Articles tagged "Rejection"

2018 American Transplant Congress
Isolation and Profiling of miRNAs from Formalin Fixed Paraffin Embedded Endomyocardial Tissues from Human Heart Transplant Recipients
R. Nog,^1,2 C. Gupta,^1,2 J. Fallon,^1,2 J. Panza,^1,2 N. Haque.²
¹Westchester Medical Center, Valhalla, NY; ²New York Medical College, Valhalla, NY.
Allograft rejection is a common complication post heart transplant (HTx) and can be confirmed by endomyocardial biopsy (EBx) only. There is however an increasing need…
2018 American Transplant Congress
Comparison of Bortezomib in Addition to Rituximab Based Treatment of Acute Antibody Mediated Rejection in Kidney Transplantation
A. Mattiazzi,^1,2 J. Pagan,^1,2 A. Arunachalam,¹ I. De la Cruz Alcantara,¹ J. Revollo,² A. Centeno,² A. Valdes,^1,2 G. Guerra.^1,2
¹Nephrology & Hypertension, University of Miami, Miami, FL; ²Miami Transplant Institute, Jackson Memorial Hospital, Miami, FL.
Purpose:The optimal treatment strategy of acute antibody mediated rejection (AMR) in renal allograft recipients remains undefined. The aim of our study was to compare the…
2018 American Transplant Congress
Magnitude of Pre-Biopsy Decline in Renal Function and Its Association with Allograft Rejection
S. Voora,¹ P. Ahearn,¹ M. Tavakol,² K. Johansen,^1,3 E. Ku.¹
¹Division of Nephrology, UCSF, San Francisco, CA; ²Department of Surgery, UCSF, San Francisco, CA; ³Department of Epidemiology/Biostatistics, UCSF, San Francisco, CA.
Introduction: Acute rejection is a significant cause of morbidity, and transplant biopsy remains the gold standard for diagnosing rejection. To our knowledge there have been…
2018 American Transplant Congress
Metabolic Regulation of Neuropeptides Induces Weight Loss and is Linked to Prolongation of Allograft Survival
M. Quante,^1,2 T. Heinbokel,¹ K. Minami,¹ Y. Nian,¹ A. Elkhal,¹ S. Tullius.¹
¹Transplant Surgery Research Lab, Brigham and Women's Hospital, Boston, MA; ²Department of General, Visceral and Transplant Surgery, Tuebingen Unversity Hospital, Tuebingen, Germany.
Obesity has become a common comorbidity among transplant recipients that is linked to inferior transplant outcome through far-reaching effects on metabolism, inflammation and immunity. Increasingly,…
2018 American Transplant Congress
The Influence of Rabbit Antithymocyte Globulin (rATG) Dose on the Incidence of CMV Infection in Kidney Transplant Recipients Receiving No Pharmacological Prophylaxis. A Propensity Score Matched Cohort Analysis
M. Ivani de Paula,^1,2 S. Bae,¹ J. Garonzik-Wang,¹ C. Felipe,² M. Cristelli,² A. Massie,^1,3 J. Medina-Pestana,² D. Segev,^1,3 H. Tedesco Silva J�nior.²
¹Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Nephrology, Hospital do Rim, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; ³Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD, Brazil.
rATG has become the agent of choice for induction therapy in sensitized patients and those receiving expanded criteria donors (ECD) allografts. However, the optimal dose…
2018 American Transplant Congress
DSA Plus TCMR Leads to Poor Outcomes in Renal Allograft Recipients and This is Markedly Exacerbated by Non-Adherence
D. Chittka, A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.
Starzl Transplant Institute, University of Pittsburgh, Pittsburgh.
Post-transplant DSA is strongly associated with poor renal allograft outcomes but has limited predictive value. In this prospective study we aimed to risk-stratify patients with…
2018 American Transplant Congress
The Ratio of CTLA4 to Perforin and Granzyme B as a Potential Biomarker of Tolerance in Chimeric Renal Transplant Patients
A. Khalil,¹ A. Chhabra,¹ A. Merchak,¹ L. Kahn,¹ J. Leventhal,² S. Ildstad.¹
¹Institute for Cellular Therapeutics, University of Louisville, Louisville, KY; ²Northwestern University, Chicago, IL.
Background: Thirty-six subjects have been enrolled in a phase II clinical trial aimed to induce tolerance through chimerism. Each subject received FCRx (mPBMC enriched in…
2018 American Transplant Congress
Early Utilization of Telehealth in Kidney Transplantation
T. Young, D. Hricik, E. Sanchez, N. Sarabu.
Transplant Institute, University Hospitals of Cleveland, Cleveland, OH.
Introduction: Telehealth is an emerging strategy to improve outcomes and decrease emergency department visits and readmissions. Utility of telehealth in kidney transplantation hasn't been much…
2018 American Transplant Congress
Diagnosis of Acute Renal Rejection Using Saliva Metabolome Analysis
H. Iwamoto,¹ M. Sugimoto,² O. Konnno,¹ Y. Kihara,¹ T. Yokoyama,¹ Y. Nakamura,¹ M. Sunamura,¹ T. Ueno.¹
¹Kidney Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan; ²Health Promotion and Preemptive Medicine, Research and Development Center for Minimally Invasive and Preemptive Medicine, Tokyo Medical University, Hachioji, Japan; ³Department of Digestive Surgery and Transplantation Surgery, Tokyo Medical University, Hachioji, Tokyo, Japan.
(Objective) Wide variety of biomarker discoveries have been conducted to realize low-invasive detection of rejection after renal transplantation. Metabolomics, an omics technology to enable simultaneous…
2018 American Transplant Congress
Kidney Transplant Rejection is Associated with Robust and Prolonged Bioenergetic Reprogramming and Metabolic Maladaptation
A. Zmijewska, J. Zmijewski, J. Chen, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Metabolic plasticity and mitochondrial bioenergetic homeostasis are altered due to a organ ischemia. However, the impact of the alloimmune response on the allograft is…