2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in a Non-Human Primate Identifies Inflammation as a Risk Factor in Chronic Antibody Mediated Rejection
IntroductionChronic alloantibody mediated rejection (CAMR) is a major risk factor in renal allografts. Some inflammation is commonly identified within CAMR, though mostly low grade, and…2018 American Transplant Congress
Clinical Impact of Denovo or Recurrent Donor Specific Antibodies in the First Year Post Kidney Transplant in Patients on Early Steroid Withdrawal Immunosupression Regimen
Division of Renal Disease and Hypertension, Indiana University Health, Indianapolis, IN.
Background: Immunologic risk monitoring of recipients of kidney transplant(Tx) using donor specific antibodies (DSA) has become a standard practice in most Tx centers in the…2018 American Transplant Congress
The Results of the PRISM (Prediction of Rejection In Sensitized Patient Blood SaMples) Trial with a Novel Bioassay
Surgery and Medicine, University of California San Francisco, San Francisco.
Background. kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of BPAR and immune quiescence in kidney tx. This is the first…2018 American Transplant Congress
An Integrative Approach for the Assessment of Peritubular Capillaritis Extent and Score in Microvascular Inflammation – Association with Transplant Glomerulopathy and Graft Loss
Background:Banff Classification accepts two histomorphological features as surrogates of HLA Antibody-Antigen interaction on renal endothelium: C4d staining and microvascular inflammation scores (MVI sum score:ptc+g≥2) which…2018 American Transplant Congress
Comparison of Microvascular Inflammation in Renal Allograft Tissue between ABO Incompatible and ABO Compatible Kidney Transplantation
Background: Microvascular inflammation (MVI) is considered as a pathological marker for antibody-mediated rejection (AMR) in the presence of donor-specific antibody (DSA). We aimed to investigate…2018 American Transplant Congress
Impact of Vitamin D Status on Immune-Mediated Graft Function Following Kidney Transplantation
Ubiquitous expression of vitamin D receptors on antigen-presenting cells has sparked interest into its immunomodulatory effects. While previous literature has described the effect of vitamin…2018 American Transplant Congress
Melatonin Prolongs Heart Allograft Survival by Induction of Foxp3+ Regulatory T Cells
The First Affiliated Hospital of Sun Yet-sen University, Guangzhou, China.
Objective: This study was aimed to investigate the effect of melatonin on heart allograft survival and explore the underlying mechanism. Methods and Results: Balb/c and…2018 American Transplant Congress
Automated Systems to Identify and Address Adherence Barriers Result in Sustained Reduction of Late Allograft Rejection
Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Background: Patient-identified barriers to taking immunosuppressive medications are associated with rejection and allograft loss, yet interventions targeting adherence barriers are rarely integrated into clinical practice.…2018 American Transplant Congress
Two Similar Risk Models Identify Different Patients for Graft Loss: Implications for Clinical Trials in DSA+ Kidney Transplant Recipients
William J von Liebig Transplant Center, Mayo Clinic, Rochester.
Introduction. Kidney Transplant Recipients (KTx) with donor-specific alloantibody (DSA) at transplantation have increased death-censored graft failure (DCGF) due to chronic antibody mediated rejection (cABMR), but…2018 American Transplant Congress
A “Multi-Omic” Analysis of Proteome and Metabolome for Acute Rejection and PVAN in Kidney Transplantation
Background: Most effort in identifying biomarkers have used gene expression analyses. Proteomics and metabolomics are useful to identify surrogate biomarkers in monitoring transplanted kidney and…
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