Articles tagged "Renal function"

2019 American Transplant Congress
Long Term Outcomes in Kidney Transplant Recipients Receiving Everolimus (EVR) or Mycophenolate (MPS) in Combination with Tacrolimus (TAC)
K. Ficher, C. Rosso Felipe, Y. Cardoso Dreige, K. Linhares, A. Ferreira Brígido, S. Stopa, L. Viana, M. Cristelli, P. Gessolo Lins, W. Aguiar, H. Proença, R. Marco, M. Gerbase de Lima, H. Tedesco Silva Junior, J. Medina Pestana
Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil
*Purpose: Detailed long-term data comparing the use of EVR or MPS in kidney transplant recipients receiving TAC is lacking.*Methods: This is a 5-years extension analysis…
2019 American Transplant Congress
Deficiency of IRE1a Ameliorates Renal Allograft Injury via Remodeling of Graft-Infiltrating Macrophages
L. Qiu¹, J. Wang¹, X. Yeap¹, S. Han¹, F. Zheng¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Inflammatory macrophages contribute to the development of ischemia-reperfusion injury (IRI) and allograft rejection. However, the underlying mechanisms by which macrophage mediate allograft injury and…
2018 American Transplant Congress
Quantification of the Indirect Effect of Recipient Characteristics on Kidney Graft Function
S. Rao,¹ A. Gillespie,¹ J. Lee,¹ K. Lau,² S. Karhadkar,² A. Di Carlo,² S. Constantinescu.¹
¹Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA; ²Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
Recipient characteristics play an important role for donor selection in deceased donor kidney transplant recipients (DDKT). The current kidney allocation system (KAS) for deceased donors…
2018 American Transplant Congress
Urinary Sulfate Excretion and Late Graft Failure in Renal Transplant Recipients
M. Said,¹ A. Post,¹ I. Minovic,¹ M. van Londen,¹ H. van Goor,² D. Postmus,³ M. Heiner-Fokkema,⁴ E. van den Berg,¹ A. Pasch,⁵ G. Navis,¹ S. Bakker.¹
¹Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; ²Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands; ³Department of Epidemiology, University of Groningen, Groningen, Netherlands; ⁴Department of Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands; ⁵Department of Biomedical Research, University of Bern, Bern, Switzerland.
BackgroundHydrogen sulfide (H2S), produced from the metabolism of dietary sulfur-containing amino acids, is allegedly a potential renoprotective compound. High 24h urinary excretion of pathway intermediate…
2018 American Transplant Congress
Radioisotopic Evaluation of Glomerular Filtration Rate (GFR) before and 1 Year after Kindey Donation for Transplantation: The Concept of Estimated Renal Functional Reserve (eRFR)
V. Cantaluppi,¹ G. Guglielmetti,¹ M. Mora,¹ A. Airoldi,¹ F. Orsini,² M. Quaglia,¹ G. Sacchetti,² C. Ronco.³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy; ²Nuclear Medicine Unit, Maggiore della Carità University Hospital, Novara, Italy; ³Nephrology, Dialysis and Kidney Transplantation Unit, International Renal Research Institute (IRRIV), Vicenza, Italy.
Kidney donors (KD) develop a partial loss of renal function defined as Acute Kidney Injury (AKI). Recovery from AKI is due to renal functional reserve…
2018 American Transplant Congress
Antiproteinuric Effect of Spironolactone in Renal Transplantation: Effectiveness and Clinical Outcomes
M. Sousa, C. Do Valle, G. Rivelli, L. Camargo, R. Zollner, M. Mazzali.
University of Campinas, Campinas, Sao Paulo, Brazil.
Background: aldosterone is involved in development of fibrosis in kidney transplantation. Blockade of aldosterone receptor appears to be effective in treatment for chronic allograft dysfunction,…
2018 American Transplant Congress
Long-Term Effect of BMI on Renal Function in Asian Living Kidney Donors
J. Na,¹ J. Park,¹ M-.G. Yoon,¹ H. Lee,² Y. Yoon,³ K. Huh,⁴ M. Kim,⁴ S. Kim,⁴ Y. Kim,⁴ W. Han.¹
¹Department of Urology, Yonsei University College of Medicine, Urological Science Institute, Seoul, Korea; ²Department of Urology, National Health Insurance Service Ilsan Hospital, Goyang-si, Korea; ³Department of Urology, Hanyang University Medical Center, Seoul, Korea; ⁴Department of Surgery-Transplantation, Yonsei University College of Medicine, Seoul, Korea.
One of the targets of expanding criteria for kidney donation is BMI. As the impact of BMI differs in Asians, we studied the long-term effect…
2018 American Transplant Congress
Histogenomics: Molecular Profiling of Kidney Biopsies Predict Delayed Graft Function
P. Rao,¹ D. Deo,¹ B. Fyfe-Kirschner,² R. Siderits.²
¹NJ Sharing Network, New Providence, NJ; ²Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
IntroductionHistologic assessments of donor renal biopsies for percentage global glomerulosclerosis, interstitial fibrosis and arterial sclerosis can predict renal graft failure post-transplant.The morphologic evaluation of renal…
2018 American Transplant Congress
Superiority of Early Everolimus-Based Quadruple Immunosuppression versus Standard Triple Therapy after Lung Transplantation: 12 Months Results from Prospective 4EVERLUNG Study in Germany
J. Gottlieb, C. Neurohr, J. Müller-Quernheim, H. Wirtz, B. Sill, H. Wilkens, V. Besa, C. Knosalla, M. Junge, C. Capusan, M. Strüber.
Klinik, Hannover, Germany; Klinik, München, Germany; Klinik, Freiburg, Germany; Klinik, Leipzig, Germany; Klinik, Hamburg, Germany; Klinik, Homburg, Germany; Klinik, Essen, Germany; Klinik, Berlin, Germany; Novartis Pharma, Nürnberg, Germany; Novartis Pharma, Nürnberg, Germany; Klinik, Hannover, Germany.
The 4Everlung trial was designed to evaluate the benefit of early everolimus (EVR)-based quadruple low immunosuppressive (IS) regimen on kidney function (RF) after LTx.4EVERLUNG is…
2018 American Transplant Congress
Long-Term Follow Up of Living Kidney Donors with CKD at 1 Year after Nephrectomy
J. Na,¹ J. Park,¹ M-.G. Yoon,¹ H. Lee,² Y. Yoon,³ K. Huh,⁴ M. Kim,⁴ S. Kim,⁴ Y. Kim,⁴ W. Han.¹
¹Department of Urology, Yonsei University College of Medicine, Urological Science Institute, Seoul, Korea; ²Department of Urology, National Health Insurance Service Ilsan Hospital, Goyang-si, Korea; ³Department of Urology, Hanyang University Medical Center, Seoul, Korea; ⁴Department of Surgery-Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Introduction:Many kidney donors show poor recovery after donation and the long-term prognosis of those patients has not been well studied. In this study we explored…