Articles tagged "Rejection"

2019 American Transplant Congress
Detection and Desensitization of Donor-Specific Antibody Reduces Risk of Early but Not Late Renal Transplant Failure in a Cohort of 1000 Cases
M. Tsai, C. Lee, C. Yang, C. Chen
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
*Purpose: The Human Organ Transplant Act in Taiwan was promulgated in 1987 and, thereafter, organ transplantation from brain-dead donors legalized. To review the results of…
2019 American Transplant Congress
The Molecular Pathology of Immune Checkpoint Inhibitor-Associated Renal Allograft Rejection: Overlap with Acute Interstitial Nephritis
B. Adam¹, C. Boils², L. Bu³, K. Renaudin⁴, K. Wen¹, M. Mengel¹
¹University of Alberta, Edmonton, AB, Canada, ²Arkana Labs, Little Rock, AR, ³University of Minnesota, Minneapolis, MN, ⁴CHU Nantes, Nantes, France
*Purpose: The use of immune checkpoint inhibitors (ICIs) for various malignancies has been associated with numerous immunological adverse events, including acute interstitial nephritis (AIN) in…
2019 American Transplant Congress
The Impact of Early Subtherapeutic Tacrolimus Troughs with Alemtuzumab Induction
L. Bowman¹, E. Yanqui¹, C. Truong¹, R. Baliga², A. Brueckner¹
¹Tampa General Hospital, Tampa, FL, ²Florida Kidney Physicians, Tampa, FL
*Purpose: Prior studies in kidney transplant recipients (KTR) have demonstrated that lower tacrolimus (TAC) exposure during the first week is associated with an increased incidence…
2019 American Transplant Congress
Use of an Ideal Body Weight-Based Rabbit Anti-Thymocyte Globulin Dosing Protocol in Kidney Transplant Recipients to Decrease Cost and Maintain Outcomes at a Large Academic Medical Center
L. J. Myhre¹, R. J. Bubik¹, K. T. Peterson¹, H. A. Personett¹, S. A. Crow¹, P. G. Dean²
¹Pharmacy, Mayo Clinic, Rochester, MN, ²Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: This quality improvement study sought to assess if rejection post-transplant was increased following implementation of an ideal body weight (IBW)-based dosing protocol for patients…
2019 American Transplant Congress
Use of Eculizumab for Active Antibody-Mediated Rejection That Occurs Early Post-Kidney Transplantation: A Consecutive Series of 15 Cases
E. Tan¹, B. J. Andrew², P. G. Dean², M. F. Shaheen¹, M. D. Stegall², C. A. Schinstock²
¹Division of Transplantation Surgery, Mayo Clinic Rochester, Rochester, MN, ²The William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic Rochester, Rochester, MN
*Purpose: Active antibody-mediated rejection (ABMR) that occurs during the amnestic response within the first month post-transplant is a rare but devastating cause of early allograft…
2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
P. K. Gupta¹, M. L. Miller², L. Chen¹, Y. Wang¹, J. Conejo-Garcia³, A. Chong¹, M. Alegre¹
¹University of Chicago, Chicago, IL, ²University of Pittsburgh, Pittsburgh, PA, ³Moffitt Cancer Center & Research Institute, Tampa, FL
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…
2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
E. T. Chambers¹, O. Martinez², M. Robien³, C. Chan¹, R. Ettenger⁴, P. Grimm⁵, H. Lee¹, E. Reed⁴, L. Stempora⁶, M. Sarwal⁷, B. Warshaw⁸, C. Zhao¹, A. D. Kirk⁶
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Stanford, Palo Alto, CA, ³NIH, Bethesda, MD, ⁴Pediatrics, UCLA, Los Angeles, CA, ⁵Pediatrics, Stanford, Stanford, CA, ⁶Surgery, Duke University, Durham, NC, ⁷Pediatrics, UCSF, San Francisco, CA, ⁸Pediatrics, Emory University, Atlanta, GA
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…
2019 American Transplant Congress
Newly-Revealed Antibody Targets Lead to the Early Loss of Triple Knockout Pig Kidneys in a Pig to Baboon Model
Y. Ariyoshi¹, K. Takeuchi¹, T. Pomposelli¹, D. K. Ekanayake-Alper¹, C. Schuetz¹, H. Sahara¹, L. Boyd¹, E. Estime¹, S. Arn¹, D. Ayares², M. Lorber³, M. Sykes¹, D. Sachs¹, K. Yamada¹
¹CCTI/Surgery, Columbia University Medical Center, New York, NY, ²Revivicor Inc., Blacksburg, VA, ³Lung BioTechnology PBC, Silver Spring, MD
*Purpose: We have achieved >6 months survival of a life-supporting kidney with a vascularized thymus (VT) in a pig-to-baboon model. While improved survival has been…
2019 American Transplant Congress
Transplanting Thoracic Organs From Hcv Donors To Uninfected Patients: Evaluation Of Lung Allografts
Y. Lo¹, R. F. Padera¹, H. R. Mallidi², H. J. Goldberg³, S. K. Singh², A. Coppolino, III⁴, L. R. Baden⁵, A. E. Woolley⁵
¹Pathology, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁵Infectious Diseases, Brigham and Womens Hospital, Boston, MA
*Purpose: Prior to the development of direct acting antiviral (DAA) therapy for hepatitis C virus (HCV), there was concern that patients who received lungs from…
2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…