2018 American Transplant Congress
Early Experience Using Donor-Derived Cell-Free DNA for Detection of Rejection in Kidney Transplantation
Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.
Introduction:Donor-derived cell free DNA (ddDNA; Allosure, CareDX) has been validated as a non-invasive test that can discriminate rejection from non-rejection in kidney transplantation, but has…2018 American Transplant Congress
Impact of Postoperative Serum Chloride Changes on Graft Function and Acute Rejection in Recipients of Living Kidney Transplants
Background: In the non-transplant setting, hyperchloremia has been associated with kidney injury. We sought to study the impact of serum chloride (SCl) on transplant outcomes.Methods:…2018 American Transplant Congress
Regulation of Indoleamine 2,3-Dioxygenase in Porcine Kidney Transplants
1Augusta University, Augusta, GA; 2Gift of Life Michigan, Ann Arbor, MI; 3Norwood VAMC, Augusta, GA.
Indoleamine 2,3-dioxygenase (IDO) is an endogenous immunosuppressant exerting its effects through tryptophan depletion and kynurenine generation. Kynurenine 3-monooxygenase (KMO) is a downstream enzyme from IDO…2018 American Transplant Congress
Cytokine Profiles in Children after Pediatric Kidney Transplantation with Acute and Chronic Rejection
Pediatric Nephrology, Hannover Medical School, Hannover, NDS, Germany.
BackgroundActually, a diagnosis of acute cellular or chronic humoral rejection after pediatric kidney transplantation (pKTX) can only be secured by graft biopsy. Until now, no…2018 American Transplant Congress
Intravenous Immunoglobulins and Methylprednisolone Stabilizes Renal Allograft Function in the Majority of Patients with C-aABMR
Erasmus Medical Center, Rotterdam, Netherlands.
BackgroundChronic active antibody mediated rejection (c-aABMR) leads to progressive decline in allograft function and is a major contributor to long-term kidney allograft loss. To date,…2018 American Transplant Congress
The Impact of Lymphocele Formation after Kidney Transplantation on De Novo Donor Specific Antibody Formation
Introduction: Lymphocele formation is a common complication after kidney transplantation and has been linked to rejection episodes. However, long-term outcome data are scarce and the…2018 American Transplant Congress
Impact of De Novo DSA Development and Management on Kidney Transplant Outcomes
Multiple studies have shown that development of donor specific antibodies (DSAs) can have a negative impact on renal allograft outcomes resulting in decreased renal function,…2018 American Transplant Congress
Noninvasive Quantization of Intra-Renal Allograft C4d Deposition with Targeted Ultrasound Imaging
Antibody-mediated rejection (AMR) has emerged as the major cause of renal allograft dysfunction. C4d, a specific marker of AMR diagnosis, was strongly recommended for routine…2018 American Transplant Congress
Anti-Angiotensin II Type 1-Receptor Antibodies (AT1R-Ab) Induce a Specific Phenotype of Rejection Distinct from HLA Antibody-Mediated Rejection
AT1R-Ab have been associated with kidney allograft rejection; however, their ability to induce a specific rejection phenotype, independent of HLA-DSAs, has not been defined.In a…2018 American Transplant Congress
Marijuana Use Should Not Preclude Consideration for Kidney Transplantation
Hennepin County Medical Center, Minneapolis, MN.
Purpose: Policies for transplant eligibility for tobacco and marijuana (MJ) users vary among transplant centers. The aim of this study was to compare the impact…
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