Articles tagged "Rejection"

2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
CD56+CD57+ Infiltrate is a Predominant Subset of Infiltrating Natural Killer Cell in Renal Transplant Biopsies with Antibody-Mediated Rejection
H. Jung¹, Y. Wee², J. Kim², M. Choi², J. Choi², H. Kwon², J. Jung², S. Kim³, Y. Cho⁴, Y. Park⁴, H. Go⁴, M. Han⁵, Y. Kim², D. Han², S. Shin²
¹Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Department of Convergence Medicine, Asan Institute for life sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁵Department of Clinical Epidemiology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: To verify a subset of intragraft and circulating natural killer cells associated with kidney allograft rejection and fibrosis.*Methods: Thirty-nine clinically indicated transplant biopsies performed…
2019 American Transplant Congress
Is Bariatric Surgery Feasible in the Setting of Liver and Kidney Transplants?
L. M. Potter, A. Saharia, C. Mobley, K. Lunsford, M. Hobeika, N. Tariq, H. Podder, A. O. Gaber, R. M. Ghobrial
Liver Transplant and Hepatobiliary Surgery, The Houston Methodist Hospital, Houston, TX
*Purpose: Bariatric surgery benefits obese patients by promoting weight loss, improving quality of life, and reducing morbidity and mortality rates. There is concern, however, that…
2019 American Transplant Congress
Reference Ranges Donor-Derived Cell-Free DNA in a Heart Transplant Population
A. Kao¹, S. Dholakia², M. Deng³
¹Saint Luke's, Kansas City, MO, ²CareDx, Brisbane, CA, ³University of Los Angeles, Los Angeles, CA
*Purpose: Elevations in donor-derived cell-free DNA (dd-cfDNA) ≥0.20 % in heart transplant recipients (HTR) has been shown to be associated with a probability of acute…
2019 American Transplant Congress
Using a Massive Open Online Course on Clinical Kidney, Prancreas and Islet Transplantion in Different Settings of Transplant Education
P. G. De Jong¹, R. A. Hendriks¹, F. Luk², M. E. Reinders²
¹Center for Innovation in Medical Education, Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
*Purpose: In 2016 our center launched a Massive Open Online Course (MOOC) on Kidney, Pancreas and Islet Transplantation. As opposed to on-campus education, this course…
2019 American Transplant Congress
Outcomes of Phenotypes in Early Subclinical Inflammation (SCI) Determined by Presence of Interstitial Inflammation with or without Concomitant Tubulitis
R. Mehta, S. Tandukar, D. Jorgensen, I. Owoyemi, P. Sood, A. Tevar, S. Hariharan
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Low levels of renal allograft inflammation in the early post transplant period appear to have an impact on renal architecture and function. However, the…
2019 American Transplant Congress
Low Specific Gravity Of First Morning Urine Predicts Bkvn in Kidney Transplant Recipients With Bk Viruria
G. Huang¹, X. Chen¹, Z. Wang², Y. Nuertai², W. Chen³, S. Yang³, P. Chen⁴, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Clinical Medicine, Sun Yat-sen University Zhongshan School of Medicine, Guangzhou, China, ³Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. BKV usually infects urinary tract retrogradely. The collecting duct…
2019 American Transplant Congress
Infectious Complications after Treatment of Antibody-Mediated Kidney Allograft Rejection: A National Cohort Study
N. Perrottet¹, D. Golshayan², O. Manuel², V. Aubert², M. Koller³, K. Hadaya⁴, L. Bühler⁴, T. Mueller⁵, U. Huynh-Do⁶, S. Dahdal⁶, I. Binet⁷, M. Dickenmann³, S. Schaub³, J. Steiger³, M. Pascual², M. Fernández-Ruiz²
¹Pharmacy, CHUV, Lausanne, Switzerland, ²CHUV, Lausanne, Switzerland, ³USB, Basel, Switzerland, ⁴HUG, Geneva, Switzerland, ⁵USZ, Zurich, Switzerland, ⁶Inselspital, Bern, Switzerland, ⁷KSSG, St. Gallen, Switzerland
*Purpose: Multimodal therapeutic strategies used to treat acute antibody-mediated rejection (AMR) could enhance the risk of infection. However, data in this context are scarce.*Methods: We…
2019 American Transplant Congress
What Are Factors That Can Influence The High Immunological Graft Loss Rate In Young Pancreas Transplant Recipients
A. C. Gruessner, J. Renz, S. Saggi, R. W. Gruessner
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Pancreas transplants (tx) are increasingly performed in older patients with type 1 diabetes mellitus. This trend may be explained by the significantly higher immunologic…
2019 American Transplant Congress
Hope in Action: A Multicenter Prospective Study of HIV to HIV Kidney Transplantation
C. Durand¹, S. Huprikar², M. Bowring³, D. Brown¹, B. Haydel⁴, N. Desai³, F. Naqvi¹, R. Friedman-Moraco⁵, N. Turgeon⁶, V. Stosor⁷, J. Charette⁷, S. Mehta⁸, J. Husson⁹, A. Gilbert¹⁰, M. Cooper¹¹, C. Butkus-Small¹², G. Gupta¹³, S. Mehta¹⁴, O. Adebiyi¹⁵, P. Chin-Hong¹⁶, P. Stock¹⁷, A. Massie³, S. Florman⁴, D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Medicine, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, Mount Sinai, New York, NY, ⁵Medicine, Emory University, Atlanta, GA, ⁶Surgery, Emory University, Atlanta, GA, ⁷Medicine, Northwestern University, Chicago, IL, ⁸Medicine, University of Alabama, Birmingham, AL, ⁹Medicine, University of Maryland, Baltimore, MD, ¹⁰Medicine, Georgetown University, Washington DC, DC, ¹¹Department of Surgery, Georgetown University, Washington DC, DC, ¹²Medicine, Cornell University, New York, NY, ¹³Medicine, Virginia Commonwealth University, Richmond, VA, ¹⁴Medicine, New York University, New York, NY, ¹⁵Medicine, Indiana University, Indianapolis, IN, ¹⁶Medicine, University of California at San Francisco, San Francisco, CA, ¹⁷Surgery, University of California at San Francisco, San Francisco, CA
*Purpose:HIV+ donor to HIV+ recipient (HIV D+/R+) kidney transplantation (KT) has had success in South Africa. Expansion of this practice in the US setting of…