Articles tagged "Rejection"

2019 American Transplant Congress
Acquired Resistance to Transplantation Tolerance as a Result of Prior Pregnancy Requires B Cells
D. V. Tran, A. N. Suah, S. Khiew, J. S. Young, Q. Wang, D. Yin, M. Alegre, A. S. Chong
Departments of Surgery and Medicine, University of Chicago, Chicago, IL
*Purpose: Clinical data suggest allogeneic pregnancy is a sensitizing event; however, data from mouse models suggests it induces fetal-specific regulatory T cell (Treg) expansion and…
2019 American Transplant Congress
Ligation Of Hla Class Il Molecules Disrupts Endothelial Barrier Through Src-dependent Ve-cadherin Destabilization
F. Li¹, R. A. Sosa¹, N. M. Valenzuela¹, E. Rozengurt², E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Digestive Diseases Research Center, University of California, Los Angeles, Los Angeles, CA
*Purpose: Microvascular inflammation, vascular permeability, and accumulation of intravascular mononuclear cells are characteristics of acute and chronic antibody-mediated rejection. Vascular endothelial cadherin (VE-Cadherin) is a…
2019 American Transplant Congress
A Comprehensive and Updated Analysis of Combined Heart-Kidney Transplants Utilizing the United Network for Organ Sharing Database
V. M. Lim¹, N. Khurmi¹, W. R. Hewitt, Jr.², A. K. Mathur², O. E. Pajaro³, D. E. Jaroszewski³, B. D. Gaitan¹
¹Anesthesiology, Mayo Clinic Arizona, Phoenix, AZ, ²Transplantation Surgery, Mayo Clinic Arizona, Phoenix, AZ, ³Cardiovascular and Thoracic Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Analysis of combined heart-kidney transplants (HKTx) reveals equivalent or improved patient survival and reduced allograft rejection rates as compared to single-organ transplants. The rate…
2019 American Transplant Congress
Bronchoalveolar Lavage Biomarkers Predict Lung Transplant Survival
A. Zarinsefat¹, J. Y. Yang², R. Sarwal¹, J. Liberto¹, D. Watson³, S. Verleden⁴, M. Sarwal¹
¹UC San Francisco, San Francisco, CA, ²Johns Hopkin, Baltimore, MD, ³Kit Bio, Los Altos, CA, ⁴KU Leuven, Leuven, Belgium
*Purpose: In lung transplants (LTx), chronic rejection remains a major cause of morbidity and mortality following transplantation, mainly from chronic lung allograft dysfunction (CLAD). Two…
2019 American Transplant Congress
A National Survey of Immunosuppression Strategies in Intestinal Transplantation
M. Segovia¹, T. Beduschi², J. Boike³, D. Farmer⁴, S. Horslen⁵, K. Iyer⁶, S. Jafri⁷, A. Langnas⁸, C. Matsumoto⁹, A. Mavis¹, G. Mazariegos¹⁰, S. Nagai⁷, J. O'Leary¹¹, Y. Patel¹, D. Sudan¹, N. Sulejmani⁷, B. Summers⁷, T. Schiano⁶
¹Duke, Durham, NC, ²Univ Miami, Miami, FL, ³NWU, Chicago, IL, ⁴UCLA, Los Angeles, CA, ⁵Seattle Child, Seattle, WA, ⁶Mt Sinai, NY, NY, ⁷Henry Ford, Detroit, MI, ⁸UNMC, Omaha, NE, ⁹Georgetown, Washington, DC, ¹⁰UPMC, Pittsburgh, PA, ¹¹Dallas VAMC, Dallas, TX
*Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
2019 American Transplant Congress
Single Cell RNA-seq Analysis of Antibody-Mediated Rejection Reveals Endothelial – Pericyte NOTCH Signaling
A. F. Malone, A. Chadha, H. Wu, S. Ramakrishnan, E. Donnelly, B. D. Humphreys
Washington University School of Medicine, Saint Louis, MO
*Purpose: To precisely define endothelial cell responses in AMR we performed comprehensive single cell RNA-seq on a human kidney biopsy with AMR.*Methods: Single cell libraries…
2019 American Transplant Congress
Clinical Response to Pathological Finding in Uterus Transplantation
L. Johannesson, G. Testa
Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
*Purpose: Uterus transplantation has recently proven to be the first successful treatment for absolute uterine factor infertility with demonstration of live births. All reported episodes…
2019 American Transplant Congress
Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics
J. Tchervenkov¹, M. Nguyen², S. Negi¹, S. Paraskevas¹
¹RIMUHC, Montreal, QC, Canada, ²SSM Health Saint Louis University Hospital, St. Louis, MO
*Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…
2019 American Transplant Congress
Clinical Impact of Race and Timing of Acute Rejection on Recipients of Kidney Transplant on Early Steroid Withdrawal Protocol
O. Adebiyi, S. Yaqub, W. Goggins, D. Mishler, T. Taber, A. Sharfuddin
Indiana University, Indianapolis, IN
*Purpose: There has been conflicting reports on the impacts of the timing of acute rejection (AR) (early vs late) on the overall outcome of a…
2019 American Transplant Congress
Pre-Transplant Multidimensional Flow Cytometric Analysis of Kidney Transplant Recipients Reveals Novel Immune Signature of Allograft Rejection
P. Schroder¹, J. S. Yi¹, K. J. Weinhold¹, C. Chan², M. Joshi³, C. Walters³, J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, ³Substrate Services Core and Research Support, Duke University Medical Center, Durham, NC
*Purpose: Multicolor flow cytometry and multiplex assay platforms have revolutionized immune cell phenotyping and functional analyses, but these powerful tools have not demonstrated clinically meaningful…