganna.
Department of Medicine, Division of Nephrology & Hypertension, Drexel University College of Medicine, Philadelphia, PA.
Introduction:Kidney transplantation in Sickle Cell Disease patients is fraught with complications, including increased risk of infection and thrombosis. We present long term outcomes of patients…
2018 American Transplant Congress
Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients
A. Lichvar,¹ S. Tremblay,² D. Naik,² E. King,⁴ A. Vinks,⁴ U. Christians,³ J. Lipscomb,⁴ R. Alloway.²
¹U of Illinois at Chicago, Chicago, IL; ²U of Cincinnati, Cincinnati, OH; ³U of Colorado, Denver, CO; ⁴Cincinnati Children's, Cincinnati, OH.
Background: Long-term studies with control groups are required to assess tacrolimus (TAC) conversion. The purpose of this study was to compare clinical and safety outcomes…
2018 American Transplant Congress
Renal-Sparing Protocol May Be Harmful If Performed Early Post-Heart Transplant
J. Patel, M. Johl, E. Kransdorf, M. Kittleson, S. Dimbil, R. Levine, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Calcineurin inhibitors (CNIs) are associated with nephrotoxicity. Renal sparing protocol (RSP) with CNI free regimen using mycophenolate and a proliferation signal inhibitor may improve…
2018 American Transplant Congress
Comparison of Temperatures for Optimal Preservation of Donor Kidneys during Oxygenated Pulsatile Perfusion
R. Bhattacharjee,¹ M. Richard-Mohamed,² A. Ruthirakanthan,³ R. Mayer,² S. Luke,³ H. Sharma,² M. TunAbraham,² B. Alharbi,² A. Haig,² P. Luke.^1,2,3
¹Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Western University, Canada, London, ON, Canada.
Background. The current methods of preserving DCD renal allografts in either static cold solution or hypothermic pulsatile perfusion are unable to adequately protect the kidney…
2018 American Transplant Congress
The Renal Sparing Protocol after Heart Transplant That Keeps Giving
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, R. Sharoff, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Calcineurin inhibitors (CNI) such as cyclosporine and tacrolimus are known to cause chronic renal failure. As a result, programs have developed renal-sparing protocols (RSP)…
2018 American Transplant Congress
Change in Estimated Glomerular Filtration Rate Pre and Post Development of Donor-Specific Antibodies after Kidney Transplantation
B. Ho,¹ S. Montag,^1,2 H. Bhagat,³ K. Atiemo,¹ A. Daud,¹ R. Kang,¹ L. Zhao,^1,2 J. Schwartz,³ D. Ladner.¹
¹Northwestern University Transplant and Outcomes Research Collaborative (NUTORC), Chicago; ²Dept of Preventive Medicine, Northwestern University, Chicago; ³Astellas Pharma Global Development, Inc., Northbrook.
Formation of de novo donor-specific antibodies (dnDSA) against human leukocyte antigens contributes to inferior kidney transplant (KT) outcomes. We assessed the effect of dnDSA on…
2018 American Transplant Congress
Quantification of the Indirect Effect of Recipient Characteristics on Kidney Graft Function
S. Rao,¹ A. Gillespie,¹ J. Lee,¹ K. Lau,² S. Karhadkar,² A. Di Carlo,² S. Constantinescu.¹
¹Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA; ²Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Recipient characteristics play an important role for donor selection in deceased donor kidney transplant recipients (DDKT). The current kidney allocation system (KAS) for deceased donors…
2018 American Transplant Congress
Urinary Sulfate Excretion and Late Graft Failure in Renal Transplant Recipients
M. Said,¹ A. Post,¹ I. Minovic,¹ M. van Londen,¹ H. van Goor,² D. Postmus,³ M. Heiner-Fokkema,⁴ E. van den Berg,¹ A. Pasch,⁵ G. Navis,¹ S. Bakker.¹
¹Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; ²Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands; ³Department of Epidemiology, University of Groningen, Groningen, Netherlands; ⁴Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Biomedical Research, University of Bern, Bern, Switzerland.
BackgroundHydrogen sulfide (H2S), produced from the metabolism of dietary sulfur-containing amino acids, is allegedly a potential renoprotective compound. High 24h urinary excretion of pathway intermediate…