Articles tagged "Rejection"

2019 American Transplant Congress
Solving Target Recognition and Activation Mediated by Non-HLA Agonistic Antibodies Targeting ETAR
A. Philippe¹, R. Catar¹, P. Scheerer², M. Szczepek², D. Dragun¹
¹Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany, ²Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin, Berlin, Germany
*Purpose: Endothelin-1 type A receptor (ETAR) exhibits multiligand binding abilities and may signal upon natural ligand Endothelin-1 (ET-1) and non-HLA ETAR-agonistic IgG (ETAR-IgG)-mediated stimulation similar…
2019 American Transplant Congress
Increase in 48 Month Cumulative Acute Rejection Rates in the Most Recent Cohort: The 2018 Transplant Report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS)
V. Dharnidharka¹, C. Cramer², A. Chua³, A. Moudgil⁴, K. Martz⁵, T. Blydt-Hansen⁶, J. Smith⁷, A. Neu, on Behalf of The NAPRTCS Investigators⁸
¹Washington University in St. Louis, Saint Louis, MO, ²Mayo Clinic, Rochester, MN, ³Duke University, Durham, NC, ⁴Children's National Medical Center, Washington, DC, ⁵Emmes Corporation, Rockville, MD, ⁶BC Children's Hospital, Vancouver, BC, ⁷Seattle Children's Hospital, Seattle, WA, ⁸Johns Hopkins University, Baltimore, MD
*Purpose: The NAPRTCS registry has collected data on children receiving kidney transplants in North America since 1987. The registry has served to document and influence…
2019 American Transplant Congress
A Potential Role for IgE-Mediated Immune Response in the Pathogenesis of Chronic Antibody-Mediated Rejection
F. Rascio¹, P. Pontrelli², G. S. Netti³, E. Manno¹, B. Infante¹, S. Simone², G. Castellano², M. Seveso⁴, E. Cozzi⁴, L. Gesualdo², G. Stallone¹, G. Grandaliano¹
¹Department of Medical and Surgical Sciences, Nephrology Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy, ²Department of Emergency, and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy, ³Dept. of Medical and Surgical Sciences, Clinical Pathology Unit, University of Foggia, Foggia, Italy, ⁴Department of Cardiac, Thoracic and Vascular Sciences, Transplant Immunology Unit, University of Padua, Padova, Italy
*Purpose: Chronic antibody-mediated rejection (CAMR) is the main cause of graft loss and shares with systemic lupus erythematosus (SLE) the antibody-mediated kidney damage and the…
2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
Rapid Detection of Kidney Transplant Injury by Quantifying Donor-Derived Cell-Free Deoxyribonucleic Acid via Massively Multiplex Polymerase Chain Reaction
T. K. Sigdel¹, F. Acosta², S. Navarro², B. Zimmermann², Z. P. Demko², S. Moshkevich², P. R. Billings², M. M. Sarwal¹
¹University of California San Francisco, San Francisco, CA, ²Natera Inc., San Carlos, CA
*Purpose: Plasma donor-derived cell-free DNA (dd-cfDNA) is a proven marker for allograft rejection in patients with kidney transplant (KT). Our goal was to assess performance…
2019 American Transplant Congress
Back Signaling of HLA Class I Molecules and NK Cell Receptor Ligands in Renal Epithelial Cells Contributes to the Rejection-Specific Microenvironment
E. Chichelnitskiy¹, J. Egelkamp¹, K. Daemen¹, J. Keil¹, C. Neudörfl¹, J. Bräsen², J. Schmitz², H. Haller³, C. Blume⁴, C. Falk⁵
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Nephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Institute of Technical Chemistry, Leibniz University, Hannover, Germany, ⁵Institute of Transplant Immunology, Hannover Medical School; DZIF, German Center for Infection Research, TTU-IICH, Hannover/Braunschweig, Germany
*Purpose: During the last years, diverse harming mechanisms of donor-specific antibodies (DSA) to endothelial cells have been studied accompanied by an emerging evidence of NK…
2019 American Transplant Congress
Outbreak of Pneumocystis Pneumonia in a Transplant Center Linked to a Single Genotype of Pneumocystis jirovecii: Effects of Cytomegalovirus Infection and Allograft Rejection
S. Hosseini-Moghaddam¹, S. Dufresne², M. Shokoohi³, G. Singh¹, E. HunterGutierrez¹, P. Dufresne², A. House¹, P. Luke¹, A. Nagpal¹, P. Marotta¹, A. Humar⁴, A. Jevnikar¹, D. Kumar⁴
¹Western University,LHSC,University Hospital, London, ON, Canada, ²Maisonneuve-Rosemont Hospital,Université de Montréal, Montreal, QC, Canada, ³Epidemiology and Biostatistics, Western University, London, ON, Canada, ⁴University of Toronto, University Health Network, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Although post-transplant pneumocystis pneumonia (PCP) outbreaks have been reported from Asia, Australia and Europe, there are limited data from North America. We investigated transmissibility…
2019 American Transplant Congress
Liver Allograft Provides Protection Against Cardiac Allograft Rejection In Combined Heart And Liver Transplantation
K. Zhao¹, R. Wang², M. Kamoun³, K. Olthoff¹, M. Hoteit⁴, E. Rame⁵, M. Levine¹, R. Mclean⁵, P. Abt¹
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Jefferson University, Philadelphia, PA, ³Pathology, University of Pennsylvania, Philadelphia, PA, ⁴Gastroenterology, University of Pennsylvania, Philadelphia, PA, ⁵Cardiology, University of Pennsylvania, Philadelphia, PA
*Purpose: Combined heart-liver transplant (CHLT) is indicated for patients with combination of heart and liver disease or amyloid heart disease for whom liver transplant can…
2019 American Transplant Congress
Anti-Complement Component 5 Antibody Based Immunosuppression Induced Accommodation in ABO Incompatible Heart Transplantation
S. Park¹, S. Lee¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn³, J. Yang⁴
¹Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Plasmapheresis in combination with immunoglobulin and rituximab is often used to induce accommodation in ABO-incompatible (ABOi) living-donor transplantation; however, this regimen cannot be applied…