Articles tagged "Rejection"

2019 American Transplant Congress
Inhibition of Autophagy Prolongs Recipients Survival through Accelerating CD8⁺T Cell Apoptosis in a Rat Liver Transplantation Model
X. Chen¹, Q. Yang¹, X. Li², Y. Deng¹, G. Chen¹, G. Wang¹
¹Department of Hepatic Surgery, Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: In liver transplantation (LT), acute rejection (AR) remains a common complication that significantly shortens recipient survival although various immunosuppressors have been used in clinical…
2019 American Transplant Congress
Urinary Exosomal microRNA as a Non-Invasive Biomarker for the Diagnosis of Acute Rejection in Kidney Transplant Recipients
J. Seo¹, Y. Lee¹, S. Jung¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Nephrology, Kyung Hee University College of Medicine, Seoul, Korea, Republic of, ²Nephrology, Kyungpook National University College of Medicine, Daegu, Korea, Republic of, ³Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ⁴Nephrology, The St. Mary’s Hospital of Catholic University of Korea, Seoul, Korea, Republic of, ⁵Nephrology, Inje University College of Medicine, Busan, Korea, Republic of
*Purpose: Acute rejection (AR) is the main obstacle to the graft survival after kidney transplantation. Urinary exosome is a promising source of biomarker for various…
2019 American Transplant Congress
Validation of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) of HLA-Sensitized Patients
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: "Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Previously, we…
2019 American Transplant Congress
Belatacept Use in High Kidney Donor Profile Index Kidney Transplant Recipients
D. Britt¹, A. Gharabagi¹, K. Botkin¹, T. Horwedel², C. Carthon¹, J. Hagopian¹
¹Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, ²Veloxis Pharmaceuticals, Cary, NC
*Purpose: To determine whether the use of belatacept is associated with renal function preservation in kidney transplant recipients from donors with a kidney donor profile…
2019 American Transplant Congress
Multi-Center Validation of TruGraf V2 – A Peripheral Blood Diagnostic for Subclincal Kidney Rejection
C. Marsh¹, S. Kurian¹, C. Schieve², R. Heilman³, M. Stegall⁴, S. Rose², J. Case¹, J. Friedewald⁵, M. Abecassis⁵, R. First²
¹Scripps Health, La Jolla, CA, ²Transplant Genomics Inc., Mansfield, MA, ³Mayo Clinic, Scottsdale, AZ, ⁴Mayo Clinic, Rochester, MN, ⁵Northwestern University, Chicago, IL
*Purpose: Unsuspected subclinical acute rejection (subAR) is currently only detectable in 15-25% of invasive surveillance biopsies (SB) and can lead to chronic rejection and poor…
2019 American Transplant Congress
Basiliximab vs. Low-Dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients: Prospective Randomized Study in Southeastern Mexico
G. Martinez-Mier, P. I. Moreno-Ley, L. F. Budar-Fernandez, M. T. Mendez-Lopez, D. A. Barrera-Amoros, M. De la Paz-Roman, L. A. Jimenez-López, E. G. Aguilar-Sandoval, C. A. Allende-Castellanos
Organ Transplantation & Research, IMSS UMAE HE 14, Veracruz, Mexico
*Purpose: Demonstrate that low dose Thymoglobulin (3 mg/kg total ) has similar efficacy (DGF, SGF, BPAR, hospitalizations, adverse events, graft loss and death) than Basiliximab…
2019 American Transplant Congress
Severe Acute Rejection In Human Leukocyte Antigen Identical Renal Transplants: Reviving Mixed Lymphocyte Culture
P. Rajendran¹, M. Cusick², S. Dhingra³, B. Murthy¹
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, ³Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Human leukocyte antigen-identical renal transplants among siblings account for a minority of all renal transplants, but have excellent long-term outcomes due to very minimal…
2019 American Transplant Congress
Are Protocol Biopsies Necessary for Pediatric Renal Transplant Recipients?
E. Allred, E. Ingulli
Pediatrics, UCSD, San Diego, CA
*Purpose: Renal allograft survival indirectly correlates with acute rejection episodes. Subacute rejection is also associated with decreased graft survival. Protocol biopsies (bxs) have been implemented…
2019 American Transplant Congress
Post-Transplant Anti- A Titer >1:128 in A2-Incompatible Kidney Recipients is Associated with Subclinical Antibody Mediated Rejection
V. Kumar, D. Williams, P. MacLennan, M. Mustian, B. Orandi, L. Williams, J. Locke
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Decreased antigen expression among blood group A, subtype 2 (A2), donor kidneys allows these kidneys to be considered as universal donor kidneys and under…
2019 American Transplant Congress
Immunologic Outcomes In Recipients Of Orthotopic Liver Transplant Induced Only With Steroids
S. N. Merwat, A. T. Chatila, M. Bilal, R. Kulkarni, H. L. Stevenson, J. H. Fair, S. K. Merwat, T. Kozlowski, M. A. Mujtaba
The University of Texas Medical Branch, Galveston, TX
*Purpose: Liver allografts are resistant to antibody mediated rejection (AMR) in the presence of preformed alloantibodies. In most cases donor specific antibodies (DSAs) disappear a…