Articles tagged "Rejection"

2018 American Transplant Congress
High Fibre Diet Induces Donor Specific Kidney Allograft Tolerance in Mice
H. Wu,^1,2 T. Kwan,² Y. Loh,² C. Wang,² L. Macia,² S. Alexander,^2,3 S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³The Children Hospital at Westmead, Sydney, Australia.
Aim: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid sodium acetate (SA) on kidney allograft…
2018 American Transplant Congress
Air Pollution Can Support the Development of Cardiac Allograft Vasculopathy
C. Bara,¹ M. Barten,² D. Boethig,¹ Y. Scheibner,¹ J. Tauber,² H. Reichenspurner,² A. Haverich.¹
¹Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Cardiovascular Surgery, University Heart Center, Hamburg, Germany.
Purpose:Cardiac allograft vasculopathy (CAV) remains one of most important factors leading to graft dysfunction and mortality after heart transplantation (HTx). Thus, the identification of risk…
2018 American Transplant Congress
Analysis of Cost Effectiveness of Treatment for Acute Antibody-Mediated Rejection
C. McDermott, K. Carsky, P. Ferrin, A. Gaines, D. Chernobylsky, M. Killackey, A. Paramesh, R. Zhang, J. Buell.
Tulane University School of Medicine, New Orleans, LA.
Purpose: Because AMR can be a risk factor for graft loss, the expense created by AMR treatment may be subject to scrutiny in patients who…
2018 American Transplant Congress
Failure to Remove De Novo Donor-Specific HLA Antibodies is Influenced by Antibody Properties and Identifies Kidney Recipients with Late Antibody-Mediated Rejection Destined to Graft Loss
A. Nocera,¹ M. Cioni,¹ A. Tagliamacco,² S. Basso,³ A. Innocente,⁴ I. Fontana,⁵ A. Magnasco,¹ A. Trivelli,¹ A. Gurrado,³ M. Ramondetta,⁴ S. Boghen,³ L. Catenacci,³ E. Verrina,¹ G. Garibotto,² G. Ghiggeri,¹ M. Cardillo,⁴ F. Ginevri,¹ P. Comoli.³
¹Pediatric Nephrology Unit, IRCCS G. Gaslini, Genova, Italy; ²Clinical Nephrology Unit, University of Genova, Genova, Italy; ³Transplant Immunology and Pediatric Hematology/Oncology, IRCCS Policlinico S. Matteo, Pavia, Italy; ⁴Transplantation Immunology, Ospedale Maggiore Policlinico, Milano, Italy; ⁵Kidney Transplant Surgery Unit, Ospedale Policlinico San Martino, Genova, Italy.
Late antibody-mediated rejection (AMR) is the major cause of renal allograft loss. Current research is focusing on identifying a performant risk stratification in order to…
2018 American Transplant Congress
Ultrastructural Changes in Lung Allografts: Endothelial Changes Correlate with Donor Specific Antibody & Antibody Mediated Rejection
M. Alexander, A. Bentall, P. Abell Aleff, J. Scott, A. Roden.
Mayo Clinic, Rochester, MN.
Introduction: Antibody mediated rejection (AMR) causes lung allograft (LA) injury. Challenges with C4d interpretation & lack of specific histological criteria account for difficulty in diagnosing…
2018 American Transplant Congress
Performance of Molecular Diagnostic Algorithms of T-Cell Mediated Kidney Rejection (TCMR) in Non-Transplant Biopsies with Interstitial Nephritis
Z. Wang,¹ P. Liu,² G. Tseng,² G. Zeng,¹ P. Randhawa.¹
¹Transplant Pathology, Thomas E Starzl Transplant Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Epidemiology, Graduate School of Public Health, and University of Pittsburgh, Pittsburgh, PA.
DNA microarray based tools for the diagnosis of TCMR have been developed and are now being offered commercially. There is need to further evaluate the…
2018 American Transplant Congress
Treatment of Post Transplant Hepatitis C (HCV) with Direct-Acting Antiviral (DAA) Agents May Improve Liver Function but Does Not Lead to an Increase in Liver Rejection
P. Sheiner, N. Mello, G. Baixauli, M. Einstein, C. Rochon, Y. Kwon, M. Bejon.
Surgery, Hartford Hospital, Hartford, CT.
Previous studies have suggested that with the use of with (DAA) agents to treat post transplant (HCV), there has been an increased incidence of liver…
2018 American Transplant Congress
Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts
A. Gueret-Wardle,¹ G. Lucisano,¹ S. Hassan,¹ P. Brookes,² E. Santos-Nunez,² D. Goodall,¹ C. Clarke,¹ J. Galliford,¹ M. Willicombe,¹ D. Taube.¹
¹Renal and Transplant Centre, Imperial College London NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics, Imperial College London, London, United Kingdom.
Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…
2018 American Transplant Congress
Preformed Donor-Reactive T-Cells That Persist after ABO Desensitization Independently Predict Severe Acute Cellular Rejection after Living Donor Kidney Transplantation
T. Schachtner,^1,2,3 M. Stein,² P. Reinke.^1,2
¹Nephrology and Internal Intensive Care, Charite Campus Virchow Clinic, Berlin, Germany; ²Berlin-Brandenburg Center for Regenerative Therapie (BCRT), Charite Campus Virchow Clinic, Berlin, Germany; ³Berlin Institute of Health (BIH), Charite and Max Delbrueck Center, Berlin, Germany.
Donor-reactive T-cells have been suggested to impact allograft outcome due to a higher incidence of acute celluar rejection. These donor-reactive memory T-cells rapidly acquire effector…
2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…