2018 American Transplant Congress
Impact of De Novo DSA Development and Management on Kidney Transplant Outcomes
Multiple studies have shown that development of donor specific antibodies (DSAs) can have a negative impact on renal allograft outcomes resulting in decreased renal function,…2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…2018 American Transplant Congress
Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection
AT1R-Ab have been associated with kidney allograft rejection; however, their ability to induce a specific rejection phenotype, independent of HLA-DSAs, has not been defined.In a…2018 American Transplant Congress
Marijuana Use Should Not Preclude Consideration for Kidney Transplantation
Hennepin County Medical Center, Minneapolis, MN.
Purpose: Policies for transplant eligibility for tobacco and marijuana (MJ) users vary among transplant centers. The aim of this study was to compare the impact…2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…2018 American Transplant Congress
Clinical Impact of Denovo or Recurrent Donor Specific Antibodies in the First Year Post Kidney Transplant in Patients on Early Steroid Withdrawal Immunosupression Regimen
Division of Renal Disease and Hypertension, Indiana University Health, Indianapolis, IN.
Background: Immunologic risk monitoring of recipients of kidney transplant(Tx) using donor specific antibodies (DSA) has become a standard practice in most Tx centers in the…2018 American Transplant Congress
The Results of the PRISM (Prediction of Rejection In Sensitized Patient Blood SaMples) Trial with a Novel Bioassay
Surgery and Medicine, University of California San Francisco, San Francisco.
Background. kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of BPAR and immune quiescence in kidney tx. This is the first…2018 American Transplant Congress
An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss
Background:Banff Classification accepts two histomorphological features as surrogates of HLA Antibody-Antigen interaction on renal endothelium: C4d staining and microvascular inflammation scores (MVI sum score:ptc+g≥2) which…2018 American Transplant Congress
Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation
Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate…2018 American Transplant Congress
Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin…
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