Articles tagged "Rejection"

2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
H. Deng, R. Wang, J. Shen, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…
2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
E. Van Loon¹, S. Gazut², S. Yazdani¹, E. Lerut¹, H. de Loor¹, M. Coemans¹, L. Noël³, L. Thorrez¹, L. Van Lommel¹, F. Schuit¹, D. Lambrechts¹, T. Van Brussel¹, B. Sprangers¹, D. Kuypers¹, M. Essig⁴, W. Gwinner⁵, D. Anglicheau⁶, P. Marquet⁷, M. Naesens¹
¹Catholic University Leuven, Leuven, Belgium, ²CEA, Gif-sur-Yvette, France, ³Necker-Enfants Malades Institute, Paris, France, ⁴CHU Limoges, Limoges, France, ⁵Hannover Medical School, Hannover, Germany, ⁶Paris Descartes, Sorbonne Paris Cité University, Paris, France, ⁷RTRS Centaure, Necker Hospital, Paris, France
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
2019 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligands 1 and 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. Matar, Y. Dong, B. Lovasik, D. Mathews, A. Ghosh, C. Breeden, A. Stephenson, W. Kitchens, A. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2019 American Transplant Congress
High Fibre Diet Prevents Transplant-Associated Dysbiosis and Prevents Kidney Allograft Rejection
J. J. Singer¹, H. Wu¹, T. Kwan¹, Y. Loh¹, C. Wang¹, J. Tan², L. Macia², S. Alexander³, S. Chadban¹
¹Kidney Node Laboratory, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ²Nutritional Immunometabolism Lab, Charles Perkins Centre, The University of Sydney, Sydney, Australia, ³The Children's Hospital Westmead, Sydney, Australia
*Purpose: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid (SCFA) sodium acetate (SA) on kidney…
2019 American Transplant Congress
Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation
T. Ueno¹, T. Kodama¹, Y. Noguchi¹, M. Nomura¹, R. Saka¹, Y. Takama¹, Y. Tazuke¹, K. Bessho², H. Okuyama¹
¹Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
*Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…
2019 American Transplant Congress
Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters
C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Stanford University, Palo Alto, CA
*Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…
2019 American Transplant Congress
Comparison with Solid Organ Transplants Reveals Distinct Face Transplant Rejection Gene Signature That Reflects the Unique Immunobiology of Skin
T. Win, B. Dyring-Andersen, R. Lopdrup, J. Teague, N. Murakami, A. Chandraker, S. G. Tullius, B. Pomahac, L. V. Riella, R. A. Clark
Brigham and Women's Hospital, Boston, MA
*Purpose: Skin containing transplants, such as face transplants, are immunologically unique. We compared the gene expression profiles of acute cellular rejection in human face transplants…
2019 American Transplant Congress
Urinary Biomarkers- CXCL9 and CXCL10 for Non-Invasive, Early Diagnosis of Rejection in Pediatric Renal Transplantation
R. P. George¹, B. Hanberry², I. Dave², B. Lee², R. Garro¹, C. McCracken², B. Warshaw¹
¹Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, ²Pediatrics, Emory University, Atlanta, GA
*Purpose: Renal transplantation is the treatment of choice for End Stage Renal Disease, but requires strict medication adherence and lifelong surveillance for rejection, infection and…
2019 American Transplant Congress
The Effect Of Tacrolimus Trough Variability On Kidney Transplant Outcomes
S. Heeney¹, K. R. Szempruch¹, R. Lee¹, A. Mintz², P. Serrano¹, R. Detwiler¹, C. Doligalski¹
¹University of North Carolina Medical Center, Chapel Hill, NC, ²University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC
*Purpose: High variability in tacrolimus as assessed by tacrolimus coefficient of variability (TCV) in trough levels of kidney transplant recipients (KTRs) has been associated with…
2019 American Transplant Congress
Torque Teno Virus is a Prognostic Biomarker for Acute Biopsy-Proven Alloreactivity in Kidney Transplants
K. Doberer
Dpt. of Internal Medicine III, Div. of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
*Purpose: Drug-induced immunosuppression in kidney transplantation is crucial to prevent allograft rejection, but increases risk for infectious, cardiovascular and malignant disease. Tailoring of immunosuppressive drug…