2018 American Transplant Congress
Magnitude of Pre-Biopsy Decline in Renal Function and Its Association with Allograft Rejection
Introduction: Acute rejection is a significant cause of morbidity, and transplant biopsy remains the gold standard for diagnosing rejection. To our knowledge there have been…2018 American Transplant Congress
Metabolic Regulation of Neuropeptides Induces Weight Loss and is Linked to Prolongation of Allograft Survival
Obesity has become a common comorbidity among transplant recipients that is linked to inferior transplant outcome through far-reaching effects on metabolism, inflammation and immunity. Increasingly,…2018 American Transplant Congress
Optimal Anti-Thymocyte Globulin Dose for Induction Immunosuppression in Kidney Transplantation
Organ Transplant Program, Swedish Medical Center, Seattle, WA.
Anti-thymocyte globulin (ATG) is used as induction immunosuppression in kidney transplantation to prevent allograft rejection. ATG causes dose-dependent lymphocyte depletion, yet optimal dose is unknown.…2018 American Transplant Congress
Triptolide Reduces the Required Dose of Tacrolimus by Attenuating Inflammation, Enhancing Immunosuppression, and Increasing Donor Chimerism in a Heterotopic Hindlimb Transplantation Model
Plastic and Reconstructive Surgery, Shanghai Ninth Hospital, Shanghai, China.
Background: Induction of tolerance and minimizing the toxicity of immuno- suppression are two fundamental goals in vascularized composite allotrans- plantation. Accumulating data indicate that triptolide…2018 American Transplant Congress
Preemptive Plasma Therapy and Eculizumab (ECU) Rescue for Atypical Hemolytic Uremic Syndrome (aHUS) Relapse Following Kidney Transplantation (KTX)
Introduction: KTX in aHUS patients is associated with a high rate of relapse and graft loss. Here, we report on seven aHUS cases with end-stage…2018 American Transplant Congress
Accommodation and Antibody Mediated Rejection Are Associated with Distinct TACI Polymorphisms in Kidney Transplant Recipients
1Surgery, University of Michigan, Ann Arbor, MI; 2Pathology, University of Michigan, Ann Arbor, MI.
A. Trans-membrane Activator and CAML Interactor (TACI) gene is among the 5% most polymorphic genes in humans, TACI controls B cell differentiation and memory and…2018 American Transplant Congress
Determining the Utility of Protocol Biopsies in Kidney Transplant Recipients
1Virginia Commonwealth University, Falls Church; 2Inova Fairfax Hospital, Falls Church.
Protocol biopsies may allow for early detection and treatment of kidney transplant rejection or other correctable pathology, leading to improved graft survival. Unfortunately, biopsies may…2018 American Transplant Congress
Kidney Transplant Rejection is Associated with Robust and Prolonged Bioenergetic Reprogramming and Metabolic Maladaptation
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Metabolic plasticity and mitochondrial bioenergetic homeostasis are altered due to a organ ischemia. However, the impact of the alloimmune response on the allograft is…2018 American Transplant Congress
Inflammation in Fibrotic Areas (i-IF/TA) Identifies a T Cell-Mediated Rejection Component of IF/TA with Poor Kidney Allograft Outcome
Paris Translational Research Center for Organ Transplantation, Paris, France.
Addressing the etiological heterogeneity of interstitial fibrosis in kidney allografts represents an important challenge to improve long-term transplant outcomes. We investigated the determinants, clinical and…2018 American Transplant Congress
Respiratory Viral Infections Induces Exosomes and Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, Following Human Lung Transplantation
Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and…
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