2019 American Transplant Congress
Circulating Donor Specific Antibody and Biopsy C4d Positivity in Pancreas Rejection Increase the Probability of Earlier Return to Insulin after Rejection
*Purpose: Outcome data following rejection in pancreas recipients are sparse. We sought to study the influence of C4d positivity and the presence of circulating DSA…2019 American Transplant Congress
A Metagene Signature of Lymphocytic Bronchitis Following Lung Transplantation
*Purpose: Lymphocytic bronchitis (LB) precedes chronic lung allograft dysfunction (CLAD). Peri-vascular (A-grade) and peri-bronchiolar (B-grade) lymphocytic inflammation are traditional markers of acute cellular rejection. The…2019 American Transplant Congress
Tissue Resident Memory T Cells in Murine Renal Transplantation
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…2019 American Transplant Congress
Single Cell Analysis of Kidney Allograft Rejection
*Purpose: Rejection therapies (corticosteroids and antilymphocyte globulins) have not changed in over 50 years. In part this is due to a knowledge deficit of signaling…2019 American Transplant Congress
CD19+Tim-1+ Regulatory B Cells Mediate the Balance of Th17 Treg to Decrease the Level of Donor-Specific Antibodies in Mice Secondary Skin Transplantation Model
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: In this study, we were aimed to explore the potential influence of CD19+Tim-1+ Regulatory B cells (Bregs) on the production of DSAs in a…2019 American Transplant Congress
Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients
1Icahn School of Medicine at Mount Sinai, New York, NY, 2The University of Sydney, Sydney, Australia
*Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…2019 American Transplant Congress
Use of mTOR Inhibitors in Hypersensitized Kidney Transplant Recipients: Breaking False Myths
*Purpose: Many centers avoid the use of mTOR inhibitors (mTORi) in hypersensitized kidney transplant recipients and usually employ an immunosuppression based on Mycophenolic Acid (MPA),…2019 American Transplant Congress
The Negative Costimulatory Pd-1/pd-l1 Pathway Is Upregulated In Early Cell-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Extensive transcript analysis has been performed on grafts at the time of rejection, but gene expression preceding overt rejection is less well studied.*Methods: We…2019 American Transplant Congress
5-Year Post-Transplant Outcomes with Bortezomib-Based Desensitization in Renal Transplant Recipients
1U of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH
*Purpose: Renal transplant (RT) after desensitization (DS) has been associated with increased rejection rates. Proteasome inhibitor(PI)-based DS yields significant reductions in HLA Ab among sensitized…2019 American Transplant Congress
Impact of Transplant Ureteral Stricture Location and Type of Ureteral Revision on Long-Term Graft Survival and Patient Outcomes in Kidney Transplantation
*Purpose: Transplant ureteral strictures are a major cause of morbidity following kidney transplantation and often require surgical revision including ureteroureterostomy (UU) and neocystoureterostomy (NC). Our…
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