Articles tagged "Rejection"

2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
2019 American Transplant Congress
Effect of Human Leukocytic Antigen Matching on Clinical Outcomes after Deceased Donor Renal Allograft Transplant: A Single Centre Experience
M. E. Gramlick¹, M. K. Heer², S. Yausis², P. R. Trevillian²
¹Department of Surgery, John Hunter Hospital, Newcastle, Australia, ²Newcastle Transplant Unit, John Hunter Hospital, Newcastle, Australia
*Purpose: Human leucocyte antigen (HLA) matching has been the cornerstone of kidney allocation policies. With increasing expertise in assessing and managing immunological risks, the impact…
2019 American Transplant Congress
Fractalkine is Crucial in Ischemia Reperfusion Injury Related to Acute Rejection in an Allogeneic Heart Transplantation Model
T. Kanzawa¹, D. Tokita¹, T. Yamakawa¹, H. Ishigooka¹, H. Fukuda¹, H. Katsumata¹, S. Miyairi¹, R. Ishii¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, T. Imai², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²KAN Research Institute, Kobe, Japan
*Purpose: Ischemia reperfusion injury (IRI) facilitates allograft rejection in renal transplantation recipients (IRI-related rejection). Controlling IRI improves graft survival. Fractalkine (FKN) is an inflammatory chemokine.…
2019 American Transplant Congress
Infectious Risk of Rejection Therapy Following Heart Transplantation; Can It Be Avoided?
M. Kittleson, J. Patel, S. Dimbil, R. J. Levine, G. Esmailian, A. Shen, T. Hage, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The diagnosis of rejection after heart transplantation (HTx) is usually based on the surveillance endomyocardial biopsies (EMB). These protocol biopsies are performed at scheduled…
2019 American Transplant Congress
The Potential Role of IL-33/ST2 Pathway in Renal Allograft Rejection
M. Yu¹, Y. Kim², J. Moon², S. Lee², H. Lee², D. Kim², C. Lee³, Y. Kim², S. Yang²
¹Hanyang University Guri Hospital, Guri, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³Cheju Halla General Hospital, Jeju, Korea, Republic of
*Purpose: Interleukin (IL)-33 is one of IL-1 family cytokine that has pleiotropic effects, such as inflammation promotion and immune response regulation. Recent studies showed that…
2019 American Transplant Congress
Continuous 24-Hour vs. Daily Antithymocyte Globulin (ATG) Infusions for Treatment of Renal Allograft Rejection: Preliminary Results of a Prospective Trial
S. J. Patel, S. Kuten, R. Knight, J. Nolte-Fong, D. Nguyen, E. Graviss, A. Gaber
Methodist Hospital, Houston, TX
*Purpose: When used for acute rejection (AR), ATG is generally administered in the inpatient setting, given the need for intravenous (IV) access, risk of infusion-related…
2019 American Transplant Congress
Impact Of Inhaled Vasodilator Therapy On Early Morbidity And Mortality After Lung Transplant
M. Tomeczkowicz¹, A. Wexler¹, M. Patel², J. Fernandez-Castillo², J. Rusniak¹, E. Mancl³, S. Quddus²
¹Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ²Division of Pulmonary and Critical Care, Loyola University Medical Center, Maywood, IL, ³Loyola University Medical Center, Maywood, IL
*Purpose: Within the first 72 hours of lung transplant, recipients may develop primary graft dysfunction (PGD). This complication is associated with acute and chronic rejection,…
2019 American Transplant Congress
Adjunctive Therapy With Tocilizumab For Treatment Of Acute Antibody Mediated Rejection – 2 Year Experience
K. Venkatachalam, R. Delos Santos, B. Heady, A. Malone, T. Alhamad
Washington University, St. Louis, MO
*Purpose: Reporting our center's experience in use of tocilizumab for treatment of antibody mediated rejection*Methods: We have previously reported the efficacy of Tocilizumab (TCZ), an…
2019 American Transplant Congress
Biomarkers in Multivisceral and Intestinal Transplantation
D. A. Cheung¹, J. Garcia¹, T. Beduschi², A. H. Langshaw¹, K. L. Arheart³, I. A. Gonzalez⁴
¹Pediatric Gastroenterology, University of Miami, Miami, FL, ²Surgery, Division of Liver/GI Transplant, University of Miami, Miami, FL, ³Public Health Sciences, Division of Biostatistics, University of Miami, Miami, FL, ⁴Pediatric Infectious Diseases and Immunology, University of Miami, Miami, FL
*Purpose: Multivisceral transplant (MVT) and isolated intestinal transplant (ITx) are complex surgical procedures that result in a pro-inflammatory state, making interpretation of biomarkers in the…
2019 American Transplant Congress
IgG4 Subclass Class 2 Donor Specific Antibody (DSA) is Associated with Subclinical Rejection in Stable Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests
A. Jackson¹, S. Kanaparthi², B. Burrell³, D. Lucas⁴, R. Vega⁴, A. J. Demetris⁵, S. Feng⁶
¹Surgery, Duke University, Durham, NC, ²The Immune Tolerance Network, Bethesda, MD, ³Immune Tolerance Network, Bethesda, MD, ⁴Medicine, Johns Hopkins University, Baltimore, MD, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA, ⁶Surgery, University of California San Francisco, San Francisco, CA
*Purpose: DSA is a known biomarker of allograft rejection, yet injury phenotype and potential differ across organs. Among pediatric LT recipients entering iWITH (NCT01638559), an…