Articles tagged "Renal dysfunction"

2022 American Transplant Congress
Meta-Analysis of the Chronic Exposure to Calcineurin Inhibitors and the Risk for Chronic and End-Stage Kidney Disease in Non-Renal Solid Organ Transplant Recipients
A. Alvarez Elias¹, M. Riedl¹, D. Stewart², A. Ruco³, P. Bobos³, S. Maharaj⁴, V. Shah⁵, E. Uleryk⁶, C. Teoh¹, R. Parekh¹
¹Hospital for Sick Children, Toronto, ON, Canada, ²Royal Hospital for Children, Glasgow, United Kingdom, ³St. Michael’s Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Mount Sinai Hospital, Toronto, ON, Canada, ⁶E. M. Uleryk Consulting, Toronto, ON, Canada
*Purpose: Calcineurin inhibitors (CNI) are standard of care immunosuppressants among all solid organ transplant (SOT) recipients, and the most common side effect is nephrotoxicity. There…
2022 American Transplant Congress
Re-Examining the Optimal Threshold for Donor Derived Cell Free DNA in Renal Allograft Rejection
H. Murad¹, M. Merzkani¹, M. Ji¹, S. Chang¹, A. Malone¹, R. Delos Santos¹, T. Alhamad²
¹Washington University in St. Louis, St Louis, MO, ²Washington University in St. Louis, Saint Louis, MO
*Purpose: Due to the invasive nature and potential complications of allograft biopsies, there is an important role for surrogate biomarkers to help identify rejection early,…
2022 American Transplant Congress
Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection
H. BAE¹, J. Ryu², J. Jang¹, J. Lee¹, G. Ko¹, H. PARK¹, E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Laboratory Medicine, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, seoul, Korea, Republic of, ³Catholic University Department of Laboratory Medicine, Seoul 137-040, Korea, Republic of
*Purpose: BK virus (BKV) infection is a common problem in kidney transplant recipients receiving immunosuppressive therapy, resulting in a serious complications including BKV-associated nephropathy and…
2022 American Transplant Congress
Steatosis Following Liver Transplantation for Nonalcoholic Steatohepatitis is Associated with a Higher Rate of Cardiovascular Complications
W. Alhamoudi¹, S. Alqahtani², K. Bzeizi², A. Albenmousa², Y. Saleh², D. Broering², S. Alghamdi²
¹Medicine, King Saud University, Riyadh, Saudi Arabia, ²Liver Transplantation, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
*Purpose: Cirrhosis secondary to Nonalcoholic Steatohepatitis (NASH) is projected to become the leading indication for liver transplantation (LT) worldwide. Objectives: to evaluate the prevalence of…
2021 American Transplant Congress
Assessing the Impact of Acute Major Adverse Kidney Events on Clinical Outcomes in Heart Transplant Recipients
J. E. Kelly¹, C. Perez¹, D. Taber¹, R. J. Tedford², B. McMahon², S. Alzaidi¹, H. B. Meadows¹
¹Pharmacy, MUSC Health, Charleston, SC, ²Medicine, MUSC Health, Charleston, SC
*Purpose: The purpose of this study was to elucidate contributors to the Major Adverse Kidney Events at 30 days (MAKE-30) outcome in heart transplant recipients…
2021 American Transplant Congress
Pre Transplant Estimated Glomerular Filtration Rate and Other Predictors of Mortality and End Stage Kidney Disease After Lung Transplantation
A. Kumar¹, L. N. Bonnell², C. Thomas³
¹Internal Medicine, University of Vermont, Burlington, VT, ²Department of General Internal Medicine Research, University of Vermont, Burlington, VT, ³Internal Medicine, University of Iowa, Iowa City, IA
*Purpose: Lung transplantation is an established treatment for end stage lung disease and as survival has improved, chronic kidney disease (CKD) has become a common…
2021 American Transplant Congress
The Trifecta Study: Calibrating Circulating Donor-Derived Cell-Free DNA at the Time of Indication Biopsies Against the Molecular Phenotype of the Biopsy Reveals a Prominent Association with NK Cell Genes
P. Halloran¹, Z. Demko², A. Prewett², J. Reeve¹, P. Billings²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²Natera Inc., San Carlos, CA
*Purpose: The international, multicenter, prospective Trifecta study was designed to calibrate dd-cfDNA% measurements in blood at the time of indication biopsy against the molecular characteristics…
2021 American Transplant Congress
Renal Tubular-cell-specific Urinary Extracellular Vesicles: A Novel Biomarker for Diabetic Nephropathy After Kidney Transplantation
N. Eguchi¹, H. Lau¹, F. Zaldivar², U. G. Reddy³, E. Tantisattamo³, A. Ferrey³, D. Dafoe¹, H. Ichii¹
¹Surgery, University of California Irvine, Orange, CA, ²Pediatric Execise and Genomics Research Center, University of California Irvine, Irvine, CA, ³Medicine, University of California Irvine, Orange, CA
*Purpose: Diabetes(DM) is a leading cause of ESRD among renal transplant recipients(RTRs). However, the kinetics of diabetic nephropathy recurrence after renal transplantation(RT) remains unclear. Currently,…
2021 American Transplant Congress
Clinical Effect of Post-transplant Av-fistula Ligation on Hemodynamic Status and Kidney Allograft Function
S. Valavoor, J. Powelson, A. Sharfuddin, O. Adebiyi
Nephrology, Indiana University, Indianapolis, IN
*Purpose: Ligation of AVF post kidney transplant often done mostly for esthetic reasons, however, they are occasionally indicated in the presence severe steal syndrome, severe…
2021 American Transplant Congress
The Association of Pre-Kidney Transplant C-Peptide Level with Post Transplant Outcomes
A. J. Vinson, K. Tennankore
Nova Scotia Health Authority Division of Nephrology, Departm, Halifax, NS, Canada
*Purpose: Insulin is produced by pancreatic beta-cells by cleavage of a prohormone precursor into equal parts insulin and C-peptide. C-peptide has been shown to have…